Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Azumi, Ueyama"'
Autor:
Yoshinori Hayashi, Azumi Ueyama, Soichiro Funaki, Koichi Jinushi, Naoko Higuchi, Hitomi Morihara, Michinari Hirata, Yoji Nagira, Takuro Saito, Atsunari Kawashima, Kota Iwahori, Yasushi Shintani, Hisashi Wada
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-12 (2024)
Abstract Background CCR8-expressing regulatory T cells (Tregs) are selectively localized within tumors and have gained attention as potent suppressors of anti-tumor immunity. This study focused on CCR8+ Tregs and their interaction with CD8+ T cells i
Externí odkaz:
https://doaj.org/article/563e65b4308c413c9805ac940ecc8099
Autor:
Atsushi Kumanogoh, Hisashi Wada, Yoshito Takeda, Mari Tone, Yasushi Shintani, Kota Iwahori, Michinari Hirata, Azumi Ueyama, Akiyoshi Tani, Jun-Ichi Haruta
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 4 (2024)
Background Cancer immunotherapy including immune checkpoint inhibitors is only effective for a limited population of patients with cancer. Therefore, the development of novel cancer immunotherapy is anticipated. In preliminary studies, we demonstrate
Externí odkaz:
https://doaj.org/article/c59908baeae14bb5b96141a34ab1d949
Autor:
Hitomi Morihara, Tomomi Yamada, Yumi Tona, Marina Akasaka, Hirohisa Okuyama, Natsumi Chatani, Satomi Shinonome, Azumi Ueyama, Kenji Kuwabara, Yasushi Fujio
Publikováno v:
PLoS ONE, Vol 19, Iss 8, p e0305984 (2024)
Inhibiting the cytotoxic T-lymphocyte-associated protein-4 (CTLA-4)-mediated immune checkpoint system using an anti-CTLA-4 antibody (Ab) can suppress the growth of various cancers, but the detailed mechanisms are unclear. In this study, we establishe
Externí odkaz:
https://doaj.org/article/b1f8393907fc4471bd1ddd6927a36cd1
Autor:
Miya Haruna, Azumi Ueyama, Yoko Yamamoto, Michinari Hirata, Kumiko Goto, Hiroshi Yoshida, Naoko Higuchi, Tetsuya Yoshida, Yujiro Kidani, Yamami Nakamura, Morio Nagira, Atsunari Kawashima, Kota Iwahori, Yasushi Shintani, Naganari Ohkura, Hisashi Wada
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Regulatory T cells (Tregs) suppress the host immune response and maintain immune homeostasis. Tregs also promote cancer progression and are involved in resistance to immune checkpoint inhibitor treatments. Recent studies identified selective
Externí odkaz:
https://doaj.org/article/51a74d2b5acc4db8a5531e85252d6b2f
Autor:
Yohei Nose, Takuro Saito, Kei Yamamoto, Kotaro Yamashita, Koji Tanaka, Kazuyoshi Yamamoto, Tomoki Makino, Tsuyoshi Takahashi, Atsunari Kawashima, Miya Haruna, Michinari Hirata, Azumi Ueyama, Kota Iwahori, Taroh Satoh, Yukinori Kurokawa, Hidetoshi Eguchi, Yuichiro Doki, Hisashi Wada
Publikováno v:
Cancer Immunology, Immunotherapy. 72:169-181
Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment. Since clinical benefits are limited to a subset of patients, we aimed to identify peripheral blood biomarkers that predict the efficacy of the anti-programmed cell death protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c97c421a3ca70079fa191bb62ecf3693
https://doi.org/10.1007/s00262-022-03240-2
https://doi.org/10.1007/s00262-022-03240-2
Autor:
Hitomi, Kajikawa, Michinari, Hirata, Miya, Haruna, Azumi, Ueyama, Katsutoshi, Hirose, Atsunari, Kawashima, Kota, Iwahori, Kazuhide, Matsunaga, Satoru, Toyosawa, Narikazu, Uzawa, Hisashi, Wada
Publikováno v:
Anticancer research. 42(5)
