Zobrazeno 1 - 10 of 150 pro vyhledávání: '"B, Billing"'
1
Pharmacological Characterization of a Novel Neuroactive Steroid Prodrug, NTS-104, and Its Neuroprotective Activity in Experimental Stroke Models
Autor: Li Zhang, Robin Schwartz-Byrne, Steven Gertz, Matthew McGuire, Colleen Woodhouse, Brianna Powell, Min Wei, Chao Li, Clare B. Billing, Todd A. Verdoorn, Leslie Lam, Tom J. Parry, Benjamin Buller, Zheng Gang Zhang, David Poulsen, Michael Chopp
Publikováno v: Stroke. 53:3455-3464
Background: Ischemic stroke affects about 700 000 patients per year in the United States, and to date, there are no effective pharmacological agents that promote recovery. Here, we studied the pharmacokinetics, pharmacodynamics, and efficacy of NTS-1
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b70c0edd55732f1f4e46ab473556c0c
https://doi.org/10.1161/strokeaha.122.038507
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2
Urinary Leukotriene E 4 and Prostaglandin D 2 Metabolites Increase in Adult and Childhood Severe Asthma Characterized by Type 2 Inflammation. A Clinical Observational Study
Autor: Johan Kolmert, Cristina Gómez, David Balgoma, Marcus Sjödin, Johan Bood, Jon R. Konradsen, Magnus Ericsson, John-Olof Thörngren, Anna James, Maria Mikus, Ana R. Sousa, John H. Riley, Stewart Bates, Per S. Bakke, Ioannis Pandis, Massimo Caruso, Pascal Chanez, Stephen J. Fowler, Thomas Geiser, Peter Howarth, Ildikó Horváth, Norbert Krug, Paolo Montuschi, Marek Sanak, Annelie Behndig, Dominick E. Shaw, Richard G. Knowles, Cécile T. J. Holweg, Åsa M. Wheelock, Barbro Dahlén, Björn Nordlund, Kjell Alving, Gunilla Hedlin, Kian Fan Chung, Ian M. Adcock, Peter J. Sterk, Ratko Djukanovic, Sven-Erik Dahlén, Craig E. Wheelock, H. Ahmed, C. Auffray, A. T. Bansal, E. H. Bel, J. Bigler, B. Billing, F. Baribaud, H. Bisgaard, M. J. Boedigheimer, K. Bønnelykke, J. Brandsma, P. Brinkman, E. Bucchioni, D. Burg, A. Bush, A. Chaiboonchoe, C. H. Compton, J. Corfield, D. Cunoosamy, A. D’Amico, B. De Meulder, V. J. Erpenbeck, D. Erzen, K. Fichtner, N. Fitch, L. J. Fleming, E. Formaggio, U. Frey, M. Gahlemann, V. Goss, Y. Guo, S. Hashimoto, J. Haughney, P. W. Hekking, T. Higenbottam, J. M. Hohlfeld, A. J. Knox, N. Lazarinis, D. Lefaudeux, M. J. Loza, R. Lutter, A. Manta, S. Masefield, J. G. Matthews, A. Mazein, A. Meiser, R. J. M. Middelveld, M. Miralpeix, N. Mores, C. S. Murray, J. Musial, D. Myles, L. Pahus, S. Pavlidis, A. Postle, P. Powel, G. Praticò, M. PuigValls, N. Rao, A. Roberts, G. Roberts, A. Rowe, T. Sandström, J. P. R. Schofield, W. Seibold, A. Selby, R. Sigmund, F. Singer, P. J. Skipp, M. Smicker, K. Sun, B. Thornton, M. Uddin, W. M. van Aalderen, M. van Geest, J. Vestbo, N. H. Vissing, A. H. Wagener, S. S. Wagers, Z. Weiszhart, S. J. Wilson, J. Östling
Publikováno v: U-BIOPRED Study Group 2020, ' Urinary Leukotriene E 4 and Prostaglandin D 2 Metabolites Increase in Adult and Childhood Severe Asthma Characterized by Type 2 Inflammation. A Clinical Observational Study. ', American Journal of Respiratory and Critical Care Medicine, vol. 203, no. 1, pp. 37-53 . https://doi.org/10.1164/rccm.201909-1869OC
American Journal of Respiratory and Critical Care Medicine
American Journal of Respiratory and Critical Care Medicine, 2021, 203 (1), pp.37-53. ⟨10.1164/rccm.201909-1869OC⟩
Rationale: New approaches are needed to guide personalized treatment of asthma. Objectives: To test if urinary eicosanoid metabolites can direct asthma phenotyping. Methods: Urinary metabolites of prostaglandins (PGs), cysteinyl leukotrienes (CysLTs)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91e52ab64017bba43414900205d8dbd0
https://doi.org/10.1164/rccm.201909-1869OC
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3
Multiple-dose ponezumab for mild-to-moderate Alzheimer's disease: Safety and efficacy
Autor: Sharon Cohen, Qinying Zhao, Carol Cronenberger, Aaron H. Burstein, Pamela F. Schwartz, William T. Duggan, Martin M. Bednar, Kejal Kantarci, Clifford R. Jack, Brendon Binneman, Scot Styren, Jae-Hong Lee, Jaren W. Landen, Clare B. Billing, Ken J. Sprenger, Catherine Sattler
Publikováno v: Alzheimer's & Dementia : Translational Research & Clinical Interventions
Introduction Multiple intravenous doses of ponezumab, an anti-amyloid antibody, were evaluated in subjects with mild-to-moderate Alzheimer's disease (AD). Methods In part A, 77 subjects were randomized to ponezumab 0.1, 0.5, or 1 mg/kg (75 treated) a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5783ab75f707d14e03dc8c2932164ab
