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Zonisamide safety in pregnancy: Data from the UK and Ireland epilepsy and pregnancy register

Autor: G McCluskey, B Liggan, WH Smithson, Stephen J. Hunt, B. Irwin, Jim Morrow, Ellen Campbell, Aline Russell, Norman Delanty, L. Parsons, Patrick J. Morrison, John Craig, L MacKillop, Rebecca Bromley, Sinéad M. Murphy, Michael Owen Kinney, C Heath

Publikováno v: Seizure. 91

Background Animal data suggest teratogenic effects with zonisamide use and risk of pregnancy losses. Human data following zonisamide exposure are presently limited, but suggest low risk of malformation with elevated risk of low birth weight. Objectiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::430590f386d332bec96b41a28e9b1be2
https://pubmed.ncbi.nlm.nih.gov/34352561

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Changing antiepilepsy drug-prescribing trends in women with epilepsy in the UK and Ireland and the impact on major congenital malformations

Autor: Ellen Campbell, Aline Russell, Norman Delanty, L. Parsons, Patrick J. Morrison, Michael Owen Kinney, B Liggan, Stephen J. Hunt, B. Irwin, John Craig, James I. Morrow, Henry Smithson, Christopher Patterson, Rebecca Bromley

Publikováno v: Kinney, M O, Morrow, J, Patterson, C C, Campbell, E, Russell, A, Smithson, H W, Parsons, L, Morrison, P J, Bromley, R, Liggan, B, Delanty, N, Irwin, B, Hunt, S J & Craig, J J 2018, ' Changing antiepilepsy drug-prescribing trends in women with epilepsy in the UK and Ireland and the impact on major congenital malformations ', Journal of neurology, neurosurgery, and psychiatry . https://doi.org/10.1136/jnnp-2017-317368
Kinney, M O, Morrow, J, Patterson, C C, Campbell, E, Russell, A, Smithson, H W, Parsons, L, Morrison, P J, Bromley, R, Liggan, B, Delanty, N, Irwin, B, Hunt, S J & Craig, J J 2018, ' Changing antiepilepsy drug-prescribing trends in women with epilepsy in the UK and Ireland and the impact on major congenital malformations ', Journal of Neurology, Neurosurgery & Psychiatry . https://doi.org/10.1136/jnnp-2017-317368

ObjectivesAfter 20 years of data collection, pregnancy registers have informed prescribing practice. Various populations show trends for a reduction in valproate prescribing, which is associated with an increased risk of anatomical teratogenesis and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13d3aebfa3af72b80c0fb87d31936f5c
https://doi.org/10.1136/jnnp-2017-317368

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Akademický článek

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Malformation risks of antiepileptic drug monotherapies in pregnancy: updated results from the UK and Ireland Epilepsy and Pregnancy Registers

Autor: B. Irwin, Jim Morrow, Norman Delanty, John Craig, Ellen Campbell, F Kennedy, Patrick J. Morrison, Aline Russell, B Liggan, W.H. Smithson, Stephen J. Hunt, L. Parsons

Publikováno v: Journal of Neurology, Neurosurgery & Psychiatry. 85:1029-1034

Antiepileptic drug (AED) exposure during pregnancy increases the risk of major congenital malformations (MCMs). The magnitude of this risk varies by AED exposure. Here we provide updated results from the UK Epilepsy and Pregnancy Register of the risk

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21f51b681bbf7f2821752a28de2912ec
https://doi.org/10.1136/jnnp-2013-306318

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Akademický článek

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Levetiracetam in pregnancy: Results from the UK and Ireland epilepsy and pregnancy registers

Autor: Jim Morrow, W.H. Smithson, John Craig, Patrick J. Morrison, Aline Russell, E. Mawhinney, B Liggan, Norman Delanty, L. Parsons, Stephen J. Hunt, B. Irwin

Publikováno v: Neurology. 80:400-405

Objectives: Levetiracetam is a broad-spectrum antiepileptic drug (AED) which is currently licensed in the United States and the United Kingdom and Ireland for use as adjunctive treatment of focal-onset seizures and myoclonic seizures or generalized t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25d9ba1df687b139f4b9a9682e61774a
https://doi.org/10.1212/wnl.0b013e31827f0874

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Vigabatrin retinopathy in an Irish cohort: lack of correlation with dose

Autor: Norman Delanty, Gianpiero L. Cavalleri, Irene Reid, Patricia Logan, Colin P. Doherty, Peter Kinirons, Dierdre O'Rourke, B Liggan

Publikováno v: Epilepsia. 47(2)

Summary: Purpose: The anticonvulsant vigabatrin (VGB) causes irreversible visual-field constriction in 19–92% of patients. It is unclear whether this correlates with dosing, and the natural history of the retinopathy remains obscure. We conducted a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::659bf9a44f7b795b9d75d2474992f5b0
https://pubmed.ncbi.nlm.nih.gov/16499754

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051 Valproate and the risk for congenital malformations; is formulation and dosage regime important?

Autor: E. Mawhinney, I. Robertson, W.H. Smithson, Aline Russell, L. Parsons, Norman Delanty, Patrick J. Morrison, J. Campbell, Stephen J. Hunt, B. Irwin, Jim Morrow, B Liggan, John Craig

Publikováno v: Journal of Neurology, Neurosurgery & Psychiatry. 83:e1.217-e1

Background Use of valproate in pregnancy, especially in doses over 1000mg a day, is known to be associated with a higher risk for major congenital malformations compared with other antiepileptic drugs. We sought to investigate whether the increased r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0a48f967fc76861d6470847a746ee31c
https://doi.org/10.1136/jnnp-2011-301993.93

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