The chemotherapeutic CX-5461 primarily targets TOP2B and exhibits selective activity in high-risk neuroblastoma

Autor: Min Pan, William C. Wright, Richard H. Chapple, Asif Zubair, Manbir Sandhu, Jake E. Batchelder, Brandt C. Huddle, Jonathan Low, Kaley B. Blankenship, Yingzhe Wang, Brittney Gordon, Payton Archer, Samuel W. Brady, Sivaraman Natarajan, Matthew J. Posgai, John Schuetz, Darcie Miller, Ravi Kalathur, Siquan Chen, Jon Patrick Connelly, M. Madan Babu, Michael A. Dyer, Shondra M. Pruett-Miller, Burgess B. Freeman, Taosheng Chen, Lucy A. Godley, Scott C. Blanchard, Elizabeth Stewart, John Easton, Paul Geeleher

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)

CX-5461 recently progressed through phase I clinical trial as a first-inhuman inhibitor of RNA-POL I. Here, the authors demonstrate that CX-5461 synergizes with topoisomerase I inhibitors to inhibit neuroblastoma cells and that its primary target in

Externí odkaz: https://doaj.org/article/eab356ebc3d24e3c88297e4fc7fbc176

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Probing Gluon Spin-Momentum Correlations in Transversely Polarized Protons through Midrapidity Isolated Direct Photons in p↑+p Collisions at s=200 GeV

