Zobrazeno 1 - 10
of 130
pro vyhledávání: '"B, Nicol"'
Autor:
Phillip B. Nicol, Danielle Paulson, Gege Qian, X. Shirley Liu, Rafael Irizarry, Avinash D. Sahu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Single-cell transcriptomics has emerged as a powerful tool for understanding how different cells contribute to disease progression by identifying cell types that change across diseases or conditions. However, detecting changing cell types is
Externí odkaz:
https://doaj.org/article/4f488a03a7a34c2f888328d58652862e
Publikováno v:
Computational and Systems Oncology, Vol 2, Iss 2, Pp n/a-n/a (2022)
Abstract Cancer progression, including the development of intratumor heterogeneity, is inherently a spatial process. Mathematical models of tumor evolution may be a useful starting point for understanding the patterns of heterogeneity that can emerge
Externí odkaz:
https://doaj.org/article/6c04e63d72024b098135dfd6c720358f
Autor:
Xiaojing Yang, Jina Nanayakkara, Duncan Claypool, Sadegh Saghafinia, Justin J. M. Wong, Minqi Xu, Xiantao Wang, Christopher J. B. Nicol, Iacovos P. Michael, Markus Hafner, Xiaolong Yang, Neil Renwick
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Lung carcinoids are variably aggressive and mechanistically understudied neuroendocrine neoplasms (NENs). Here, we identified and elucidated the function of a miR-375/yes-associated protein (YAP) axis in lung carcinoid (H727) cells. miR-375
Externí odkaz:
https://doaj.org/article/72661e3a38244d87bdf71ce5806af456
Autor:
Martin Kaufmann, Natasha Iaboni, Amoon Jamzad, David Hurlbut, Kevin Yi Mi Ren, John F. Rudan, Parvin Mousavi, Gabor Fichtinger, Sonal Varma, Antonio Caycedo-Marulanda, Christopher J. B. Nicol
Publikováno v:
Metabolites, Vol 13, Iss 4, p 508 (2023)
Colorectal cancer (CRC) is the second leading cause of cancer deaths. Despite recent advances, five-year survival rates remain largely unchanged. Desorption electrospray ionization mass spectrometry imaging (DESI) is an emerging nondestructive metabo
Externí odkaz:
https://doaj.org/article/4282cf5ad5d44339910afe1cc2170a76
Autor:
Phillip B. Nicol, Kevin R. Coombes, Courtney Deaver, Oksana Chkrebtii, Subhadeep Paul, Amanda E. Toland, Amir Asiaee
Publikováno v:
Computational and Systems Oncology, Vol 1, Iss 2, Pp n/a-n/a (2021)
Abstract Motivation: Cancer is the process of accumulating genetic alterations that confer selective advantages to tumor cells. The order in which aberrations occur is not arbitrary, and inferring the order of events is challenging due to the lack of
Externí odkaz:
https://doaj.org/article/d17ed45d441d4d6083e19ea0d651957c
Autor:
T. Azad, H. J. Janse van Rensburg, E. D. Lightbody, B. Neveu, A. Champagne, A. Ghaffari, V. R. Kay, Y. Hao, H. Shen, B. Yeung, B. A. Croy, K. L. Guan, F. Pouliot, J. Zhang, C. J. B. Nicol, X. Yang
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
The Hippo pathway is a major orchestrator of organ development and homeostasis. Here Azad and colleagues develop a biosensor to monitor the activity of the Hippo pathway component LATS and identify VEGF signalling as an upstream regulator of LATS, su
Externí odkaz:
https://doaj.org/article/85b8748f8e55400f94efb6cc36e66651
Autor:
Phillip B. Nicol, Danielle Paulson, Gege Qian, X. Shirley Liu, Rafael Irizarry, Avinash D. Sahu
Single-cell transcriptomics has emerged as a powerful tool for understanding how different cells contribute to disease progression by identifying cell types that change across diseases or conditions. However, detecting changing cell types is challeng
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9c07a3c2fecf92e30896c607e8fa796
https://doi.org/10.1101/2023.05.06.539326
https://doi.org/10.1101/2023.05.06.539326
Autor:
Phillip B. Nicol, Jeffrey W. Miller
Dimensionality reduction is a critical step in the analysis of single-cell RNA-seq data. The standard approach is to apply a transformation to the count matrix, followed by principal components analysis. However, this approach can spuriously indicate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd6849978acfa2d9e5d0007f5174c09d
https://doi.org/10.1101/2023.04.21.537881
https://doi.org/10.1101/2023.04.21.537881
Autor:
Ming-Chang Chiang, Christopher J. B. Nicol, Shy-Shyong Lo, Shiang-Wei Hung, Chieh-Ju Wang, Chien-Hung Lin
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 19; Pages: 11678
Oxygen glucose deprivation (OGD) can produce hypoxia-induced neurotoxicity and is a mature in vitro model of hypoxic cell damage. Activated AMP-activated protein kinase (AMPK) regulates a downstream pathway that substantially increases bioenergy prod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cbe53ad36cb41bfe2d624e370fa265b
https://pubmed.ncbi.nlm.nih.gov/36232980
https://pubmed.ncbi.nlm.nih.gov/36232980
Publikováno v:
Comput Syst Oncol
MotivationCancer progression, including the development of intratumor heterogeneity, is inherently a spatial process. Mathematical models of tumor evolution can provide insights into patterns of heterogeneity that can emerge in the presence of spatia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8fddfa033035050a0ec32e4fe8f8b41
https://doi.org/10.1002/cso2.1033
https://doi.org/10.1002/cso2.1033