Zobrazeno 1 - 10
of 1 688
pro vyhledávání: '"B, Kopp"'
Autor:
Weiqin Yin, Praveen Kumar Rajvanshi, Heather M. Rogers, Teruhiko Yoshida, Jeffrey B. Kopp, Xiuli An, Max Gassmann, Constance T. Noguchi
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Erythropoietin (EPO) plays a key role in energy metabolism, with EPO receptor (EpoR) expression in white adipose tissue (WAT) mediating its metabolic activity. Here, we show that male mice lacking EpoR in adipose tissue exhibit increased fat
Externí odkaz:
https://doaj.org/article/e97bfac0edc345d1ab726c7a230f401b
Autor:
Samuel P. Border, John E. Tomaszewski, Teruhiko Yoshida, Jeffrey B. Kopp, Jeffrey B. Hodgin, William L. Clapp, Avi Z. Rosenberg, Jill P. Buyon, Pinaki Sarder
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract HistoLens is an open-source graphical user interface developed using MATLAB AppDesigner for visual and quantitative analysis of histological datasets. HistoLens enables users to interrogate sets of digitally annotated whole slide images to e
Externí odkaz:
https://doaj.org/article/d3b33c7071f24ca3a34b44527b736dd1
Publikováno v:
Experimental Biology and Medicine, Vol 249 (2024)
Aldehyde dehydrogenase 1, family member A2, is a retinoic acid-synthesizing enzyme encoded by Aldh1a2 in mice and ALDH1A2 in humans. This enzyme is indispensable for kidney development, but its role in kidney physiology and pathophysiology remains to
Externí odkaz:
https://doaj.org/article/2ceb0cffc8fa43e3ab00cd04e3648d55
Autor:
Teruhiko Yoshida, Khun Zaw Latt, Avi Z Rosenberg, Briana A Santo, Komuraiah Myakala, Yu Ishimoto, Yongmei Zhao, Shashi Shrivastav, Bryce A Jones, Xiaoping Yang, Xiaoxin X Wang, Vincent M Tutino, Pinaki Sarder, Moshe Levi, Koji Okamoto, Cheryl A Winkler, Jeffrey B Kopp
Publikováno v:
eLife, Vol 12 (2024)
HIV disease remains prevalent in the USA and chronic kidney disease remains a major cause of morbidity in HIV-1-positive patients. Host double-stranded RNA (dsRNA)-activated protein kinase (PKR) is a sensor for viral dsRNA, including HIV-1. We show t
Externí odkaz:
https://doaj.org/article/30612ed355a4430f8889c67842e2d30b
Autor:
Yask Gupta, David J. Friedman, Michelle T. McNulty, Atlas Khan, Brandon Lane, Chen Wang, Juntao Ke, Gina Jin, Benjamin Wooden, Andrea L. Knob, Tze Y. Lim, Gerald B. Appel, Kinsie Huggins, Lili Liu, Adele Mitrotti, Megan C. Stangl, Andrew Bomback, Rik Westland, Monica Bodria, Maddalena Marasa, Ning Shang, David J. Cohen, Russell J. Crew, William Morello, Pietro Canetta, Jai Radhakrishnan, Jeremiah Martino, Qingxue Liu, Wendy K. Chung, Angelica Espinoza, Yuan Luo, Wei-Qi Wei, Qiping Feng, Chunhua Weng, Yilu Fang, Iftikhar J. Kullo, Mohammadreza Naderian, Nita Limdi, Marguerite R. Irvin, Hemant Tiwari, Sumit Mohan, Maya Rao, Geoffrey K. Dube, Ninad S. Chaudhary, Orlando M. Gutiérrez, Suzanne E. Judd, Mary Cushman, Leslie A. Lange, Ethan M. Lange, Daniel L. Bivona, Miguel Verbitsky, Cheryl A. Winkler, Jeffrey B. Kopp, Dominick Santoriello, Ibrahim Batal, Sérgio Veloso Brant Pinheiro, Eduardo Araújo Oliveira, Ana Cristina Simoes e Silva, Isabella Pisani, Enrico Fiaccadori, Fangming Lin, Loreto Gesualdo, Antonio Amoroso, Gian Marco Ghiggeri, Vivette D. D’Agati, Riccardo Magistroni, Eimear E. Kenny, Ruth J. F. Loos, Giovanni Montini, Friedhelm Hildebrandt, Dirk S. Paul, Slavé Petrovski, David B. Goldstein, Matthias Kretzler, Rasheed Gbadegesin, Ali G. Gharavi, Krzysztof Kiryluk, Matthew G. Sampson, Martin R. Pollak, Simone Sanna-Cherchi
