Zobrazeno 1 - 10
of 87
pro vyhledávání: '"B, Le Bourdelles"'
Delineation of the Structural Determinants of the N-Methyl-D-Aspartate Receptor Glycine Binding Site
Publikováno v:
Journal of Neurochemistry. 72:1694-1698
In this study, we have further delineated the domains of the N-methyl-D-aspartate receptor NR1 subunit that contribute to the glycine co-agonist binding site. Taking an iterative approach, we have constructed truncation mutants of the NR1 subunit, tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a8f71819145c97a022f67dde24ea1ee
https://doi.org/10.1046/j.1471-4159.1999.721694.x
https://doi.org/10.1046/j.1471-4159.1999.721694.x
Autor:
Paul J. Whiting, Dalip J. S. Sirinathsinghji, Keith A. Wafford, Robert P. Heavens, Smith David W, Louise Hewson, N. Brown, Michael Rigby, B. Le Bourdelles, Ruth M. McKernan, Timothy P. Bonnert, Sophie J. Farrar
Publikováno v:
Proceedings of the National Academy of Sciences. 96:9891-9896
γ-Aminobutyric acid type A (GABA-A) receptors are a major mediator of inhibitory neurotransmission in the mammalian central nervous system, and the site of action of a number of clinically important drugs. These receptors exist as a family of subtyp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b515042ed73c06d7f3a886c991b16e4
https://doi.org/10.1073/pnas.96.17.9891
https://doi.org/10.1073/pnas.96.17.9891
Autor:
Paul J. Whiting, Smith David W, Dalip J. S. Sirinathsinghji, Raymond G. Hill, S. Kelly, J.H. Xuereb, A. J. Butler, R. Hills, R. Hammans, B. Le Bourdelles, Michael Rigby, Robert P. Heavens
Publikováno v:
Neuroscience. 73:429-447
The expression of the messenger RNAs encoding N-methyl- d-aspartate receptor subunits in neurologically normal post-mortem human brain was studied by in situ hybridization. In the caudate, putamen and nucleus accumbens strong hybridization signals we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a348887ee41f0fcc04f64ffa56e513d
https://doi.org/10.1016/0306-4522(96)00089-9
https://doi.org/10.1016/0306-4522(96)00089-9
Autor:
J. Attwood, Susan Povey, Hugh Gurling, C. G. See, B. Le Bourdelles, Karen Woodward, Paul J. Whiting, Peter Brett, Mary M. Robertson, Gursharan Kalsi
Publikováno v:
Annals of Human Genetics. 58:95-100
A cDNA clone of the NMDAR1 (isoform E) has been used to screen both lambda and cosmid genomic libraries. A genomic phage clone was identified and sequenced and was found to contain some of the 3' coding regions of the GRIN1 gene. This clone was used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::342b127ed1a20c3cf65ecf4d380a5d04
https://doi.org/10.1111/j.1469-1809.1994.tb01879.x
https://doi.org/10.1111/j.1469-1809.1994.tb01879.x
Autor:
B, Le BOURDELLES, L, PAGES
Publikováno v:
La Presse medicale. 54
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::79cf5fe156501fd64ebabe2c2d72177a
https://pubmed.ncbi.nlm.nih.gov/20995328
https://pubmed.ncbi.nlm.nih.gov/20995328
Publikováno v:
Comptes rendus des seances de la Societe de biologie et de ses filiales. 141(5-6)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1185bc9e5f2b7d316302204a3d6ef2d0
https://pubmed.ncbi.nlm.nih.gov/20262550
https://pubmed.ncbi.nlm.nih.gov/20262550
Autor:
K Quirk, C I Ragan, Eric A. Barnard, P C Harkness, Paul J. Whiting, B. Le Bourdelles, Ruth M. McKernan, K. L. Hadingham, A. L. Horne, John A. Kemp
Publikováno v:
Proceedings of the National Academy of Sciences. 89:6378-6382
The differential sensitivity of type A gamma-aminobutyric acid (GABAA) receptors to benzodiazepine ligands seen in the mammalian nervous system is thought to be generated by the existence of a number of different receptor subtypes, assembled from a r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f474aa3ff5906690d76a930a1bb3190e
https://doi.org/10.1073/pnas.89.14.6378
https://doi.org/10.1073/pnas.89.14.6378
Publikováno v:
Journal of neurochemistry. 64(2)
The cDNA NYMDAR1 (NR1) encodes a single polypeptide that forms a receptor-channel complex with electrophsiological and pharmacological properties characteristic of the N-methyl-D-aspartate receptor. Homomeric NR1 recombinant receptors expressed in Xe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1e6a1c8c35e83806d074b63a0c3a55c
https://pubmed.ncbi.nlm.nih.gov/7830044
https://pubmed.ncbi.nlm.nih.gov/7830044
Autor:
Paul J. Whiting, James M. Sikela, C J Bain, John A. Kemp, B. Le Bourdelles, Keith A. Wafford, George R. Marshall, Andrea S. Wilcox
Publikováno v:
Journal of neurochemistry. 62(6)
Using expression cloning, and more recently using polymerase chain reaction cloning approaches, a family of rat N-methyl-D-aspartate (NMDA) receptor subunit cDNAs has been described (NR1, NR2A, NR2B, NR2C, and NR2D). Here we report cloning and sequen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee79e864c066523dcf2ac17751124016
https://pubmed.ncbi.nlm.nih.gov/8189218
https://pubmed.ncbi.nlm.nih.gov/8189218
Publikováno v:
Molecular pharmacology. 43(6)
cDNAs encoding human alpha 2 and alpha 3 gamma-aminobutyric acidA receptor subunits have been cloned. Their deduced amino acid sequences show much sequence identity with the published bovine sequences (98.2% and 97.0% for alpha 2 and alpha 3, respect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c660b2b45fadc052fd8c7adccc8dd82a
https://pubmed.ncbi.nlm.nih.gov/8391122
https://pubmed.ncbi.nlm.nih.gov/8391122