Pharmacological inhibition of 17 beta-hydroxysteroid dehydrogenase impairs human endometrial cancer growth in an orthotopic xenograft mouse model

Autor: Niina Saarinen, Gonda Konings, Roy F.P.M. Kruitwagen, Enitec, Elisabetta d'Avanzo, Loes F. S. Kooreman, Seppo Auriola, Florian Caiment, Frank Verhaegen, Sofia Xanthoulea, Youssef Walid, B. Delvoux, Natasja G. Lieuwes, Pasi Koskimies, Merja R. Häkkinen, Andrea Romano

Publikováno v: Cancer Letters, 508, 18-29. Elsevier Ireland Ltd

Endometrial cancer (EC) is the most common gynaecological tumor in developed countries and its incidence is increasing. Approximately 80% of newly diagnosed EC cases are estrogen-dependent. Type 1 17 beta-hydroxysteroid dehydrogenase (17 beta-HSD-1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82e8a15cc5c42726c1986f1bc58d06e9
https://doi.org/10.1016/j.canlet.2021.03.019

EP502 Blocking 17b-hydroxysteroid dehydrogenase type 1 in endometrial cancer: a potential novel endocrine therapeutic approach

Autor: Marc Vooijs, Kmc Cornel, Helga B. Salvesen, K Kuijk van, Enitec, B. Delvoux, Roy F.P.M. Kruitwagen, Camilla Krakstad, Marlies Y. Bongers, Loes F. S. Kooreman, Andrea Romano, Yannick Schrooders, Sofia Xanthoulea, Margaretha A. Skowron, P Koskimies, Arjan J. Groot, Gonda Konings

Publikováno v: ePoster.

Introduction/Background The enzyme type 1 17β-hydroxysteroid dehydrogenase (HSD17B1), responsible for generating active 17β-estradiol (E2) from low-active estrone (E1), is over-expressed in endometrial cancer (EC) thus implicating an increased intr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::80913200f320177c5e764ff68680a42d
https://doi.org/10.1136/ijgc-2019-esgo.560

High mRNA levels of 17 beta-hydroxysteroid dehydrogenase type 1 correlate with poor prognosis in endometrial cancer

Autor: Camilla Krakstad, Helga B. Salvesen, Gonda Konings, B. Delvoux, Marlies Y. Bongers, Sofia Xanthoulea, Loes F. S. Kooreman, Enitec, Roy F.P.M. Kruitwagen, Andrea Romano, Balazs Jori, Karlijn M. C. Cornel

Publikováno v: Molecular and Cellular Endocrinology, 442(C), 51-57. Elsevier Ireland Ltd

Most endometrial cancers (ECs) are diagnosed at an early stage and have a good prognosis. However, 20-30% develop recurrence and have poor survival. Recurrence-risk prediction at diagnosis is hampered by the scarcity of prognostic markers.Most ECs ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51bc076f243ee38d4a4db0aa5a8972f5
https://cris.maastrichtuniversity.nl/en/publications/ef1e8431-4655-49c4-996e-4e75911d5739

Paired-box gene 2 is down-regulated in endometriosis and correlates with low epidermal growth factor receptor expression

Autor: Cleophas M. Kyama, K K Van de Vijver, A.A. de Graaff, Andrea Romano, B. Delvoux, Thomas D'Hooghe, Gerard A.J. Dunselman

Publikováno v: Human Reproduction, 27(6), 1676-1684. Oxford University Press

background: Paired-box 2 (Pax2) is involved in the development of the female genital tract and has been associated with endometrial pathologies. The expression of Pax2 is induced by epidermal growth factor (EGF) and estrogens. In the present study, P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22c7a595cc8c1950c420a4cc3e63296e
https://doi.org/10.1093/humrep/des124

