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Increased hexosamine biosynthetic pathway flux dedifferentiates INS-1E cells and murine islets by an extracellular signal-regulated kinase (ERK)1/2-mediated signal transmission pathway

Autor: Luca Ulianich, Giuseppe Nicolardi, Dario Domenico Lofrumento, Francesco Beguinot, Claudia Miele, Antonella Sonia Treglia, Corrado Garbi, Cecilia Nigro, B. Di Jeso, Luca Parrillo, Angela Lombardi

Publikováno v: Diabetologia (Berl.) (2012).
info:cnr-pdr/source/autori:Lombardi A, Ulianich L, Treglia AS, Nigro C, Parrillo L, Lofrumento DD, Nicolardi G, Garbi C, Beguinot F, Miele C, Di Jeso B. Source/titolo:Increased hexosamine biosynthetic pathway flux dedifferentiates INS-1E cells and murine islets by an extracellular signal-regulated kinase (ERK)1%2F2-mediated signal transmission pathway./doi:/rivista:Diabetologia (Berl.)/anno:2012/pagina_da:/pagina_a:/intervallo_pagine:/volume

AIMS/HYPOTHESIS: Beta cell failure is caused by loss of cell mass, mostly by apoptosis, but also by simple dysfunction (decline of glucose-stimulated insulin secretion, downregulation of specific gene expression). Apoptosis and dysfunction are caused

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::634db53341c8f505f7cacf6e724ed465
https://doi.org/10.1007/s00125-011-2315-1

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Glucosamine-induced endoplasmic reticulum stress affects GLUT4 expression via activating transcription factor 6 in rat and human skeletal muscle cells

Autor: Francesco Beguinot, Paola Ungaro, Claudia Iadicicco, Gregory Alexander Raciti, Michael Gaster, Claudia Miele, Luca Ulianich, B. Di Jeso, Michele Longo, Pietro Formisano, Birgitte F. Vind, Raffaele Teperino, Francesco Andreozzi

Publikováno v: Raciti, G A, Iadicicco, C, Ulianich, L, Vind, B F, Gaster, M, Andreozzi, F, Longo, M, Teperino, R, Ungaro, P, Di Jeso, B, Formisano, P, Beguinot, F & Miele, C 2010, ' Glucosamine-induced endoplasmic reticulum stress affects GLUT4 expression via activating transcription factor 6 in rat and human skeletal muscle cells ', Diabetologia, vol. 53, no. 5, pp. 955-65 . https://doi.org/10.1007/s00125-010-1676-1
Diabetologia (Berl.) 53 (2010): 955–965.
info:cnr-pdr/source/autori:Raciti GA; Iadicicco C; Ulianich L; Vind FB; Gaster M; Andreozzi F; longo M; Teperino R; Ungaro P; Di Jeso B; Formisano P; Beguinot F; Miele C./titolo:Glucosamine-induced endoplasmic reticulum stress affects GLUT4 expression via activating transcription factor 6 in rat and human skeletal muscle cells./doi:/rivista:Diabetologia (Berl.)/anno:2010/pagina_da:955/pagina_a:965/intervallo_pagine:955–965/volume:53

AIMS/HYPOTHESIS: Glucosamine, generated during hyperglycaemia, causes insulin resistance in different cells. Here we sought to evaluate the possible role of endoplasmic reticulum (ER) stress in the induction of insulin resistance by glucosamine in sk

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77a59b3b158376d98a76b144af729d60
https://hdl.handle.net/11587/338784

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Differential functions of PKC-δ and PKC-ζ in cisplatin response of normal and transformed thyroid cells

Autor: Antonella Muscella, B. Di Jeso, Francesco Paolo Fanizzi, Carlo Storelli, Santo Marsigliante, Danilo Migoni, Nadia Calabriso, Loredana Urso, Antonella Ciccarese

We investigated the effects of cisplatin (cisPt) in normal PC Cl3 and in transformed and tumourigenic PC E1Araf cells. cisPt cytotoxicity was higher in PC Cl3 than in PC E1Araf cells. In both cell lines, cisPt provoked the ERK1/2 phosphorylation; thi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6c0922fb147ae55dcea08ae8b0e0d34
http://hdl.handle.net/11577/3365276

