Zobrazeno 1 - 10
of 1 393
pro vyhledávání: '"B, Pollard"'
Autor:
Hung Caohuy, Ofer Eidelman, Tinghua Chen, Ognoon Mungunsukh, Qingfeng Yang, Nathan I. Walton, Bette S. Pollard, Sara Khanal, Shannon Hentschel, Catalina Florez, Andrew S. Herbert, Harvey B. Pollard
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract SARS-CoV-2-contributes to sickness and death in COVID-19 patients partly by inducing a hyper-proinflammatory immune response in the host airway. This hyper-proinflammatory state involves activation of signaling by NFκB, and unexpectedly, EN
Externí odkaz:
https://doaj.org/article/7a2225a402c0400ca2a99fa970f2b2ac
Publikováno v:
Drugs - Real World Outcomes, Vol 10, Iss 2, Pp 299-307 (2023)
Abstract Background Cardiac glycosides such as digoxin, digitoxin and ouabain are still used around the world to treat patients with chronic heart failure with reduced ejection fraction (HFrEF) and/or atrial fibrillation (AF). However, in the US, onl
Externí odkaz:
https://doaj.org/article/b1d7fd28f0714e008f661f76a4a48030
Autor:
Indu Kohaar, Xijun Zhang, Shyh-Han Tan, Darryl Nousome, Kevin Babcock, Lakshmi Ravindranath, Gauthaman Sukumar, Elisa Mcgrath-Martinez, John Rosenberger, Camille Alba, Amina Ali, Denise Young, Yongmei Chen, Jennifer Cullen, Inger L. Rosner, Isabell A. Sesterhenn, Albert Dobi, Gregory Chesnut, Clesson Turner, Clifton Dalgard, Matthew D. Wilkerson, Harvey B. Pollard, Shiv Srivastava, Gyorgy Petrovics
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
DNA damage repair genes have been linked with increased aggressiveness of prostate cancer, however, the extent of mutation of these genes has not been analyzed within a cohort of African American patients. Here, the authors identify increased mutatio
Externí odkaz:
https://doaj.org/article/1a4c1db7c0244799998d7fa60f644d6a
Autor:
Hung Caohuy, Ofer Eidelman, Tinghua Chen, Shufeng Liu, Qingfeng Yang, Alakesh Bera, Nathan I. Walton, Tony T. Wang, Harvey B. Pollard
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract To initiate SARS-CoV-2 infection, the Receptor Binding Domain (RBD) on the viral spike protein must first bind to the host receptor ACE2 protein on pulmonary and other ACE2-expressing cells. We hypothesized that cardiac glycoside drugs might
Externí odkaz:
https://doaj.org/article/2ea2813bebb54bb3b57a27ab3d2f0753
Publikováno v:
BMC Bioinformatics, Vol 21, Iss 1, Pp 1-8 (2020)
Abstract Background Analysis of somatic mutations from tumor whole exomes has fueled discovery of novel cancer driver genes. However, ~ 98% of the genome is non-coding and includes regulatory elements whose normal cellular functions can be disrupted
Externí odkaz:
https://doaj.org/article/dd9dc439a95449e18165dbc54dc7b8af
Autor:
Q. Yang, A. R. Soltis, G. Sukumar, X. Zhang, H. Caohuy, J. Freedy, C. L. Dalgard, M. D. Wilkerson, H. B. Pollard, B. S. Pollard
Publikováno v:
Respiratory Research, Vol 20, Iss 1, Pp 1-15 (2019)
Abstract Background Several small molecule corrector and potentiator drugs have recently been licensed for Cystic Fibrosis (CF) therapy. However, other aspects of the disease, especially inflammation, are less effectively treated by these drugs. We h
Externí odkaz:
https://doaj.org/article/cfcc43294e7e4d3ca0a63e45c657e5a8
Autor:
Nathan I. Walton, Xijun Zhang, Anthony R. Soltis, Joshua Starr, Clifton L. Dalgard, Matthew D. Wilkerson, Douglas Conrad, Harvey B. Pollard
Publikováno v:
Physiological Reports, Vol 9, Iss 11, Pp n/a-n/a (2021)
Abstract Cystic fibrosis (CF) is a life‐limiting autosomal recessive genetic disease caused by variants in the CFTR gene, most commonly by the [F508del] variant. Although CF is a classical Mendelian disease, genetic variants in several modifier gen
Externí odkaz:
https://doaj.org/article/7bad757c514f45c1b96f79c5d85631a5
Autor:
Bette S. Pollard, Mark. A. Suckow, William R. Wolter, Joshua M. Starr, Ofer Eidelman, Clifton L. Dalgard, Parameet Kumar, Sharmistha Battacharyya, Meera Srivastava, Roopa Biswas, Matthew D. Wilkerson, Xijun Zhang, Qingfeng Yang, Harvey B. Pollard
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Castration Resistant Prostate Cancer (CRPC) is thought to be driven by a collaborative mechanism between TNFα/NFκB and TGFβ signaling, leading to inflammation, Epithelial-to-Mesenchymal-Transition (EMT), and metastasis. Initially, TGFβ is a tumor
Externí odkaz:
https://doaj.org/article/835f8a6f1f46486a86a13beb23b54efd
Autor:
Steven L. Bistricky, Alicia K. Lopez, Tarryn B. Pollard, Alana Egan, Malena Gimenez-Zapiola, Bailey Pascuzzi, Kenia M. Velasquez, Miana Graves
Bedtime procrastination is increasingly recognized as a widespread impediment to health-promoting sleep. Based on its potential malleability, bedtime procrastination is starting to be targeted for intervention using traditional health behavior models
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8b02f7b8c6b713ffc156ac9120ede3d
https://doi.org/10.1101/2023.04.16.23288655
https://doi.org/10.1101/2023.04.16.23288655
Autor:
Hua Wang, Liudmila Cebotaru, Ha Won Lee, QingFeng Yang, Bette S. Pollard, Harvey B. Pollard, William B. Guggino
Publikováno v:
Cellular Physiology and Biochemistry, Vol 40, Iss 5, Pp 1063-1078 (2016)
Background/Aims: Chronic lung infection in cystic fibrosis leads to an inflammatory response that persists because of the chronic presence of bacteria and ultimately leads to a catastrophic failure of lung function. Methods: We use a combination of b
Externí odkaz:
https://doaj.org/article/836c9d236ae2477199b1eaaa4be9ddd3