Posters * Endometriosis, Endometrium and Implantation

Autor: Y. Jiang, J. Zhao, M. Hua, X. Zhen, G. Yan, Y. Hu, H. Sun, L. Selvaggi, G. F. Zannoni, V. Tagliaferri, S. De Cicco, V. G. Vellone, D. Romualdi, A. Lanzone, M. Guido, A. Fassbender, A. V. Vodolazkaia, X. B. Bossuyt, M. K. Kyama, C. M. Meuleman, K. P. Peeraer, C. T. Tomassetti, T. M. D'Hooghe, A. Lumini, L. Nanni, C. Manna, S. Pappalardo, A. Melin, C. Lundholm, N. Malki, M. L. Swahn, P. Sparen, A. Bergqvist, F. Crescenzi, A. Farrag, H. N. Sallam, L. Zou, G. Ding, R. Zhang, J. Sheng, H. Huang, C. von Kleinsorgen, T. Wilson, U. Thiel-Moder, A. D. Ebert, M. Reinfandt, T. Papadopolous, A. S. Melo, J. K. Rodrigues, L. A. Dib, A. Z. Andrade, F. C. Donabela, R. A. Ferriani, P. A. Navarro, A. Tocci, P. Royo, C. Lucchini, P. Ramos, J. L. Alcazar, T. Habara, S. Terada, N. Yoshioka, N. Hayashi, D. Haouzi, S. Assou, C. Monzo, T. Anahory, H. Dechaud, J. De Vos, S. Hamamah, R. Gonzalez-Ramos, C. Rojas, J. Rocco, A. Poch, H. Sovino, P. Kohen, A. Munoz, L. Devoto, M. A. Aygen, T. Atakul, G. Oner, M. T. Ozgun, Y. Sahin, F. Ozturk, R. Li, J. Qiao, I. Zhylkova, A. Feskov, I. Feskova, O. Somova, N. Chumakova, S. Bontekoe, D. Blake, M. J. Heineman, E. C. Williams, N. P. Johnson, A. Motta, D. Colaci, M. Horton, M. Faut, C. Bisioli, L. Kopcow, I. de Zuniga, Z. Wiener-Megnazi, M. Khaytov, S. Lahav - Baratz, H. Shiloh, M. Koifman, R. Oslander, M. Dirnfeld, J. Sundqvist, K. L. Andersson, G. Scarselli, K. Gemzell-Danielsson, P. G. L. Lalitkumar, N. Tokushige, R. Markham, B. Crossett, S. Ahn, V. Nelaturi, A. Khan, I. S. Fraser, I. Van Vaerenbergh, H. M. Fatemi, C. Blockeel, L. Van Lommel, P. In't Veld, F. Schuit, E. M. Kolibianakis, P. Devroey, C. Bourgain, N. Sugino, I. Tamura, R. Lee, R. Maekawa, T. Gelbaya, S. Gordts, T. N. D'Hooghe, M. Gergolet, L. G. Nardo, H. Yu, H. Wang, C. Lee, Y. Soong, Y. Kremenska, Y. Masliy, Y. Goncharova, M. Kremenskoy, V. Veselovskyy, V. Zukin, I. Sudoma, F. Delgado-Rosas, R. Gomez, S. Tamarit, A. Abad, C. Simon, A. Pellicer, M. Racicot, N. L. Dean, R. Antaki, S. Menard, I. J. Kadoch, R. Garcia-Guzman, L. Cabrera Romero, J. Hernandez, A. Palumbo, E. Marshall, J. Lowry, J. A. Maybin, F. Collins, H. O. D. Critchley, P. T. K. Saunders, K. Chaudhury, S. K. Jana, P. Banerjee, S. Mukherjee, B. N. Chakravarty, A. Allegra, A. Marino, A. Lama, A. Santoro, C. Agueli, S. Mazzola, A. Volpes, B. Delvoux, A. A. de Graaff, C. M. Kyama, G. A. J. Dunselman, A. Romano, D. Caccavo, N. M. Pellegrino, I. Totaro, M. Panzarino, C. Nardelli, R. Depalo, R. Flores, V. Montanana, A. Monzo, P. Polo, T. Garcia-Gimeno, A. Cabo, J. M. Rubio, G. L. Beets, J. J. van Lankveld, H. Y. Kim, B. S. Lee, S. H. Cho, Y. S. Choi, S. K. Seo, K. E. Lee, H. I. Yang, A. Abubakirov, T. Vacheyshvili, L. Krechetova, M. Ziganshina, T. Demura, T. Nazarenko, I. Fulop, A. Rucz, S. Z. Herczegh, A. Ujvari, S. Z. Takacs, T. Szakonyi, A. Lopez - Muniz, L. Zamora, O. Serra, C. Guix, M. Lopez-Teijon, C. Benadiva, J. G. Alvarez, M. Goudakou, A. Karkanaki, A. Kalogeraki, I. Mataliotakis, I. Kalogiannidis, I. Prapas, M. Hosie, K. J. Thomson, C. B. Penny, C. Penny, M. J. Hosie, B. McKinnon, B. Klaeser, N. Bersinger, M. D. Mueller, J. A. Horcajadas, J. A. Martinez-Conejero, M. Montesinos, M. Morgan, S. Fortuno, K. W. Yi, J. H. Shin, H. T. Park, T. Kim, S. H. Kim, J. Y. Hur, R. W. S. Chan, Y. Y. Chan, E. H. Y. Ng, W. S. B. Yeung, P. Santulli, B. Borghese, N. Chopin, L. Marcellin, D. de Ziegler, C. Chapron, A. Elnashar, A. Badawy, A. Mosbah, S. Tzioras, N. P. Polyzos, C. I. Messini, E. G. Papanikolaou, A. Valachis, E. Patavoukas, D. Mauri, I. E. Messinis, N. Acar, Y. Hirota, S. Tranguch, T. Daikoku, K. E. Burnum, H. Xie, A. Kodama, Y. Osuga, I. Ustunel, D. B. Friedman, R. M. Caprioli, S. K. Dey, A. Mitra, R. Sahu, M. Pal, A. K. Bhattachrayya, J. Bhattachrya, S. Ferrero, V. Remorgida, G. A. Rollandi, E. Biscaldi, S. Cho, E. Arena, A. Morando, T. Tomazevic, H. Ban-Frangez, I. Virant-Klun, I. Verdenik, B. Pozlep, E. Vrtacnik-Bokal, M. Valenzano Menada, M. Morotti, P. L. Venturini, E. Dimitriadis, L. A. Salamonsen, N. Hannan, O. O'Connor, L. Rombauts, C. Stoikos, M. Mahmoudi, A. Shaikh, N. Mousavifar, M. Rastin, J. Baharara, N. Tabasi, Y. Takemura, A. Fujimoto, R. Tsutsumi, N. Ooi, T. Yano, Y. Taketani, I. Panagiotidis, Y. Prapas, D. Zhang, P. P. Lv, G. L. Ding, R. J. Zhang, L. B. Zou, G. F. Xu, H. J. Gao, Y. M. Zhu, J. Z. Sheng, H. F. Huang, E. Labarta, P. Alama, E. Bosch

Publikováno v: Human Reproduction. 25:i210-i235

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bab061e56b1e3c327652712ba9e8faf6
https://doi.org/10.1093/humrep/de.25.s1.242