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The expression of the sarco/endoplasmic reticulum Ca2+-ATPases in thyroid and its down-regulation following neoplastic transformation

Autor: Antonio Leonardi, Eduardo Consiglio, S. Formisano, S De Micheli, Francesco Pacifico, B Di Jeso, Luca Ulianich, Sonia Treglia, Pasquale Vito

Publikováno v: Journal of molecular endocrinology 30 (2003): 399–409.
info:cnr-pdr/source/autori:Pacifico F., Ulianich L., De Micheli S., Treglia S., Leonardi A., Vito P., Formisano S., Consiglio E., Di Jeso B./titolo:The expression of the sarco%2Fendoplasmic reticulum Ca2+-ATPases in thyroid and its down-regulation following neoplastic transformation./doi:/rivista:Journal of molecular endocrinology/anno:2003/pagina_da:399/pagina_a:409/intervallo_pagine:399–409/volume:30

Maintaining a high Ca(2+) concentration in the lumen of the endoplasmic reticulum (ER), by the action of sarco/endoplasmic reticulum Ca(2+)-ATPases (SERCAs), is important in many cellular processes, such as Ca(2+)-mediated cytosolic signaling in resp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e43805b58dbc5ab2036161094a9bc1c5
http://hdl.handle.net/11588/143805

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Inhibition of c-ras reactivates thyroglobulin synthesis in middle-T transformed thyroid cells

Autor: B, Di Jeso, A, Feliciello, F, Pacifico, A, Iannelli, F, D'Armiento, D, Liguoro, P, Giuliano, G, Ferulano, E V, Avvedimento

Publikováno v: Cell growthdifferentiation : the molecular biology journal of the American Association for Cancer Research. 6(10)

Differentiated thyroid cells expressing polyoma Middle-T became transformed and tumorigenic when injected into syngenic animals. The expression of thyroglobulin was greatly reduced and no longer responsive to thyrotropin (TSH) and to cAMP. Inhibition

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3e7c90d32b5ef689dc4a1585c9e00446
https://pubmed.ncbi.nlm.nih.gov/8845309

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Modulation of the carbohydrate moiety of thyroglobulin by thyrotropin and calcium in Fisher rat thyroid line-5 cells

Autor: B, Di Jeso, D, Liguoro, P, Ferranti, M, Marinaccio, R, Acquaviva, S, Formisano, E, Consiglio

Publikováno v: The Journal of biological chemistry. 267(3)

Thyroglobulin secreted in the medium by Fisher rat thyroid line-5 (FRTL-5) cells cultured in the presence of thyroid stimulating hormone (TSH) shows a slower electrophoretic mobility in sodium dodecyl sulfate-polyacrylamide gel electrophoresis and a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::36bce094bd85d54af505b532662800af
https://pubmed.ncbi.nlm.nih.gov/1370485

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Calcium interaction with bovine thyroiglobulin: stoichiometry and structural consequences of calcium binding

Autor: Antonio Leonardi, D. Salvatore, Silvestro Formisano, B Di Jeso, Eduardo Consiglio, Renato Acquaviva, F. Pinto

Gel filtration studies show that the thyroglobulin (Tg) molecule (dimer) binds from 18 to 50 Ca 2+ ions. At pH 7.5 Tg binds 18 Ca 2+ ions with a K d of 1.3 × 10 −5 M, and 50 Ca 2+ ions with a K d of 5.5 × 10 −4 M. The binding of calcium to bovi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5525e7a237b754542a42ab9c4495f9f8
http://hdl.handle.net/11588/163504

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[Effect of diazepam on mitochondrial respiration]

Autor: F, di Jeso, A, Truscello, G, Martinotti, B, di Jeso, B, Magnani, A, Martinotti

Publikováno v: Comptes rendus des seances de la Societe de biologie et de ses filiales. 184(1)

Our hypothesis that the strong effects of neutropic drugs on nervous system have hidden more widespread effects on all tissues and cells, is collecting evidences in our laboratory. We have essayed in vitro benzodiazepines on liver rat mitochondria. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::657cf5c60a38f3ab524dfe43f5f74608
https://pubmed.ncbi.nlm.nih.gov/2150779

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