Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Azzeddine Lekhal"'
Autor:
Marco Euclide Armenante, Heather Wang, Narayan Variankaval, Brittany Kassim, Xiaodong Bu, Azzeddine Lekhal, Nelo R. Rivera, Plamen Grigorov
Publikováno v:
Organic Process Research & Development. 23:2556-2561
Despite the many benefits that flow chemistry brings in the context of commercial manufacturing, a major issue for such continuous processing can be the clogging of flow equipment. In the case of v...
Publikováno v:
Organic Process Research & Development. 23:1674-1678
Verubecestat is a β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor which was previously evaluated for the treatment of Alzheimer’s disease. The synthesis of verubecestat relies ...
Autor:
Robert Hartman, Azzeddine Lekhal, Alexey A. Makarov, Xiaodong Bu, Chandan L. Barhate, Erik L. Regalado, Diego A. Lopez, Daniel W. Armstrong, William J. Morris
Publikováno v:
Journal of chromatography. A. 1539
Verubecestat is an inhibitor of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) being evaluated in clinical trials for the treatment of Alzheimer’s disease. Synthetic route development involves diastereoselective transformations with a
Autor:
Lu Chen, Carmela Molinaro, Qinghao Chen, Yanke Xu, Azzeddine Lekhal, Sarah K. Pulicare, David A. Thaisrivongs, Wenyong Chen, Steven P. Miller, Zhiguo J. Song, Lushi Tan
Publikováno v:
Organic letters. 18(22)
Verubecestat is an inhibitor of β-secretase being evaluated for the treatment of Alzheimer’s disease. The first-generation route relies on an amide coupling with a functionalized aniline, the preparation of which introduces synthetic inefficiencie
Publikováno v:
AIChE Journal. 52:2757-2766
In this study, we measure instantaneous, average, and fluctuating velocity fields at exposed surfaces for dry and wet grains in a vertical cylindrical mixer, agitated by four pitched blades. When the material is dry, the free surface of the granular
Publikováno v:
Chemical Engineering Science. 60:7091-7107
In this study, we experimentally examine flow and segregation of granular material in a cylindrical mixer geometry agitated by four 45 ∘ pitched blades, which is representative of equipment such as high-shear granulators and filter-dryers. We obser
Publikováno v:
Chemical Engineering Science. 59:1063-1077
In this study the influence of pH and ionic strength on the final metal distribution is investigated. After impregnation, catalysts are usually dried at temperatures between 50°C and 200°C. During this process, a redistribution of the metal occurs,
Autor:
Benjamin J. Glasser, Azzeddine Lekhal, Matthew A. Brown, San Kiang, Johannes Khinast, K.P. Girard
Publikováno v:
International Journal of Pharmaceutics. 270:263-277
Experiments have been carried out to study the behavior of L-threonine (needle-like) crystals during agitated drying. For an L-threonine/water system the morphology of the crystals was monitored using light microscopy and image analysis. Analysis of
Autor:
Johannes Khinast, Azzeddine Lekhal, K.P. Girard, Benjamin J. Glasser, Matthew A. Brown, S. Kiang
Publikováno v:
Powder Technology. 132:119-130
An experimental procedure was developed to study agitated drying of crystals. The procedure quantifies the impact of drying conditions (temperature, agitation speed and vacuum) on crystal properties (size and shape distribution). KCl was used as a mo
Publikováno v:
Industrial & Engineering Chemistry Research. 40:3989-3999
In this paper, a model was developed to describe the catalyst redistribution that occurs during drying of a coimpregnation catalyst. The model takes into account convective flow, catalyst and coimpregnant diffusion, adsorption on the support, and tra