Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Azusa OKANIWA"'
Autor:
Azusa Okaniwa, Dai Watanabe, Makoto Ishigami, Hiroyasu Mizuguchi, Toshiya Ishii, Hisako Hori, Toshifumi Oyamada, Toru Hoshiya, Tsutomu Ishikawa
Publikováno v:
The Journal of Toxicological Sciences. 33:241-244
In order to prepare background data for toxicity studies, serum alkaline phosphatase activity in a total of 5,242 male and female beagle dogs was surveyed for the sequence of changes in activity through aging. About 95% of the beagle dogs surveyed we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b06a29fc6a04390764036604566b811a
https://doi.org/10.2131/jts.33.241
https://doi.org/10.2131/jts.33.241
Autor:
Yoshikazu Nagashima, Dai Watanabe, Yuko Yamaguchi, Hiroyasu Yoshikawa, Hiromi Nakara, Azusa Okaniwa, Keisuke Akagi, Toru Hoshiya
Publikováno v:
Journal of Toxicologic Pathology. 17:187-195
Beagle dogs intravenously treated with alloxan monohydrate at 50 mg/kg and kept for 14 months were subjected to clinicopathological and histopathological examinations in order to characterize the development of diabetic changes. The beagle model of d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4c66d87e81ea5b67cc12b72396ad828
https://doi.org/10.1293/tox.17.187
https://doi.org/10.1293/tox.17.187
Autor:
Azusa Okaniwa, Tetsuya Matsuoka, Dai Watanabe, Yuko Yamaguchi, Toru Hoshiya, Takashi Yoshikawa, Toshiya Ishii, Hitoshi Saito, Yoshikazu Nagashima, Kazuhisa Hatayama
Publikováno v:
Journal of Toxicologic Pathology. 15:49-59
The present study was designed to clarify the pathologic features of hyperphosphatasemic conditions in association with drug metabolizing enzyme (DME) induction and cholestatic condition in dogs. Two (2) model compounds were selected; α-naphthylisot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0951486fcbbcfae10c5a50e5969db57
https://doi.org/10.1293/tox.15.49
https://doi.org/10.1293/tox.15.49
Autor:
Tetsuya Matsuoka, Toru Hoshiya, Yasuhiro Miki, Toshiya Ishii, Noriyuki Nomura, Hiroyasu Mizuguchi, Dai Watanabe, Yoshikazu Nagashima, Kousuke Horiguchi, Azusa Okaniwa
Publikováno v:
The Journal of Toxicological Sciences. 26:103-109
Occurrence of characteristic transient changes in WBC counts and fibrinogen values in beagle dogs subjected to single-dose toxicity studies was pointed out in the previous survey (Hoshiya et al., 2001). These changes were thought to belong to the cat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::379e9a74c3666c32e42ede832df155e3
https://doi.org/10.2131/jts.26.103
https://doi.org/10.2131/jts.26.103
Autor:
Hiroshi Kuse, Takaaki Yamamura, Hirofumi Yuasa, Kinji Kobayashi, Toshihide Inui, Atsushi Koguchi, Azusa Okaniwa, Toshihisa Fujiwara, Yoshiaki Kawai
Publikováno v:
Journal of Toxicologic Pathology. 7:81-86
Scanning electron microscopic observation of the organ of Corti was conducted in kanamycin (KM)-treated beagle dogs, which were subjected to time lapse recording of auditory brainstem response (ABR). KM was administered subcutaneously 5 times per wee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c99219c5a358268548054d8243214c82
https://doi.org/10.1293/tox.7.81
https://doi.org/10.1293/tox.7.81
Autor:
Kazuyuki Kitamura, Akira Yasoshima, Hiroyasu Yoshikawa, Hitoshi Iwasaki, Takashi Yoshikawa, Azusa Okaniwa
Publikováno v:
Experimental and Molecular Pathology. 57:153-166
Female Swiss mice were treated for 24 weeks, with 3-hydroxy-4-pyrone (Py) added to their powdered diet at 0.5% (wt/wt), and the effects of this agent on the liver were examined. Serum transaminases (especially GPT) rose continuously, while the GOT/GP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a02b2a46d4c00132960eeda2fb7c254
https://doi.org/10.1016/0014-4800(92)90007-x
https://doi.org/10.1016/0014-4800(92)90007-x
Publikováno v:
Journal of Toxicologic Pathology. 13:127-129
A 9-month-old male beagle suddenly died without any clinical signs. Histopathologically, he showed acute circulatory insufficiency due to diffuse degenerative changes of blood vessels and exudation from arterioles and myocardial contraction band necr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4950772f2262baa31dd27ba67824c157
https://doi.org/10.1293/tox.13.127
https://doi.org/10.1293/tox.13.127
Autor:
Azusa Okaniwa, Akihiro Kojima
Publikováno v:
Journal of Veterinary Medical Science. 53:1059-1063
Seventeen field isolates of sialodacryoadenitis (SDA) virus had been isolated from the lung of rats with clinical SDA during epizootics of SDA from 1976 to 1978 in the research laboratory. Based on their neutralization patterns against antisera to st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::717b54e54d23553d8aee4adcbf0fc23a
https://doi.org/10.1292/jvms.53.1059
https://doi.org/10.1292/jvms.53.1059
Autor:
Hirofumi Yuasa, Toshihide Inui, Tadao Serikawa, Takaaki Yamamura, Junzo Yamada, Yoshiaki Kawai, Azusa Okaniwa
Publikováno v:
Brain Research. 517:123-133
The spontaneously epileptic rat (SER), a mutant homozygous for both zitter and tremor genes, exhibits absence-like seizures and tonic convulsions without external stimulation from 7 to 8 weeks of age. Histopathological studies of the central nervous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b02c46b901c44418dd0c40e56499195
https://doi.org/10.1016/0006-8993(90)91017-b
https://doi.org/10.1016/0006-8993(90)91017-b
Publikováno v:
Laboratory Animals. 24:131-136
Spontaneously epileptic rats (SER) are homozygous for two mutations, zitter ( zi) and tremor ( tm), and spontaneously exhibit both absence-like seizure and tonic convulsion. In addition, wild jumping or running episodes sometimes appear without any p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0b42429dc943dcee977152596f96ad0
https://doi.org/10.1258/002367790780890194
https://doi.org/10.1258/002367790780890194