Výsledky vyhledávání - "Azza Gramoun"

Improved dynamic response assessment for intra-articular injected iron oxide nanoparticles

Autor: Kerstin Grosdemange, J Salaklang, Anthony Redjem, Bénédicte M. A. Delattre, Frank Tobalem, Lindsey A. Crowe, Alke Petri-Fink, Jean-Paul Vallée, Heinrich Hofmann, Azza Gramoun

Publikováno v: Magnetic Resonance in Medicine. 68:1544-1552

The emerging importance of nanoparticle technology, including iron oxide nanoparticles for monitoring development, progression, and treatment of inflammatory diseases such as arthritis, drives development of imaging techniques. Studies require an ima

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca88a733ede401d9abe184dd59ee2f0d
https://doi.org/10.1002/mrm.24166

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Fibronectin inhibits osteoclastogenesis while enhancing osteoclast activity via nitric oxide and interleukin-1β-mediated signaling pathways

Autor: Azza Gramoun, Natoosha Azizi, Johan N. M. Heersche, Morris F. Manolson, Jaro Sodek, Inaam A. Nakchbandi

Publikováno v: Journal of Cellular Biochemistry. 111:1020-1034

Osteoclasts are bone-resorbing cells formed by fusion of mononuclear precursors. The matrix proteins, fibronectin (FN), vitronectin (VN), and osteopontin (OPN) are implicated in joint destruction and interact with osteoclasts mainly through integrins

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feb823c7538ff5b44b8b3f7ed04a040e
https://doi.org/10.1002/jcb.22791

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Bone matrix proteins and extracellular acidification: Potential co-regulators of osteoclast morphology

Autor: Ori D. Rotstein, Morris F. Manolson, Tetsuya Goto, Azza Gramoun, Tommy Nordström, Johan N. M. Heersche, Sergio Grinstein

Publikováno v: Journal of Cellular Biochemistry. 111:350-361

Osteoclasts are signaled by the bone matrix proteins fibronectin (FN), vitronectin (VN), and osteopontin (OPN) via integrins. To perform their resorptive function, osteoclasts cycle between compact (polarized), spread (non-resorbing) and migratory mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec116139fa8f05eb178a15324c9941ca
https://doi.org/10.1002/jcb.22705

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Increased expression of activating factors in large osteoclasts could explain their excessive activity in osteolytic diseases

Autor: Johan N. M. Heersche, Morris F. Manolson, Divya Chandra, Diana P. Trebec, Azza Gramoun, Keying Li

Publikováno v: Journal of Cellular Biochemistry. 101:205-220

Large osteoclasts (>or=10 nuclei) predominate at sites of pathological bone resorption. We hypothesized this was related to increased resorptive activity of large osteoclasts and have demonstrated previously that larger osteoclasts are 8-fold more li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab4f9a1e060a15d7077eb1d08a56a6f4
https://doi.org/10.1002/jcb.21171

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Effects of Vitaxin®, a novel therapeutic in trial for metastatic bone tumors, on osteoclast functions in vitro

Autor: Jill D. Bashutski, Morris F. Manolson, S. Jeffrey Dixon, Stephen M. Sims, Johan N. M. Heersche, Seema Shorey, Azza Gramoun

Publikováno v: Physiology and Pharmacology Publications

The integrin alphavbeta3 mediates cell-matrix interactions. Vitaxin(R), a humanized monoclonal antibody that blocks human and rabbit alphavbeta3 integrins, is in clinical trials for metastatic melanoma and prostate cancer. alphavbeta3 is the predomin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9102594b2d3e893fdfd4d92a590e0012
https://doi.org/10.1002/jcb.21296

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Amino-polyvinyl Alcohol Coated Superparamagnetic Iron Oxide Nanoparticles are Suitable for Monitoring of Human Mesenchymal Stromal Cells In Vivo

Autor: Peter Guttmann, Frank Schulze, Paul Zaslansky, Anke Dienelt, Lindsey A. Crowe, Georg N. Duda, Janosch Schoon, Jean-Paul Vallée, Azza Gramoun, Heinrich Hofmann, Sven Geissler, Lionel Maurizi, Andrea Ode, Katja Henzler