Tumor immunity in the tumor microenvironment is activated in patients with feasible clinical responses to immune checkpoint inhibitors. The immunological profile of tumor-infiltrating lymphocytes (TILs) obtained from patients with oral squamous cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::420bc891c2424eaf52fed571f1c3b825
https://pubmed.ncbi.nlm.nih.gov/35489733
https://pubmed.ncbi.nlm.nih.gov/35489733
Autor:
Yujiro Kidani, Wataru Nogami, Yoshiaki Yasumizu, Atsunari Kawashima, Atsushi Tanaka, Yudai Sonoda, Yumi Tona, Kunitaka Nashiki, Reimi Matsumoto, Masaki Hagiwara, Motonao Osaki, Keiji Dohi, Takayuki Kanazawa, Azumi Ueyama, Mai Yoshikawa, Tetsuya Yoshida, Mitsunobu Matsumoto, Kanji Hojo, Satomi Shinonome, Hiroshi Yoshida, Michinari Hirata, Miya Haruna, Yamami Nakamura, Daisuke Motooka, Daisuke Okuzaki, Yasuko Sugiyama, Makoto Kinoshita, Tatsusada Okuno, Taigo Kato, Koji Hatano, Motohide Uemura, Ryoichi Imamura, Kazunori Yokoi, Atsushi Tanemura, Yasushi Shintani, Tadashi Kimura, Norio Nonomura, Hisashi Wada, Masaki Mori, Yuichiro Doki, Naganari Ohkura, Shimon Sakaguchi
Publikováno v:
Proceedings of the National Academy of Sciences. 119
SignificanceImmunosuppressive Foxp3-expressing regulatory T cells (Tregs) in tumor tissues are assumed to be clonally expanding via recognizing tumor-associated antigens. By single-cell RNA sequencing, we have searched for the molecules that are spec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d4710bc2308f5adf752d06c10e3ca4b
https://doi.org/10.1073/pnas.2114282119
https://doi.org/10.1073/pnas.2114282119
Autor:
Miya Haruna, Azumi Ueyama, Yoko Yamamoto, Michinari Hirata, Kumiko Goto, Hiroshi Yoshida, Naoko Higuchi, Tetsuya Yoshida, Yujiro Kidani, Yamami Nakamura, Morio Nagira, Atsunari Kawashima, Kota Iwahori, Yasushi Shintani, Naganari Ohkura, Hisashi Wada
Publikováno v:
Scientific reports. 12(1)
Regulatory T cells (Tregs) suppress the host immune response and maintain immune homeostasis. Tregs also promote cancer progression and are involved in resistance to immune checkpoint inhibitor treatments. Recent studies identified selective CCR8 exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad897718e284fa4cb0312185d9a6babd
https://pubmed.ncbi.nlm.nih.gov/35354899
https://pubmed.ncbi.nlm.nih.gov/35354899
Autor:
Masahide Odan, Shiho Yamamoto, Takayo Haruna, Shiro Kida, Yoshikazu Sasaki, Ayahisa Watanabe, Masaya Shimizu, Takayuki Okuno, Azumi Ueyama
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:3549-3553
The retinoic acid receptor-related orphan receptor-gamma-t (RORγt) is the master transcription factor responsible for regulating the development and function of T-helper 17 (Th17) cells, which are related to the pathology of several autoimmune disor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f021050106ded152726daddddc2fe5f
https://doi.org/10.1016/j.bmcl.2018.09.032
https://doi.org/10.1016/j.bmcl.2018.09.032
Autor:
Wataru Nogami, Morio Nagira, Azumi Ueyama, Naganari Ohkura, Yoji Nagira, Ryohei Nagai, Mai Yoshikawa, Michinari Hirata, Hisashi Wada
Publikováno v:
Journal for ImmunoTherapy of Cancer. 9:A914-A914
BackgroundRegulatory T cells (Tregs) are suppressive immune cells required for the maintenance of immune homeostasis, but tumor-infiltrating Tregs are known to suppress the antitumor immune system and promote tumor progression. Therefore, selective r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5666d15028d3c946d7b3b1ec0c734de9
https://doi.org/10.1136/jitc-2021-sitc2021.873
https://doi.org/10.1136/jitc-2021-sitc2021.873