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In vitro sensitivity of granulo-monocytic progenitors as a new toxicological cell system and endpoint in the ACuteTox Project

Autor: Antonio Valeri, B. Albella, Laura Cerrato, Juan A. Bueren

Publikováno v: Toxicology and Applied Pharmacology. 238:111-119

The ACuteTox Project (part of the EU 6th Framework Programme) was started up in January 2005. The aim of this project is to develop a simple and robust in vitro strategy for prediction of human acute systemic toxicity, which could replace animal test

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cefc65b247ca808c033a23dc08cd523f
https://doi.org/10.1016/j.taap.2009.05.005

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Use of CFU-GM assay for prediction of human maximum tolerated dose of a new antitumoral drug: Yondelis™ (ET-743)

Autor: B. Albella, Glynn Faircloth, Juan A. Bueren, Susana Gómez

Publikováno v: Toxicology in Vitro. 17:671-674

Acute cytotoxic exposure causes decreases in bone marrow progenitors that precedes the neutrophil nadir. Experiments in animal models reveal a relationship between the reduction in granulocyte-macrophage progenitors (CFU-GM) and the decrease in absol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a22f189ee72c7a9b5d0e25036e98a59
https://doi.org/10.1016/s0887-2333(03)00139-5

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In Vitro Tests for Haematotoxicity: Prediction of Drug-induced Myelosuppression by the CFU-GM Assay

Autor: Maria Bayo, Silvia Casati, P Brantom, Yann Sibiri, Ralph E. Parchment, Greet Schoeters, B. Albella, C. Croera, Juan A. Bueren, Dominique Parent-Massin, Rosette Van Den Heuvel, Augusto Pessina, Laura Gribaldo

Publikováno v: Alternatives to Laboratory Animals. 30:75-79

In a prevalidation study, a Standard Operating Procedure (SOP) for human and mouse in vitro tests was developed, for evaluating the potential haematotoxicity of xenobiotics in terms of their direct, adverse effects on the myeloid colony-forming unit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a668eec8c7e8c2a031eb2e1499f1b37b
https://doi.org/10.1177/026119290203002s11

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In vitro toxicity of ET-743 and aplidine, two marine-derived antineoplastics, on human bone marrow haematopoietic progenitors

Autor: Cecilia Guzman, Glynn Faircloth, Luis Lopez-Lazaro, J. Jimeno, B. Albella, Juan A. Bueren

Publikováno v: European Journal of Cancer. 38:1395-1404

Ecteinascidine-743 (ET-743) and aplidine are two marine-derived antineoplastics currently in phase II development. With the aim of evaluating whether in vitro haematopoietic studies can predict the toxicity of these two drugs in patients, human bone

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7500fa2f540bfefb66b450289562396c
https://doi.org/10.1016/s0959-8049(01)00245-3

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Prevalidation of a model for predicting acute neutropenia by colony forming unit granulocyte/macrophage (CFU-GM) assay

Autor: Augusto Pessina, Juan A. Bueren, Dominique Parent-Massin, Laura Gribaldo, G Gagliardi, C. Croera, Silvia Casati, B. Albella, P. Foti, Ralph E. Parchment, R. Van Den Heuvel, P Brantom, Y. Sibiril

Publikováno v: Toxicology in Vitro. 15:729-740

This report describes an international prevalidation study conducted to optimise the Standard Operating Procedure (SOP) for detecting myelosuppressive agents by CFU-GM assay and to study a model for predicting (by means of this in vitro hematopoietic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f527f3077fb5b19e7f43e8bf9516bc4a
https://doi.org/10.1016/s0887-2333(01)00085-6

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In vitro hematotoxicity of Aplidine on human bone marrow and cord blood progenitor cells

Autor: Luis Lopez-Lazaro, Susana Gómez, J. Jimeno, Juan A. Bueren, Glynn Faircloth, B. Albella

Publikováno v: Toxicology in Vitro. 15:347-350

Aplidine is a cyclic depsipeptide that was isolated from a Mediterranean marine tunicate, Aplidium albicans. In experimental animals, Aplidine mediated an in vivo inhibitory effect in a number of tumor cell types. In humans, Aplidine is currently use

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dd907302e8830dfea616480db357897
https://doi.org/10.1016/s0887-2333(01)00034-0

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The value of selected in vitro and in silico methods to predict acute oral toxicity in a regulatory context: Results from the European Project ACuteTox

Publikováno v: Toxicology in Vitro
Toxicology in Vitro, Elsevier, 2013, 27 (4), pp.1357-1376. ⟨10.1016/j.tiv.2012.07.013⟩
Digital.CSIC. Repositorio Institucional del CSIC
instname
TOXICOLOGY IN VITRO
r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
r-CIPF: Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
Centro de Investigación Principe Felipe (CIPF)

ACuteTox is a project within the 6th European Framework Programme which had as one of its goals to develop, optimise and prevalidate a non-animal testing strategy for predicting human acute oral toxicity. In its last 6months, a challenging exercise w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b754f16410dccd2173de6fdd25b277f3
https://hal-univ-artois.archives-ouvertes.fr/hal-02515626

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Development of an in vitro model for the simultaneous study of the efficacy and hematotoxicity of antileukemic compounds

Autor: María Eugenia Alonso-Ferrero, Sandra Martínez, Juan A. Bueren, B. Albella, Laura Cerrato, Antonio Valeri

Publikováno v: Toxicology letters. 199(3)

Hematopoietic system displays a wide spectrum of cell populations hierarchically organized in the bone marrow. Homeostasis in this system requires equilibrium between the self-renewal of the stem cells and their capacity of differentiation. Any failu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3c9a0c5d87900d46aee1247362049ad
https://pubmed.ncbi.nlm.nih.gov/20883753

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Application of human CFU-Mk assay to predict potential thrombocytotoxity of drugs

Autor: Laura Gribaldo, I. Malerba, Dominique Parent-Massin, A. de Smedt, R. Van Den Heuvel, S. Gomez, C. Croera, Augusto Pessina, B. Albella, Y. Sibiril, Silvia Casati

Megakaryocytopoiesis gives rise to platelets by proliferation and differentiation of lineage-specific progenitors, identified in vitro as Colony Forming Unit-Megakaryocytes (CFU-Mk). The aim of this study was to refine and optimize the in vitro Stand

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75afc3c80c1144ee6393915b9c23ba51
http://hdl.handle.net/2434/54106

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Application of the CFU-GM assay to predict acute drug-induced neutropenia: an international blind trial to validate a prediction model for the maximum tolerated dose (MTD) of myelosuppressive xenobiotics

Autor: Y. Sibiril, Silvia Casati, Maria Bayo, P. Foti, Ralph E. Parchment, Greet Schoeters, C. Croera, B. Albella, Juan A. Bueren, Laura Gribaldo, P Brantom, R. Van Den Heuvel, Dominique Parent-Massin, Augusto Pessina, G Gagliardi

Publikováno v: Toxicological sciences

In a previous study of prevalidation, a standard operating procedure (SOP) for two independent in vitro tests (human and mouse) had been developed, to evaluate the potential hematotoxicity of xenobiotics from their direct and the adverse effects on g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37282da6a5292769d21bf5f6aeae9eba
https://pubmed.ncbi.nlm.nih.gov/12883091

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