Publikováno v: Small, Vol. 10, No 21 (2014) pp. 4340-4351
Small
Small, Wiley-VCH Verlag, 2014, pp.n/a-n/a. ⟨10.1002/smll.201400707⟩

Mesenchymal stromal cells (MSCs) are promising candidates in regenerative cell-therapies. However, optimizing their number and route of delivery remains a critical issue, which can be addressed by monitoring the MSCs' bio-distribution in vivo using s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a57a26d9d1feff30a6ce774a6263b685
https://doi.org/10.1002/smll.201400707

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A fast and reproducible method to quantify magnetic nanoparticle biodistribution

Autor: Usawadee Sakulkhu, Heinrich Hofmann, Azza Gramoun, Lionel Maurizi, Jean-Paul Vallée

Publikováno v: The Analyst
The Analyst, Vol. 139, No 5 (2014) pp. 1184-1191
Analyst
Analyst, Royal Society of Chemistry, 2014, 139 (5), pp.1184-1191. ⟨10.1039/C3AN02153J⟩

International audience; The quantification of nanoparticles, particularly superparamagnetic iron oxide nanoparticles (SPION), both in vitro and in vivo has become highly important in recent years. Some methods, such as induced coupled plasma spectros

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf4453e5f3f0ebcc8e3791368230cfeb
https://pubmed.ncbi.nlm.nih.gov/24448415

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Monitoring the effects of dexamethasone treatment by MRI using in vivo iron oxide nanoparticle-labeled macrophages

Autor: Heinrich Hofmann, Wolfgang Wirth, Kerstin Grosdemange, Lindsey A. Crowe, Lionel Maurizi, Marije I. Koenders, Frank Tobalem, Géraldine Coullerez, Azza Gramoun, Felix Eckstein, Jean-Paul Vallée, Wim B. van den Berg

Publikováno v: Arthritis Research and Therapy
Arthritis Research and Therapy, BioMed Central, 2014, 16 (3), pp.R131. ⟨10.1186/ar4588⟩
Arthritis Research & Therapy, Vol. 16, No 3 (2014) P. R131
Arthritis Research & Therapy
Arthritis Research & Therapy, 16, 3, pp. R131
Arthritis Research & Therapy, 16, R131

Contains fulltext : 137472.pdf (Publisher’s version ) (Open Access) INTRODUCTION: Rheumatoid arthritis (RA) is a chronic disease causing recurring inflammatory joint attacks. These attacks are characterized by macrophage infiltration contributing t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33f8c921c85d460ce7f817807d0d80b1
https://hal.archives-ouvertes.fr/hal-02163410/document

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Nitric oxide enhances osteoclastogenesis possibly by mediating cell fusion

Autor: Morris F. Manolson, Dorrin Nilforoushan, Michael Glogauer, Azza Gramoun

Publikováno v: Nitric oxide : biology and chemistry. 21(1)

Osteoclasts are multinucleated bone resorbing cells which form by fusion of pre-osteoclasts. Here, we investigate how nitric oxide (NO) affects osteoclastogenesis. Time lapse photomicrography, using the fluorescent NO indicator dye, 4,5-diaminofluore

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6abd77d743d1675003ec6be736451d42
https://pubmed.ncbi.nlm.nih.gov/19389479

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SAT0053 Advantages of non-invasive imaging techniques in monitoring antigen induced arthritis rat model

Autor: Marije I. Koenders, Kerstin Grosdemange, Lindsey A. Crowe, Jean-Paul Vallée, Bénédicte M. A. Delattre, Azza Gramoun, Frank Tobalem, D. Tchernin, W.B. van den Berg, Xavier Montet

Publikováno v: Annals of the Rheumatic Diseases. 71:488.3-488

Background Disease assessment using magnetic resonance imaging (MRI) in small animal models of rheumatoid arthritis (RA) is not a commonly used method to date. Inflammation and erosion histological scoring remain the gold standard and more recently �

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3ee1e01cd92bda8628559101f00c679a
https://doi.org/10.1136/annrheumdis-2012-eular.3001

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