Zobrazeno 1 - 10
of 145
pro vyhledávání: '"B, Rifkind"'
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0243842 (2020)
Activation of the aryl hydrocarbon receptor (AHR) by the environmental toxin dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin, TCDD) causes diverse toxicities, including thymus atrophy and hepatosteatosis. The mechanisms by which AHR activation by TCDD le
Externí odkaz:
https://doaj.org/article/899b85bebfd94986b88704743d17887b
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin, TCDD) is a carcinogenic and highly toxic industrial byproduct that persists in the environment and produces a pleiotropic toxicity syndrome across vertebrate species that includes wasting, hepatos
Externí odkaz:
https://doaj.org/article/2ec744b98cec42aba26d391463ce2a99
Publikováno v:
The Journal of Biological Chemistry
The aryl hydrocarbon receptor (AHR) is a transcription factor activated by exogenous halogenated polycyclic aromatic hydrocarbon compounds, including the environmental toxin TCDD, 2,3,7,8-tetrachlorodibenzo-p-dioxin, and naturally occurring dietary a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73e2b5476cf6c1e1f9ee2bcbc8cd8049
https://pubmed.ncbi.nlm.nih.gov/34146543
https://pubmed.ncbi.nlm.nih.gov/34146543
Synthesis and Characterization of Polybromo- and Polybromochloro-Dibenzo-p-Dioxins and Dibenzofurans
Autor:
B. Ramalingam, T. Mazer, D. J. Wagel, C. M. Malloy, M. L. Taylor, T. O. Tiernan, J. H. Garrett, Arleen B. Rifkind
Publikováno v:
Chlorinated Dioxins and Dibenzofurans in Perspective ISBN: 9781351070645
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9d208d13ad216b921f2b69afac2fe0a
https://doi.org/10.1201/9781351070645-32
https://doi.org/10.1201/9781351070645-32
Publikováno v:
Drug Metabolism and Disposition. 42:294-300
The environmental toxin and carcinogen 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin) binds and activates the transcription factor aryl hydrocarbon receptor (AHR), inducing CYP1 family cytochrome P450 enzymes. CYP1A2 and its avian ortholog CYP1A5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da7dac34a5c1f28a3c7a99df5ae12b87
https://doi.org/10.1124/dmd.113.055368
https://doi.org/10.1124/dmd.113.055368
Publikováno v:
Journal of Biological Chemistry. 288:21514-21525
Effects of the environmental toxin and carcinogen 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin) include a wasting syndrome associated with decreased gluconeogenesis. TCDD is a potent activator of the aryl hydrocarbon receptor (AHR), a ligand act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44251d1c58468b146bc4da2fb90aa3a1
https://doi.org/10.1074/jbc.m113.458067
https://doi.org/10.1074/jbc.m113.458067
Publikováno v:
Archives of Biochemistry and Biophysics. 468:70-81
Several P450 enzymes localized in the endoplasmic reticulum and thought to be involved primarily in xenobiotic metabolism, including mouse and rat CYP1A1 and mouse CYP1A2, have also been found to translocate to mitochondria. We report here that the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94833bbb611be35abd3fba630e8e33e8
https://doi.org/10.1016/j.abb.2007.08.012
https://doi.org/10.1016/j.abb.2007.08.012
Autor:
Linda Wong, Erin Labitzke, Alexander J Garvin, Arleen B. Rifkind, Richard L. Brown, Silvia Diani-Moore
Publikováno v:
Toxicological Sciences. 90:96-110
Photooxidized tryptophan (TRP) in tissue culture medium elicits a transient cytochrome P450 (CYP1) induction response in cultured cells. We show here that exposure of TRP to window sunlight (aTRP) greatly increased the potency, efficacy, and duration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3297b5cefa43fe1d076ff24bb248e88c
https://doi.org/10.1093/toxsci/kfj065
https://doi.org/10.1093/toxsci/kfj065
Autor:
Arleen B. Rifkind, Terence L. Kirley, Michelle Tickner, Aaron J. Marcus, Silvia Diani-Moore, Joan H.F. Drosopoulos, Emily Wood, Naziba Islam, M. Johan Broekman, Joshua I Park
Publikováno v:
Archives of Biochemistry and Biophysics. 407:49-62
We report here that induction of ectoATPase by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is cell-type specific and not a generalized response to aryl hydrocarbon (Ah) receptor activation. TCDD increased [14C]-ATP and -ADP metabolism in two mouse hep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::380f4fe691b1002b1aabc75c839c0868
https://doi.org/10.1016/s0003-9861(02)00465-4
https://doi.org/10.1016/s0003-9861(02)00465-4
Publikováno v:
Toxicology and Applied Pharmacology. 153:1-11
Arachidonic acid is biotransformed to metabolites active in signal transduction by cytochrome P450 (CYP) as well as by cyclooxygenase and lipoxygenase enzymes. Inducers of CYP1 enzymes, including 2,3,7,8-tetrachlorodibenzo-p-dioxin and other Ah recep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fddd920a32f522c782411518e941329
https://doi.org/10.1006/taap.1998.8468
https://doi.org/10.1006/taap.1998.8468