Zobrazeno 1 - 10
of 993
pro vyhledávání: '"B, Kegel"'
Autor:
Kai Shing, Ellen Sapp, Adel Boudi, Sophia Liu, Connor Seeley, Deanna Marchionini, Marian DiFiglia, Kimberly B. Kegel-Gleason
Publikováno v:
Neurobiology of Disease, Vol 187, Iss , Pp 106313- (2023)
Expansion of a triplet repeat tract in exon 1 of the HTT gene causes Huntington’s disease (HD). The mutant HTT protein (mHTT) has numerous aberrant interactions with diverse, pleiomorphic effects. Lowering mHTT is a promising approach to treat HD,
Externí odkaz:
https://doaj.org/article/c8c24b399d8147d6a817da585ba95743
Autor:
Maria Iuliano, Connor Seeley, Ellen Sapp, Erin L. Jones, Callie Martin, Xueyi Li, Marian DiFiglia, Kimberly B. Kegel-Gleason
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 13 (2021)
Dysfunction at synapses is thought to be an early change contributing to cognitive, psychiatric and motor disturbances in Huntington’s disease (HD). In neurons, mutant Huntingtin collects in aggregates and distributes to the same sites as wild-type
Externí odkaz:
https://doaj.org/article/d9058e7d8ada41e38f8c36f9b8418a92
Autor:
Ellen Sapp, Connor Seeley, Maria Iuliano, Elizabeth Weisman, Petr Vodicka, Marian DiFiglia, Kimberly B. Kegel-Gleason
Publikováno v:
Neurobiology of Disease, Vol 141, Iss , Pp 104950- (2020)
Molecular changes at synapses are thought to underly the deficits in motor and cognitive dysfunction seen in Huntington's disease (HD). Previously we showed in synaptosome preparations age dependent changes in levels of selected proteins examined by
Externí odkaz:
https://doaj.org/article/239a9d9e906a409799b96037810b10cc
Autor:
Adelaide Tousley, Maria Iuliano, Elizabeth Weisman, Ellen Sapp, Heather Richardson, Petr Vodicka, Jonathan Alexander, Neil Aronin, Marian DiFiglia, Kimberly B Kegel-Gleason
Publikováno v:
PLoS ONE, Vol 14, Iss 2, p e0212337 (2019)
One response of cells to growth factor stimulus involves changes in morphology driven by the actin cytoskeleton and actin associated proteins which regulate functions such as cell adhesion, motility and in neurons, synaptic plasticity. Previous studi
Externí odkaz:
https://doaj.org/article/1c4e2374f2a54accbff0457c88ce86cf
Autor:
Ellen Sapp, Kai Shing, Adel Boudi, Sophia Liu, Connor Seeley, Deanna Marchionini, Marian DiFiglia, Kimberly B. Kegel-Gleason
Publikováno v:
bioRxiv
Lowering mutant huntingtin (mHTT) transcription is a promising approach to treat Huntington’s disease (HD). Using a mHtt-inducible mouse model we analyzed mHttlowering initiated at different ages and sustained for different time-periods. mHTT prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf76168d9d0e095d1f1f1a736803f095
https://europepmc.org/articles/PMC9900921/
https://europepmc.org/articles/PMC9900921/
Publikováno v:
Journal of Huntington's Disease
Mass spectrometry (MS) is a physical technique used to identify specific chemicals and molecules by precise analysis of their mass and charge; this technology has been adapted for biological sciences applications. Investigators have used MS to identi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::723ad15e9cbe9391cedaaf4baa170d2c
https://doi.org/10.3233/jhd-200465
https://doi.org/10.3233/jhd-200465
Autor:
Xueyi Li, Ellen Sapp, Kathryn Chase, Laryssa A. Comer-Tierney, Nicholas Masso, Jonathan Alexander, Patrick Reeves, Kimberly B. Kegel, Antonio Valencia, Miguel Esteves, Neil Aronin, Marian DiFiglia
Publikováno v:
Neurobiology of Disease, Vol 36, Iss 2, Pp 374-383 (2009)
The Huntington's disease (HD) mutation causes polyglutamine expansion in huntingtin (Htt) and neurodegeneration. Htt interacts with a complex containing Rab11GDP and is involved in activation of Rab11, which functions in endosomal recycling and neuri
Externí odkaz:
https://doaj.org/article/c495eae392174463946cee4c22162d05
Autor:
Yun J. Kim, Ellen Sapp, Benjamin G. Cuiffo, Lindsay Sobin, Jennifer Yoder, Kimberly B. Kegel, Zheng-Hong Qin, Peter Detloff, Neil Aronin, Marian DiFiglia
Publikováno v:
Neurobiology of Disease, Vol 22, Iss 2, Pp 346-356 (2006)
N-terminal mutant huntingtin (N-mhtt) fragments form inclusions and cause cell death in vitro. Mutant htt expression stimulates autophagy and increases levels of lysosomal proteases. Here, we show that lysosomal proteases, cathepsins D, B and L, affe
Externí odkaz:
https://doaj.org/article/877e860b05cf4a09b15ee4ecb871b503
Autor:
Neil Aronin, Hubert Aviolat, Maria Iuliano, Ningzhe Zhang, Ellen Sapp, Kimberly B. Kegel-Gleason, Lisa M. Ellerby, Patrick Reeves, Leah W. Gatune, Jonathan Alexander, Petr Vodicka, Adelaide Tousley, Elizabeth Weisman, Xueyi Li, Marian DiFiglia, Anastasia Khvorova
Publikováno v:
Journal of Huntington's Disease
Background Previous studies suggest that Huntingtin, the protein mutated in Huntington's disease (HD), is required for actin based changes in cell morphology, and undergoes stimulus induced targeting to plasma membranes where it interacts with phosph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07cb33a169e9cba454c5468eae2b08b8
https://doi.org/10.3233/jhd-180311
https://doi.org/10.3233/jhd-180311
Autor:
Kimberly B. Kegel-Gleason, Connor Seeley, Callie Martin, Xueyi Li, Erin L Jones, Marian DiFiglia, Ellen Sapp, Maria Iuliano
Publikováno v:
Frontiers in Synaptic Neuroscience
Frontiers in Synaptic Neuroscience, Vol 13 (2021)
Frontiers in Synaptic Neuroscience, Vol 13 (2021)
Dysfunction at synapses is thought to be an early change contributing to cognitive, psychiatric and motor disturbances in Huntington’s disease (HD). In neurons, mutant Huntingtin collects in aggregates and distributes to the same sites as wild-type
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7136a7c7762c0b63130fb2318d8364a0
https://doi.org/10.3389/fnsyn.2021.618391
https://doi.org/10.3389/fnsyn.2021.618391