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-8 (2023)
Abstract African Americans have a significantly higher risk of developing chronic kidney disease, especially focal segmental glomerulosclerosis -, than European Americans. Two coding variants (G1 and G2) in the APOL1 gene play a major role in this di
Externí odkaz:
https://doaj.org/article/9f6233ad88a44f828fd1c0264b712139
Autor:
Colleen S. Curran, Jeffrey B. Kopp
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-19 (2023)
Abstract Early-stage detection of chronic kidney diseases (CKD) is important to treatment that may slow and occasionally halt CKD progression. CKD of diverse etiologies share similar histologic patterns of glomerulosclerosis, tubular atrophy, and int
Externí odkaz:
https://doaj.org/article/0a73bbab43da45aeb47f43cf46d5e408
Autor:
Khamis Mustafa, Ying Han, Dan He, Ying Wang, Nan Niu, Pedro A Jose, Yinong Jiang, Jeffrey B Kopp, Hewang Lee, Peng Qu
Publikováno v:
PLoS ONE, Vol 19, Iss 2, p e0295837 (2024)
Poly-(ADP-ribose) polymerases (PARPs) are a protein family that make ADP-ribose modifications on target genes and proteins. PARP family members contribute to the pathogenesis of chronic inflammatory diseases, including atherosclerosis, in which monoc
Externí odkaz:
https://doaj.org/article/102d8713b87e4c11b5f2ddf9bd817c49
Autor:
Xiumei Hong, Avi Z. Rosenberg, Jurgen Heymann, Teruhiko Yoshida, Sushrut S. Waikar, Titilayo O. Ilori, Guoying Wang, Heather Rebuck, Colleen Pearson, Mei‐Cheng Wang, Cheryl A. Winkler, Jeffrey B. Kopp, Xiaobin Wang
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 22 (2023)
Background Pregnancy complications are risk factors for cardiovascular disease (CVD). Little is known about the role of renal biomarkers measured shortly after delivery, individually or in combination with pregnancy complications, in predicting subse
Externí odkaz:
https://doaj.org/article/0cd0fab5acf542fdadd9fb0d8b5990be
Autor:
Junjun Luan, Jingqi Fu, Congcong Jiao, Xiangnan Hao, Zixuan Feng, Lingzi Zhu, Yixiao Zhang, Guangyu Zhou, Hongyu Li, Wei Yang, Peter S. T. Yuen, Jeffrey B. Kopp, Jingbo Pi, Hua Zhou
Publikováno v:
Cell Death and Disease, Vol 13, Iss 11, Pp 1-13 (2022)
Abstract Inflammation is an important factor in the progression from acute kidney injury (AKI) to chronic kidney disease (CKD). The role of interleukin (IL)-18 in this progression has not been examined. We aimed to clarify whether and how IL-18 limit
Externí odkaz:
https://doaj.org/article/0c552b078d2848538d17d130c2ef86bc
Autor:
Brendon Lutnick, David Manthey, Jan U. Becker, Brandon Ginley, Katharina Moos, Jonathan E. Zuckerman, Luis Rodrigues, Alexander J. Gallan, Laura Barisoni, Charles E. Alpers, Xiaoxin X. Wang, Komuraiah Myakala, Bryce A. Jones, Moshe Levi, Jeffrey B. Kopp, Teruhiko Yoshida, Jarcy Zee, Seung Seok Han, Sanjay Jain, Avi Z. Rosenberg, Kuang Yu. Jen, Pinaki Sarder, the Kidney Precision Medicine Project
Publikováno v:
Communications Medicine, Vol 2, Iss 1, Pp 1-15 (2022)
Lutnick et al. develop a cloud-based deep learning tool for whole slide image segmentation. The authors provide several examples of its application in renal pathology, for segmenting glomeruli, interstitial fibrosis and other features of interest.
Externí odkaz:
https://doaj.org/article/55a83f05e2a54ed1a808a7fafb19b7b9