Autor: S. F. Pate, Y. L. Yamaguchi, C. Xu, D. Ivanishchev, V. Papavassiliou, Hari Guragain, C. E. Perezlara, H. Asano, A. Sexton, T. Murakami, P. Montuenga, Y. Riabov, R. Seto, N. Grau, T. W. Danley, Takafumi Niida, J. Huang, A. Franz, J. Runchey, A. Sen, Prakhar Garg, K. A. Drees, N. Feege, Kenta Shigaki, R. Cervantes, Iu. Mitrankov, L. Zou, J. Bryslawskyj, J. E. Frantz, D. Reynolds, M. Rosati, B. Mulilo, Sándor Lökös, Tamás Csörgő, K. N. Barish, A. S. Nyanin, J. Klatsky, S. Zharko, N. Cronin, A. Deshpande, Dillon Scott Fitzgerald, Kei Nagashima, M. Snowball, D. McGlinchey, R. A. Soltz, N. Ramasubramanian, H. En'yo, Alexei Khanzadeev, M. J. Leitch, V. Canoa Roman, John Hill, M. Tomášek, D. E. Fields, X. Jiang, Rachid Nouicer, Xiong Wang, A. N. Zelenski, S. P. Sorensen, B. Kurgyis, B. V. Jacak, Minghui Liu, Brajesh K. Singh, G. J. Ottino, Toru Sugitate, W. Peng, P. W. Stankus, Kensuke Homma, I. J. Choi, M. L. Brooks, L. Bichon, C. L. Woody, M. Alfred, M. Grosse Perdekamp, Kenneth Francis Read, Y. J. Kwon, J. B. Choi, X. He, A. Berdnikov, Y. H. Leung, Raphael Noel Tieulent, A. V. Kazantsev, F. Giordano, Satoshi Sato, S. Kudo, R. Corliss, N. S. Bandara, Vladimir Samsonov, Christine Nattrass, T. Hachiya, S. K. Park, M. I. Nagy, Dipak Kumar Mishra, Kenichi Imai, Petr Gallus, T. O. S. Haseler, D. A. Loomis, D. Kapukchyan, Jong-Min Park, Taku Gunji, G. D. N. Perera, Qiao Xu, David Olle Rickard Silvermyr, Y. Goto, M. Phipps, Motoi Inaba, T. Nagashima, Y. Fukuda, I. V. Sourikova, Hideki Hamagaki, W. Fan, G. David, T. Todoroki, E. J. Mannel, K. I. Hahn, J. G. Lajoie, S. Lee, Jennifer E. Perry, Xiao-yan Li, Alexander Milov, J. Hanks, Hiroyuki Sako, M. Patel, N. Apadula, A. Durum, A. Iordanova, Keiji Nagai, A. Drees, S. H. Lim, S. Y. Han, Z. Ji, D. Yu Peressounko, A. Yanovich, I. Nakagawa, Z. Rowan, Dennis Perepelitsa, M. Mendoza, S. Karthas, J. L. Nagle, C. Pinkenburg, D. Kotov, D. S. Jumper, Kyoichiro Ozawa, D. P. Morrison, A. Sukhanov, K. Kurita, S. Campbell, M. Csanad, S. P. Stoll, G. Nukazuka, Min-Hye Kim, G. Tarnai, H. Ge, K. Nakano, Z. Sun, W. E. Sondheim, Arkadiy Taranenko, S. H. Lee, I. Tserruya, M. Jezghani, D. Larionova, T. Majoros, D. Sharma, V. Singh, A. Hodges, T. Shioya, R. Esha, S. D. Rolnick, M. Slunečka, P. L. McGaughey, S. Tarafdar, V. Babintsev, N. Novitzky, R. P. Pisani, T. Koblesky, T. Moon, Senta Greene, Viktor Riabov, Serpil Yalcin, M. Sarsour, D. Jouan, Y. Corrales Morales, V. Bumazhnov, S. Nelson, Byung-Sik Hong, B. Fadem, E. O'Brien, K. L. Smith, M. Harvey, U. Acharya, M. McCumber, Anne Marie Sickles, J. Murata, Chong Kim, A. Bazilevsky, S. Bathe, M. Chiu, Dmitry Blau, B. Schaefer, C. P. Wong, P. V. Radzevich, M. Connors, T. A. Shibata, W. A. Zajc, L. Xue, Alexandre Lebedev, C. A. Ogilvie, T. K. Hemmick, E. J. Desmond, Eunja Kim, A. Denisov, J. S. Bok, G. Mitsuka, A. Pun, J. H. Kang, J. S. Haggerty, Sergey Fokin, K. DeBlasio, D. Isenhower, Tamas Novak, Balazs Ujvari, M. Giles, M. Mitrankova, I. E. Yushmanov, C. Gal, Klaus Dehmelt, Julia Velkovska, A. Khatiwada, D. Dixit, S. Mizuno, M. Beaumier, H. W. Van Hecke, B. Blankenship, Agneta Oskarsson, D. Kincses, John Matthew Durham, Y. Berdnikov, Y. Akiba, C. McKinney, Vaclav Vrba, K. Hill, Maya Hachiya Shimomura, R. S. Hollis, Y. I. Makdisi, M. M. Mondal, M. J. Tannenbaum, B. K. Schmoll, S. Esumi, Martin Purschke, C. A. Aidala, Alice Mignerey, S. Miyasaka, Shoichi Hasegawa, Takao Sakaguchi, A. D. Frawley, V. Andrieux, S. Huang, V. Khachatryan, A. Kingan, H. F. Hamilton, D. Kawall, B. Azmoun, K. Tanida, E. Kistenev, J. H. Yoo, R. Belmont, Zvi Hirsh Citron, P. Kline, A. Dion, I. Shein, J. Sun, V. R. Loggins, J. T. Mitchell, K. Sedgwick, N. Hotvedt, R. Seidl, Vladislav Manko, Mihael Makek, H. Yamamoto, C. L. Silva, A. Enokizono, Y. Watanabe, V. Pantuev, R. S. Towell, A. Timilsina, K. Lovasz, D. Lynch, M. Potekhin, T. Hoshino, D. Richford, A. S. Safonov, Yoshifumi Ueda, J. H. Do, C. L. Towell, N. Vukman, Timothy Thomas Rinn, H. Yu, T. Sumita, C. Y. Chi, M. S. Daugherity, C. P. Singh, J. D. Osborn, Inseok Yoon, R. Petti, B. M. Johnson, N. A. Lewis, M. Finger, J. Sziklai, M. Virius, J. D. Orjuela Koop, Prashant Shukla

Publikováno v: Physical Review Letters. 127

Studying spin-momentum correlations in hadronic collisions offers a glimpse into a three-dimensional picture of proton structure. The transverse single-spin asymmetry for midrapidity isolated direct photons in p ↑ + p collisions at s = 200 GeV is m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1cf860054375cd378c3408b16c19964b
https://doi.org/10.1103/physrevlett.127.162001