Proof of the structure of the Stemodia chilensis tetracyclic diterpenoid (+)-19-acetoxystemodan-12-ol by synthesis from (+)-podocarpic acid. X‑ray structure determination of a key intermediate

Autor: Rinaldo Marini Bettolo, Doriano Lamba, Francesca Leonelli, Luisa Maria Migneco, Azzurra Mostarda, Luca De Angelis, Nicola Demitri, Francesca Ceccacci, Angela La Bella

Publikováno v: Journal of natural products
79 (2016): 1155–1159. doi:10.1021/acs.jnatprod.5b00834
info:cnr-pdr/source/autori:Leonelli F.; Mostarda A.; De Angelis L.; Lamba D.; Demitri N.; La Bella A.; Ceccacci F.; Migneco L.M.; Marini Bettolo R./titolo:Proof of the Structure of the Stemodia chilensis Tetracyclic Diterpenoid (+)-19-Acetoxystemodan-12-ol by Synthesis from (+)-Podocarpic Acid: X-ray Structure Determination of a Key Intermediate/doi:10.1021%2Facs.jnatprod.5b00834/rivista:Journal of natural products (Print)/anno:2016/pagina_da:1155/pagina_a:1159/intervallo_pagine:1155–1159/volume:79

The first synthesis of (+)-19-acetoxystemodan-12-ol (1), a stemodane diterpenoid isolated from Stemodia chilensis, is described. The structure was supported by an X-ray crystallographic analysis of intermediate (+)-9a, which confirmed the proposed st

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http://hdl.handle.net/11573/872820