Zobrazeno 1 - 10
of 41
pro vyhledávání: '"B, Benowitz"'
Autor:
Aidan G. Gilmartin, Arthur Groy, Elizabeth R. Gore, Charity Atkins, Edward R. Long, Monica N. Montoute, Zining Wu, Wendy Halsey, Dean E. McNulty, Daniela Ennulat, Lourdes Rueda, Melissa Pappalardi, Ryan G. Kruger, Michael T. McCabe, Ali Raoof, Roger Butlin, Alexandra Stowell, Mark Cockerill, Ian Waddell, Donald Ogilvie, Juan Luengo, Allan Jordan, Andrew B. Benowitz
Publikováno v:
Haematologica, Vol 106, Iss 7 (2020)
Pharmacological induction of fetal hemoglobin (HbF) expression is an effective therapeutic strategy for the management of beta-hemoglobinopathies such as sickle cell disease. DNA methyltransferase (DNMT) inhibitors 5-azacytidine (5-aza) and 5-aza-2
Externí odkaz:
https://doaj.org/article/375cf7300ce44f4d81582faca63eef19
Autor:
Peter A. Jones, Ashley K. Wiseman, Helai P. Mohammad, Christopher S. Kershaw, Bryan W. King, Ian D. Waddell, Thau F. Ho, Stephen B. Baylin, Morris Muliaditan, Marcus Bantscheff, Elisabeth A. Minthorn, Thilo Werner, Alan P. Graves, Wendy A. Kellner, Phil Chapman, Mehul Patel, Anthony J. Jurewicz, Allan M. Jordan, Emma E. Fairweather, Rab K. Prinjha, Nino Campobasso, Anna Rutkowska, H. Christian Eberl, Ryan G. Kruger, Charles F. McHugh, Michael T. McCabe, Kristin M. Goldberg, Jon Paul Jaworski, Christopher L. Carpenter, Michael Steidel, Stuart Paul Romeril, Dirk A. Heerding, Lourdes Rueda, David T. Fosbenner, Amy N. Taylor, Jacques Briand, Shawn W. Foley, Arthur Groy, Andrew B. Benowitz, Xiaodong Cheng, Donald J. Ogilvie, Paola Grandi, Cunyu Zhang, Mei Li, Sarath Pathuri, Aidan G. Gilmartin, Christian S. Sherk, Juan I. Luengo, Mark Cockerill, Ali Raoof, Alexandra Stowell, Kathryn Keenan, Melissa B. Pappalardi, Makda Mebrahtu, Kristen Wong, Xing Zhang, Jessica L. Handler, Roger J. Butlin, John R. Horton, Susan Merrihew, Charlotte Burt, Dean E. McNulty
Publikováno v:
Nature Cancer. 2:1002-1017
DNA methylation, a key epigenetic driver of transcriptional silencing, is universally dysregulated in cancer. Reversal of DNA methylation by hypomethylating agents, such as the cytidine analogs decitabine or azacytidine, has demonstrated clinical ben
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e44c950954b0f6c38dfa2b274f54f21b
https://doi.org/10.1038/s43018-021-00249-x
https://doi.org/10.1038/s43018-021-00249-x
Autor:
Han Dai, Robert P. Law, John P. Evans, Gillian F. Watt, Chun-wa Chung, Markus A. Queisser, John D. Harling, Antonia J. Lewis, Marcus Bantscheff, João Osvaldo Rodrigues Nunes, Adam Flinders, Paul Scott-Stevens, Andrew B. Benowitz, Peter Stacey, Christopher J. Tame, Karol Buda, Diana Klimaszewska, Marcel Muelbaier, Nico Zinn
Publikováno v:
Angewandte Chemie. 133:23515-23522
Focal adhesion kinase (FAK) is a key mediator of tumour progression and metastasis. To date, clinical trials of FAK inhibitors have reported disappointing efficacy for oncology indications. We report the design and characterisation of GSK215, a poten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78bf53bda7c0c58ce1f7c8658407374a
https://doi.org/10.1002/ange.202109237
https://doi.org/10.1002/ange.202109237
Autor:
Peter Stacey, Gopal P. Sapkota, Georgina Green, Hannah Lithgow, Marcel Muelbaier, Glenn A. Burley, Andrew B. Benowitz, Ian Edward David Smith, Xiao Qing Lewell, Ryan Whatling, Markus A. Queisser, Agnieszka Konopacka, Robert P. Law, Stephen Besley, John D. Harling, Sascha Röth
Publikováno v:
SLAS Discovery. 26:885-895
Targeted protein degradation is an emerging new strategy for the modulation of intracellular protein levels with applications in chemical biology and drug discovery. One approach to enable this strategy is to redirect the ubiquitin-proteasome system
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a25d36af593c2fa67d1af3c8cf9adc5d
https://doi.org/10.1177/24725552211017517
https://doi.org/10.1177/24725552211017517
Autor:
Lykourgos-Panagiotis Zalmas, Andrew Hercules, Melanie Schneider, Ian Dunham, David Ochoa, Andrew B. Benowitz, Markus A. Queisser, Sven Ruf, Veerabahu Shanmugasundaram, Andrew R. Leach, Kris Brown, Pamela Thomas, Gerhard Hessler, Chris J Radoux, Michael M. Hann
Publikováno v:
Nature Reviews Drug Discovery. 20:789-797
Proteolysis-targeting chimeras (PROTACs) are an emerging drug modality that may offer new opportunities to circumvent some of the limitations associated with traditional small-molecule therapeutics. By analogy with the concept of the 'druggable genom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6352b333275bbdb3ccd5a0b45fd0a6a5
https://doi.org/10.1038/s41573-021-00245-x
https://doi.org/10.1038/s41573-021-00245-x
Publikováno v:
Future Medicinal Chemistry. 14:119-121
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1de76f0beb510ade808512b994a3ac21
https://doi.org/10.4155/fmc-2021-0223
https://doi.org/10.4155/fmc-2021-0223
Autor:
Andrew B. Benowitz, Juan I. Luengo, Alexandra Stowell, Ali Raoof, Daniela Ennulat, Donald J. Ogilvie, Michael T. McCabe, Monica N. Montoute, Mark Cockerill, Allan M. Jordan, Wendy S. Halsey, Melissa B. Pappalardi, Zining Wu, Ian D. Waddell, Arthur Groy, Ryan G. Kruger, Lourdes Rueda, Charity Atkins, Roger J. Butlin, Elizabeth R. Gore, Edward Long, Aidan G. Gilmartin, Dean E. McNulty
Publikováno v:
Haematologica. 106:1979-1987
Pharmacological induction of fetal hemoglobin (HbF) expression is an effective therapeutic strategy for the management of beta-hemoglobinopathies such as sickle cell disease. DNA methyltransferase (DNMT) inhibitors 5-azacytidine (5-aza) and 5-aza-2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f30b512b7a990eb0505708d154fd943
https://doi.org/10.3324/haematol.2020.248658
https://doi.org/10.3324/haematol.2020.248658
Autor:
Jenni Cryan, Don T. Fisher, Michael Reilly, Ian Edward David Smith, Anna Vossenkämper, Gillian F. Watt, Ian Churcher, John D. Harling, Allison M. Beal, Thomas T. MacDonald, Alina Mares, Phoebe Dace, Bartholomew J. Votta, Marcus Bantscheff, Jane Denyer, Paul Scott-Stevens, Afjal Hussain Miah, Andrew B. Benowitz, Aditya R. Thawani, Carol A. Capriotti, Mark David Rackham, Nico Zinn, Pamela A. Haile
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-13 (2020)
Communications Biology
Communications Biology
Proteolysis-Targeting Chimeras (PROTACs) are heterobifunctional small-molecules that can promote the rapid and selective proteasome-mediated degradation of intracellular proteins through the recruitment of E3 ligase complexes to non-native protein su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db0dc940ac613e6d44979be8bc358056
http://link.springer.com/article/10.1038/s42003-020-0868-6
http://link.springer.com/article/10.1038/s42003-020-0868-6
Publikováno v:
Expert opinion on therapeutic patents. 31(1)
PROTACs represent a novel class of heterobifunctional molecules that simultaneously bind to a target protein and to an E3 ligase complex, resulting in the transfer of ubiquitin and initiating a process ultimately causing the proteasomal degradation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55e2d3fb1a875da1dd19be6a577d647f
https://pubmed.ncbi.nlm.nih.gov/33081540
https://pubmed.ncbi.nlm.nih.gov/33081540
Autor:
Dongming Qian, Christopher J. Tame, Agnieszka Konopacka, Han Dai, Ian Churcher, Chun-wa Chung, John D. Harling, Esther Fernández, Gillian F. Watt, Markus A. Queisser, Christopher P. Tinworth, Andrew B. Benowitz, Jane Denyer, Jenni Cryan, Fan Jiang
Publikováno v:
ACS chemical biology. 15(9)
The Bcl-2 family of proteins, such as Bcl-xL and Bcl-2, play key roles in cancer cell survival. Structural studies of Bcl-xL formed the foundation for the development of the first Bcl-2 family inhibitors and FDA approved drugs. Recently
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db9fcaed9e9c6a30480d548bb31683e0
https://pubmed.ncbi.nlm.nih.gov/32697072
https://pubmed.ncbi.nlm.nih.gov/32697072