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Akademický článek
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Publikováno v:
Journal of Aging Research and Lifestyle. :1-4
Background: Midlife cigarette smoking is associated with increased risk for both midlife neuropsychiatric symptoms and development of dementia later in life. Objective: This study was designed to extend knowledge of these relationships by assessing f
Autor:
A Wright, Marie-José Blouin, C N Ou, M Sorette, Hugues Beauchemin, M.E. De Paepe, B Nakamoto, A M Bleau, George Stamatoyannopoulos, Marie Trudel
Publikováno v:
Nature Medicine. 6:177-182
Sickle cell disease is a hereditary disorder characterized by erythrocyte deformity due to hemoglobin polymerization. We assessed in vivo the potential curative threshold of fetal hemoglobin in the SAD transgenic mouse model of sickle cell disease us
Autor:
Cm, Shikuma, M, Gerschenson, J, Ananworanich, Vg, Valcour, N, Teeratakulpisarn, T, Jadwattanakul, V, Degruttola, C-Y, Liang, Jc, McArthur, Gj, Ebenezer, N, Chomchey, P, Praihirunkit, P, Hongchookiath, P, Mathajittiphun, B, Nakamoto, P, Hauer, P, Phanuphak, N, Phanuphak
Publikováno v:
HIV medicine. 13(10)
Distal leg epidermal nerve fibre density (ENFD) is a validated predictor of small unmyelinated nerve fibre damage and neuropathy risk in HIV infection. As pre-existing damage may increase the risk of neuropathy following antiretroviral (ARV) therapy,
Autor:
J L, Abkowitz, K M, Sabo, B, Nakamoto, C A, Blau, F H, Martin, K M, Zsebo, T, Papayannopoulou
Publikováno v:
Blood. 78:2198-2202
To provide insights into the pathogenesis of Diamond-Blackfan anemia, we examined the in vitro response of erythroid progenitors to the recently isolated ligand for c-kit (stem cell factor, SCF). For these studies, marrow or blood mononuclear cells f
Publikováno v:
Blood. 95(4)
A substantial body of published data suggests activation of lineage-specific genes in multipotential hemopoietic cells before their unilineage commitment. Because the behavior and plasticity of cells isolated in vitro away from microenvironmental con
Publikováno v:
Blood. 90(12)
Although the use of cytokine-mobilized peripheral blood stem cells has gained a significant momentum in clinical transplantation, the mobilization schemes practiced are guided by a great deal of empiricism. The mechanism(s) by which cytokines or chem
Publikováno v:
Blood. 90(2)
The Flt3 receptor is expressed in primitive hematopoietic cells and its ligand exerts proliferative effects on these cells in vitro in synergy with other cytokines. To expand on the functional properties of Flt3 ligand (FL) in vivo we treated nonhuma
Autor:
G, Stamatoyannopoulos, C A, Blau, B, Nakamoto, B, Josephson, Q, Li, E, Liakopoulou, B, Pace, T, Papayannopoulou, S W, Brusilow, G, Dover
Publikováno v:
Blood. 84(9)
Butyrate induces fetal hemoglobin (HbF) synthesis in cultures of erythroid progenitors, in primates, and in man. The mechanism by which this compound stimulates gamma-globin synthesis is unknown. In the course of butyrate catabolism, beta oxidation b