Zobrazeno 1 - 10
of 481
pro vyhledávání: '"B, Cines"'
Platelet factor 4 (CXCL4/PF4) upregulates matrix metalloproteinase-2 (MMP-2) in gingival fibroblasts
Autor:
Hoa T. Le, Kalyan Golla, Ryan Karimi, Michael R. Hughes, Flavia Lakschevitz, Douglas B. Cines, M. Anna Kowalska, Mortimer Poncz, Kelly M. McNagny, Lari Häkkinen, Hugh Kim
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Periodontitis is a chronic inflammatory disease characterized by the release of matrix metalloproteinases (MMPs) from resident connective tissue cells in tooth-supporting tissues (periodontium). Platelet activation, and the attendant release
Externí odkaz:
https://doaj.org/article/c2467ba58de749a98460d3e7a5fb6c55
Autor:
Yi Na Dong, Fu-Chun Hsu, Cynthia J. Koziol-White, Victoria Stepanova, Joseph Jude, Andrei Gritsiuta, Ryan Rue, Rosalind Mott, Douglas A. Coulter, Reynold A. Panettieri, Vera P. Krymskaya, Hajime Takano, Elena A. Goncharova, Dmitry A. Goncharov, Douglas B. Cines, David R. Lynch
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract N-methyl-d-aspartate (NMDA) receptors are widely expressed in the central nervous system. However, their presence and function at extraneuronal sites is less well characterized. In the present study, we examined the expression of NMDA recept
Externí odkaz:
https://doaj.org/article/8bd4b029a3e741f88fc9ecbfcf332be3
Autor:
Irina N. Chernysh, Chandrasekaran Nagaswami, Sofia Kosolapova, Alina D. Peshkova, Adam Cuker, Douglas B. Cines, Carolyn L. Cambor, Rustem I. Litvinov, John W. Weisel
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Abstract Although arterial and venous thromboembolic disorders are among the most frequent causes of mortality and morbidity, there has been little description of how the composition of thrombi and emboli depends on their vascular origin and age. We
Externí odkaz:
https://doaj.org/article/12086ecd9aa2460989bafb505ae629db
Autor:
Cindy Neunert, Deirdra R. Terrell, Donald M. Arnold, George Buchanan, Douglas B. Cines, Nichola Cooper, Adam Cuker, Jenny M. Despotovic, James N. George, Rachael F. Grace, Thomas Kühne, David J. Kuter, Wendy Lim, Keith R. McCrae, Barbara Pruitt, Hayley Shimanek, Sara K. Vesely
Publikováno v:
Blood Advances, Vol 3, Iss 23, Pp 3829-3866 (2019)
Abstract: Background: Despite an increase in the number of therapies available to treat patients with immune thrombocytopenia (ITP), there are minimal data from randomized trials to assist physicians with the management of patients.Objective: These e
Externí odkaz:
https://doaj.org/article/61b0918c8aaf4076a09ba65bc53595e5
Autor:
Douglas B. Cines, Andreas Greinacher
Publikováno v:
Blood. 141:1659-1665
Within the first months of the COVID-19 vaccination campaign, previously healthy recipients who developed severe thrombosis (often cerebral and/or splanchnic vasculature) and thrombocytopenia typically after adenoviral vector-based vaccination were i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6502d38ca73b4d41043156218cbed9d
https://doi.org/10.1182/blood.2022017696
https://doi.org/10.1182/blood.2022017696
Autor:
Zheng Cai, Khalil Bdeir, Serge V. Yarovoi, Lubica Rauova, Gowthami M. Arepally, Sanjay Khandelwal, Jerome Rollin, Yves Gruel, Sergei Zaitsev, Mortimer Poncz, Mark I. Greene, Douglas B. Cines
Publikováno v:
Journal of Thrombosis and Haemostasis. 21:652-666
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97196fa1556c55e8d6f2bd87aa40e34a
https://doi.org/10.1016/j.jtha.2022.11.043
https://doi.org/10.1016/j.jtha.2022.11.043
Autor:
Galina Florova, René A. Girard, Ali O. Azghani, Krishna Sarva, Ann Buchanan, Sophia Karandashova, Christian J. DeVera, Danna Morris, Mignote Chamiso, Kathleen Koenig, Douglas B. Cines, Steven Idell, Andrey A. Komissarov
Publikováno v:
Physiological Reports, Vol 9, Iss 9, Pp n/a-n/a (2021)
Abstract Plasminogen activator inhibitor‐1 (PAI‐1) is an endogenous irreversible inhibitor of tissue‐type (tPA) and urokinase (uPA) plasminogen activators. PAI‐1‐targeted fibrinolytic therapy (PAI‐1‐TFT) is designed to decrease the ther
Externí odkaz:
https://doaj.org/article/386765511fda4d219e19f23621bdbcd5
Autor:
Mohamed Higazi, Suhair Abdeen, Rami Abu-Fanne, Samuel N Heyman, Aseel Masarwy, Khalil Bdeir, Emad Maraga, Douglas B Cines, Abd Al-Roof Higazi
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0231582 (2020)
Atherosclerosis, the predominant cause of death in well-resourced countries, may develop in the presence of plasma lipid levels within the normal range. Inflammation may contribute to lesion development in these individuals, but the underlying mechan
Externí odkaz:
https://doaj.org/article/7edbc5b3d3f044a396aa794b28049bca
Autor:
Carlos H. Villa, Daniel C. Pan, Ian H. Johnston, Colin F. Greineder, Landis R. Walsh, Elizabeth D. Hood, Douglas B. Cines, Mortimer Poncz, Don L. Siegel, Vladimir R. Muzykantov
Publikováno v:
Blood Advances, Vol 2, Iss 3, Pp 165-176 (2018)
Abstract: Carriage of drugs by red blood cells (RBCs) modulates pharmacokinetics, pharmacodynamics, and immunogenicity. However, optimal targets for attaching therapeutics to human RBCs and adverse effects have not been studied. We engineered nonhuma
Externí odkaz:
https://doaj.org/article/a2921fc5daff4bd8bbb9bbefa4a0a492
Autor:
Ayiesha P. Barnes, Sanjay Khandelwal, Simone Sartoretto, Sooho Myoung, Samuel J. Francis, Grace M. Lee, Lubica Rauova, Douglas B. Cines, Jon T. Skare, Charles E. Booth, Brandon L. Garcia, Gowthami M. Arepally
Publikováno v:
Journal of Thrombosis and Haemostasis. 20:2656-2665
Anti-platelet factor 4 (PF4)/heparin immune complexes that cause heparin-induced thrombocytopenia (HIT) activate complement via the classical pathway. Previous studies have shown that the alternative pathway of complement substantially amplifies the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1af7278bda1c148db6da357774b31c0
https://doi.org/10.1111/jth.15856
https://doi.org/10.1111/jth.15856