Zobrazeno 1 - 10
of 162
pro vyhledávání: '"B, Meeker"'
Autor:
Carli K. Opland, Miles R. Bryan, Braxton Harris, Jake McGillion-Moore, Xu Tian, Youjun Chen, Michelle S. Itano, Graham H. Diering, Rick B. Meeker, Todd J. Cohen
Publikováno v:
iScience, Vol 26, Iss 6, Pp 106905- (2023)
Summary: Tau-mediated toxicity is associated with cognitive decline and Alzheimer’s disease (AD) progression. In particular, tau post-translational modifications (PTMs) are thought to generate aberrant tau species resulting in neuronal dysfunction.
Externí odkaz:
https://doaj.org/article/b7f1210596e04e69bf9b211b6c093c4c
Autor:
I. Y. Quiroga, A. E. Cruikshank, M. L. Bond, K. S. M. Reed, B. A. Evangelista, J. H. Tseng, J. V. Ragusa, R. B. Meeker, H. Won, S. Cohen, T. J. Cohen, D. H. Phanstiel
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-12 (2022)
Abstract Background Alzheimer’s disease (AD) is a progressive neurodegenerative disease that impacts nearly 400 million people worldwide. The accumulation of amyloid beta (Aβ) in the brain has historically been associated with AD, and recent evide
Externí odkaz:
https://doaj.org/article/cb3aed0519f247af857ffadcda0743ec
Autor:
Irina Balan, Laure Aurelian, Kimberly S. Williams, Brian Campbell, Rick B. Meeker, A. Leslie Morrow
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
We recently discovered that (3α,5α)3-hydroxypregnan-20-one (allopregnanolone) inhibits pro-inflammatory toll-like receptor (TLR) activation and cytokine/chemokine production in mouse macrophage RAW264.7 cells. The present studies evaluate neuroster
Externí odkaz:
https://doaj.org/article/44ed84a4e3a84904b61c24de85fc33d0
Autor:
Douglas J. Hermes, Ian R. Jacobs, Megan C. Key, Alexis F. League, Barkha J. Yadav-Samudrala, Changqing Xu, Virginia D. McLane, Sara R. Nass, Wei Jiang, Rick B. Meeker, Bogna M. Ignatowska-Jankowska, Aron H. Lichtman, Zibo Li, Zhanhong Wu, Hong Yuan, Pamela E. Knapp, Kurt F. Hauser, Sylvia Fitting
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-26 (2020)
Abstract Background Human immunodeficiency virus type-1 (HIV-1) and opiates cause long-term inflammatory insult to the central nervous system (CNS) and worsen disease progression and HIV-1-related neuropathology. The combination of these proinflammat
Externí odkaz:
https://doaj.org/article/9e4741df53be4e07958134c87b308da3
Autor:
Amanda M Crooks, Rick B Meeker
Publikováno v:
Neural Regeneration Research, Vol 17, Iss 1, Pp 95-96 (2022)
Externí odkaz:
https://doaj.org/article/eaeea845e72a4005801bf93385b57cf0
Autor:
Thomas Lane, Vadim Makarov, Julie A. E. Nelson, Rick B. Meeker, Giuseppina Sanna, Olga Riabova, Elena Kazakova, Natalia Monakhova, Andrey Tsedilin, Fabio Urbina, Thane Jones, Ashley Suchy, Sean Ekins
Publikováno v:
Journal of Medicinal Chemistry. 66:6193-6217
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2de2716b5fc8243f868b16421806e17d
https://doi.org/10.1021/acs.jmedchem.2c02055
https://doi.org/10.1021/acs.jmedchem.2c02055
Autor:
Connor M. Wander, Jui-Heng Tseng, Sheng Song, Heba A. Al Housseiny, Dalton S. Tart, Aditi Ajit, Yen-Yu Ian Shih, Rebecca Lobrovich, Juan Song, Rick B. Meeker, David J. Irwin, Todd J. Cohen
Publikováno v:
iScience, Vol 23, Iss 7, Pp 101255- (2020)
Summary: The microtubule-associated tau protein forms pathological inclusions that accumulate in an age-dependent manner in tauopathies including Alzheimer's disease (AD). Since age is the major risk factor for AD, we examined endogenous tau species
Externí odkaz:
https://doaj.org/article/4d3bd9a5d99a43c1a2f2a65407b70fe6
Autor:
Jui-Heng Tseng, Ling Xie, Sheng Song, Youmei Xie, Lauren Allen, Deepa Ajit, Jau-Shyong Hong, Xian Chen, Rick B. Meeker, Todd J. Cohen
Publikováno v:
Cell Reports, Vol 20, Iss 9, Pp 2169-2183 (2017)
The initiating events that promote tau mislocalization and pathology in Alzheimer’s disease (AD) are not well defined, partly because of the lack of endogenous models that recapitulate tau dysfunction. We exposed wild-type neurons to a neuroinflamm
Externí odkaz:
https://doaj.org/article/1665a8b11919450b82d0f39837a40b91
Publikováno v:
Journal of Youth Development. 17:1-20
Youth Development programming that engages youth to work side by side with local leaders creates an environment where youth develop civic skills. These skills include a greater understanding of the legislative process, their role in our democracy, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f90cc166daa5e798502f405e53943d2
https://doi.org/10.5195/jyd.2022.1194
https://doi.org/10.5195/jyd.2022.1194
Autor:
Rick B Meeker, Kimberly S Williams
Publikováno v:
Neural Regeneration Research, Vol 10, Iss 5, Pp 721-725 (2015)
The strong repair and pro-survival functions of neurotrophins at their primary receptors, TrkA, TrkB and TrkC, have made them attractive candidates for treatment of nervous system injury and disease. However, difficulties with the clinical implementa
Externí odkaz:
https://doaj.org/article/5dd1f1b1de734fd0bb3a649ab7c7f3ea