https://doi.org/10.1016/j.trci.2017.04.003
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4
Development of a straightforward and sensitive scale for MCI and early AD clinical trials
Autor: Clare B. Billing, Alzheimer’s Disease Neuroimaging Initiative, R.J. Anziano, Kaori Ito, Yifan Huang
Publikováno v: Alzheimer's & Dementia. 11:404-414
Background Although the Clinical Dementia Rating Scale-Sum of Boxes score (CDR-SB) is a widely accepted and commonly used global scale, validated clinical endpoints of cognitive changes are unavailable in the predementia stages of Alzheimer's disease
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c27fd3575ca21ec4b452b23479792c4
https://doi.org/10.1016/j.jalz.2014.03.008
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5
A Multicenter, Double-Blind, Placebo-Controlled Trial of the PDE9A Inhibitor, PF-04447943, in Alzheimer’s Disease
Autor: Larry D. Altstiel, Clare B. Billing, Wendy Davidson, Elias Schwam, Robert Chew, Timothy Nicholas, Darlene Ambrose
Publikováno v: Current Alzheimer Research. 11:413-421
Background: PF-04447943 is a potent, selective phosphodiesterase 9A (PDE9A) inhibitor that elevates guanoscine 3’,5’ – cyclic monophosphate (cGMP) in brain and cerebrospinal fluid. PDE9A inhibition enhances synaptic plasticity and improves memo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fac050956a2e6af6835e3d152787ed80
https://doi.org/10.2174/1567205011666140505100858
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6
Safety and Pharmacology of a Single Intravenous Dose of Ponezumab in Subjects With Mild-to-Moderate Alzheimer Disease
Autor: Michael Borrie, James Kupiec, Kelly R. Bales, Clare B. Billing, Michael Woodward, Qinying Zhao, Jerry Yang, Jaren W. Landen, Sharon Cohen, Martin M. Bednar, Christine Alvey, Fred McCush
Publikováno v: Clinical Neuropharmacology. 36:14-23
Objectives Ponezumab is a humanized antiamyloid beta (Aβ) monoclonal antibody designed to treat Alzheimer disease (AD). Methods This randomized, double-blind, single-dose-escalation study evaluated the safety, pharmacokinetics, and pharmacodynamics
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85396b2db21a028fbfef2d4321903387
https://doi.org/10.1097/wnf.0b013e31827db49b
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7
The efficacy and safety of varenicline for smoking cessation using a flexible dosing strategy in adult smokers: a randomized controlled trial
Autor: Douglas E. Jorenby, John E. Pappas, Raymond Niaura, J. Taylor Hays, Frank T. Leone, Clare B. Billing, Karen R. Reeves, Kathryn E. Williams
Publikováno v: Current Medical Research and Opinion. 24:1931-1941
To determine whether self-regulated flexible dosing with varenicline tartrate is safe and effective for smoking cessation.320 healthy, motivated-to-quit smokers (or =10 cigarettes/day) aged 18-65 years, entered a multicenter, randomized, double-blind
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b95754566b0c7521f94fef66c3024881
https://doi.org/10.1185/03007990802177523
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8
A double-blind study evaluating the long-term safety of varenicline for smoking cessation
Autor: Clare B. Billing, Ann M. Pennington, Kathryn E. Williams, Karen R. Reeves, Jason Gong
Publikováno v: Current Medical Research and Opinion. 23:793-801
We assessed the safety of long-term varenicline administration for smoking cessation.In this randomized, double-blind, multicenter trial, eligible adult smokers (18-75 years) who smoked an average ofor =10 cigarettes/day were randomized to either var
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50889f388d636374ce345c8a8a537871
https://doi.org/10.1185/030079907x182185
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9
Should troponin and creatinine kinase be routinely measured after vascular surgery?
Autor: Alan B. Miller, Anne B. Cropp, Emile R. Mohler, Srinivas Mantha, Clare B. Billing, Lisa St Aubin, Don Poldermans, Lee A. Fleisher
Publikováno v: Vascular Medicine, 12(3), 175-181. SAGE Publications Ltd
The current guidelines for the evaluation and prediction of adverse cardiovascular events (CVEs) following vascular surgery in high-risk patients recommends serial electrocardiograms (ECGs) but not biomarkers such as cTn-I and CK-MB. The objective of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d853e72db7190e7621041c4eaad278a
https://doi.org/10.1177/1358863X07081139
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