Zobrazeno 1 - 10
of 147
pro vyhledávání: '"B, Kiosses"'
Autor:
Juan Yu, Elsa Meneses-Salas, Jennifer L. Johnson, Susanna Manenti, Mouad Ait Kbaich, Danni Chen, Kasra Askari, Jing He, Aparna Shukla, Binchu Shaji, Rosana Gonzalez-Quintial, Ben A. Croker, Jinzhong Zhang, Hal Hoffman, William B. Kiosses, Catherine Hedrick, Kersi Pestonjamasp, Nathan Wineinger, Roberto Baccala, Sergio D. Catz
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114598- (2024)
Summary: Endosomal Toll-like receptors (eTLRs) are essential for the sensing of non-self through RNA and DNA detection. Here, using spatiotemporal analysis of vesicular dynamics, super-resolution microscopy studies, and functional assays, we show tha
Externí odkaz:
https://doaj.org/article/45ad18936d5d4d02bc4122545d0ebb95
Autor:
Melissa A. Meyer, Huy Q. Dinh, Ahmad Alimadadi, Daniel J. Araujo, Nandini Chatterjee, Norma A. Gutierrez, Yanfang Peipei Zhu, Emma L. Hunter, Shu Liang, Gregory Seumois, William B. Kiosses, Sergio D. Catz, Pandurangan Vijayanand, Christian Ottensmeier, Catherine C. Hedrick
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
PurposeDue to their abundance in the blood, low RNA content, and short lifespan, neutrophils have been classically considered to be one homogenous pool. However, recent work has found that mature neutrophils and neutrophil progenitors are composed of
Externí odkaz:
https://doaj.org/article/bf6b900ace434ede9efa62d8dbe73cc9
Autor:
Jennifer L. Johnson, Elsa Meneses-Salas, Mahalakshmi Ramadass, Jlenia Monfregola, Farhana Rahman, Raquel Carvalho Gontijo, William B. Kiosses, Kersi Pestonjamasp, Dale Allen, Jinzhong Zhang, Douglas G. Osborne, Yanfang Peipei Zhu, Nathan Wineinger, Kasra Askari, Danni Chen, Juan Yu, Scott C. Henderson, Catherine C. Hedrick, Matilde Valeria Ursini, Sergio Grinstein, Daniel D. Billadeau, Sergio D. Catz
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-24 (2022)
Responsive exocytosis in neutrophil leukocytes involves actin depolymerisation-dependent sequential release of gelatinase granules, then strongly pro-inflammatory azurophilic granules. Here authors show that the actin nucleator protein WASH facilitat
Externí odkaz:
https://doaj.org/article/9638c498eebb49f28ed25260528bc5a9
Autor:
Lindsey E. Padgett, Paola M. Marcovecchio, Claire E. Olingy, Daniel J. Araujo, Kathleen Steel, Huy Q. Dinh, Ahmad Alimadadi, Yanfang Peipei Zhu, Melissa A. Meyer, William B. Kiosses, Graham D. Thomas, Catherine C. Hedrick
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
CD8+ T cells drive anti-cancer immunity in response to antigen-presenting cells such as dendritic cells and subpopulations of monocytes and macrophages. While CD14+ classical monocytes modulate CD8+ T cell responses, the contributions of CD16+ noncla
Externí odkaz:
https://doaj.org/article/c4df218d6f674ff49fed2a766ea2cf59
Autor:
Shilpi Chandra, James Gray, William B. Kiosses, Archana Khurana, Kaori Hitomi, Catherine M. Crosby, Ashu Chawla, Zheng Fu, Meng Zhao, Natacha Veerapen, Stewart K. Richardson, Steven A. Porcelli, Gurdyal Besra, Amy R. Howell, Sonia Sharma, Bjoern Peters, Mitchell Kronenberg
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
The CD1d pathway present lipid antigens resulting in the activation of iNKT cells but the complete pathway remains to be fully elucidated. Here, Chandra et al. use an siRNA screen and identify Mrp1 as crucial for CD1d lipid presentation and activatio
Externí odkaz:
https://doaj.org/article/4dce5c3c771f4a1abdb502245e1a6bb5
Autor:
Cristiano Sacchetti, Yunpeng Bai, Stephanie M. Stanford, Paola Di Benedetto, Paola Cipriani, Eugenio Santelli, Sonsoles Piera-Velazquez, Vladimir Chernitskiy, William B. Kiosses, Arnold Ceponis, Klaus H. Kaestner, Francesco Boin, Sergio A. Jimenez, Roberto Giacomelli, Zhong-Yin Zhang, Nunzio Bottini
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Although protein tyrosine kinases are being explored as antifibrotic agents for the treatment of systemic sclerosis, little is known about the function of counteractive protein tyrosine phosphatases in this context. Here, the authors show that PTP4A1
Externí odkaz:
https://doaj.org/article/bda2249f57354c398a9b7c97bc41a7fd
Autor:
Elena I. Deryugina, William B. Kiosses
Publikováno v:
Cell Reports, Vol 19, Iss 3, Pp 601-616 (2017)
Summary: Intravasation, active entry of cancer cells into the circulation, is often considered to be a relatively late event in tumor development occurring after stromal invasion. Here, we provide evidence that intravasation can be initiated early du
Externí odkaz:
https://doaj.org/article/998c41c344d846cb968ff23e83f17215
Autor:
Ryosuke Saigusa, Payel Roy, Antoine Freuchet, Rishab Gulati, Yanal Ghosheh, Sujit Silas Armstrong Suthahar, Christopher P. Durant, David B. Hanna, William B. Kiosses, Marco Orecchioni, Lai Wen, Runpei Wu, Mark H. Kuniholm, Alan L. Landay, Kathryn Anastos, Phyllis C. Tien, Stephen J. Gange, Seble Kassaye, Jenifer Vallejo, Catherine C. Hedrick, William W. Kwok, Alessandro Sette, Howard N. Hodis, Robert C. Kaplan, Klaus Ley
Publikováno v:
Nat Cardiovasc Res
Atherosclerosis is accompanied by a CD4 T cell response to apolipoprotein B (APOB). Major Histocompatibility Complex (MHC)-II tetramers can be used to isolate antigen-specific CD4 T cells by flow sorting. Here, we produce, validate and use an MHC-II
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cd2538a5cbb8e4f12326b27b40c27dd
https://doi.org/10.1038/s44161-022-00063-3
https://doi.org/10.1038/s44161-022-00063-3
Autor:
Marco Orecchioni, Kouji Kobiyama, Holger Winkels, Yanal Ghosheh, Sara McArdle, Zbigniew Mikulski, William B. Kiosses, Zhichao Fan, Lai Wen, Yunmin Jung, Payel Roy, Amal J. Ali, Yukiko Miyamoto, Matthew Mangan, Jeffrey Makings, Zhihao Wang, Angela Denn, Jenifer Vallejo, Michaela Owens, Christopher P. Durant, Simon Braumann, Navid Mader, Lin Li, Hiroaki Matsunami, Lars Eckmann, Eicke Latz, Zeneng Wang, Stanley L. Hazen, Klaus Ley
Publikováno v:
Science (New York, N.Y.), vol 375, iss 6577
Atherosclerosis is an inflammatory disease of the artery walls and involves immune cells such as macrophages. Olfactory receptors (OLFRs) are G protein–coupled chemoreceptors that have a central role in detecting odorants and the sense of smell. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4fb257ae47bf0fbb6db9e2cd86c7729
https://doi.org/10.1126/science.abg3067
https://doi.org/10.1126/science.abg3067
Autor:
Estefania Quesada-Masachs, Samuel Zilberman, Sakthi Rajendran, Tiffany Chu, Sara McArdle, William B. Kiosses, Jae-Hyun M. Lee, Burcak Yesildag, Mehdi A. Benkahla, Agnieszka Pawlowska, Madeleine Graef, Susanne Pfeiffer, Zbigniew Mikulski, Matthias von Herrath
Publikováno v:
Diabetologia. 65:387-401
We aimed to characterise and quantify the expression of HLA class II (HLA-II) in human pancreatic tissue sections and to analyse its induction in human islets.We immunostained human pancreatic tissue sections from non-diabetic (n = 5), autoantibody p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c2e4aa8d23ba15d37139e447186f4b6
https://doi.org/10.1007/s00125-021-05619-9
https://doi.org/10.1007/s00125-021-05619-9