Unopposed Cathepsin G, Neutrophil Elastase, and Proteinase 3 Cause Severe Lung Damage and Emphysema

Autor: Julien Wartelle, Dieter E. Jenne, G. Devouassoux, Laurette Malleret, Yves Pacheco, Azzaq Belaaouaj, Nicolas Guyot, Alexandre A. Todorov

Publikováno v: Am. J. Pathol. 184, 985-995 (2014)

Cigarette smoking is a major factor for the development of pulmonary emphysema because it induces abnormal inflammation and a protease-rich local milieu that causes connective tissue breakdown of the lungs. As a result of its capacity to degrade lung

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a4a8ffabd2921c5a1ff16cf00e922a8
https://doi.org/10.1016/j.ajpath.2014.04.015

Synthesis of PDE IVb Inhibitors. 3. Synthesis of (+)-, (−)-, and (±)-7-[3-(Cyclopentyloxy)-4-methoxyphenyl]hexahydro-3H-pyrrolizin-3-one via Reductive Domino Transformations of 3-β-Carbomethoxyethyl-Substituted Six-Membered Cyclic Nitronates

Autor: Alexey Yu, Sukhorukov, Yaroslav D, Boyko, Yulia V, Nelyubina, Stephane, Gerard, Sema L, Ioffe, Vladimir A, Tartakovsky, Laurette, Laurette Malleret, Azzaq, Belaaouaj

Publikováno v: The Journal of Organic Chemistry. 77:5465-5469

Simple three-step asymmetric and racemic syntheses of GlaxoSmithKline's highly potent PDE IVb inhibitor 1 were developed. The suggested approach is based on reductive domino transformations of 3-β-carbomethoxyethyl-substituted six-membered cyclic ni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53241292c566df4fa537c9790d531f15
https://doi.org/10.1021/jo300955n

Neutrophil Elastase Mediates Innate Host Protection against Pseudomonas aeruginosa

Autor: Azzaq Belaaouaj, Moncef Guenounou, Samuel Achilefu, Gaëtan Deslée, Tim O. Hirche, Robert E. W. Hancock, Rym Benabid, Sophie C. Gangloff, François Lebargy

Publikováno v: Scopus-Elsevier

According to the widely accepted view, neutrophil elastase (NE), a neutrophil-specific serine protease, is a major contributor to Pseudomonas aeruginosa infection-associated host tissue inflammation and damage, which in severe cases can lead to death

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a752b5f9f25dbb287fb69a747fa53751
https://doi.org/10.4049/jimmunol.181.7.4945

Neutrophil elastase-mediated increase in airway temperature during inflammation

Autor: Baroukh M. Assael, Susanne Häußler, Annika Schmidt, Jutta Hammermann, Monika Schniederjans, Gerd Döring, Rosi Bissinger, Joachim Seelig, Garrit Koller, D. Worlitzsch, Keith C. Meyer, Kenneth D. Bruce, Soeren Damkiaer, Otto Holst, Giorgio Piacentini, John J. LiPuma, Laurette Malleret, Azzaq Belaaouaj, Antonio Molinaro, Ciro D'Orazio, B Schulte-Hubbert, Martino Facchinelli

Publikováno v: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society, 2014, 13 (6), pp.623-631. ⟨10.1016/j.jcf.2014.03.004⟩

International audience; BACKGROUND: How elevated temperature is generated during airway infections represents a hitherto unresolved physiological question. We hypothesized that innate immune defence mechanisms would increase luminal airway temperatur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4034aa1d1110a946e540f0a6932bf5a
https://pubmed.ncbi.nlm.nih.gov/24713593

Neutrophil Elastase Degrades Cystic Fibrosis Transmembrane Conductance Regulator via Calpains and Disables Channel Function In Vitro and In Vivo

Autor: Emilie Saussereau, Delphine Roussel, Marc Paulais, Pierre Boulanger, Jean-Michel Sallenave, Laurette Malleret, Loïc Guillot, Saw-See Hong, Manon Ruffin, Michel Huerre, Azzaq Belaaouaj, Delphyne Descamps, Aleksander Edelman, Michel Chignard, Mathieu Le Gars, Olivier Tabary

Publikováno v: American Journal of Respiratory and Critical Care Medicine
American Journal of Respiratory and Critical Care Medicine, 2013, 187 (2), pp.170-179. ⟨10.1164/rccm.201205-0875OC⟩
American Journal of Respiratory and Critical Care Medicine, American Thoracic Society, 2013, 187 (2), pp.170-179. ⟨10.1164/rccm.201205-0875OC⟩

Comment in :The yin and yang of cystic fibrosis transmembrane conductance regulator function: implications for chronic lung disease. [Am J Respir Crit Care Med. 2013]; International audience; RATIONALE:Cystic fibrosis transmembrane conductance regula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d585eceac22851da0d815c97a7fbefd1
https://www.hal.inserm.fr/inserm-02448131