Zobrazeno 1 - 10 of 19 pro vyhledávání: '"Azuma Yamaguchi"'
1
Studies on new antiulcer agents. I. Synthesis and antisecretory activity of pyridazine derivatives
Autor: Hiroshi Shimamura, Youichi Nobuhara, Azuma Yamaguchi, Toshihiro Yamada, Masahiko Ohki, Kazuo Yoshihara
Publikováno v: Chemical and Pharmaceutical Bulletin. 29:3433-3439
The pyridine ring of 2-phenyl-2-(2-pyridyl) thioacetamide (Ia), the lead compound for the present study, was replaced by a pyridazine ring in the hope of obtaining more potent and less toxic drugs with long-lasting action, and a series of 2-phenyl-2-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef62afdcb85890d17d663b5af1040d23
https://doi.org/10.1248/cpb.29.3433
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2
Pyridazinones. 2. Synthesis and antisecretory and antiulcer activities of thiourea and 2-cyanoguanidine derivatives
Autor: Kazuo Yoshihara, Toshihiro Yamada, Masahiko Ohki, Youichi Nobuhara, Azuma Yamaguchi, Hiroshi Shimamura, Yoshitsugu Tsukamoto
Publikováno v: Journal of Medicinal Chemistry. 26:373-381
In an effort to develop new types of antiulcer agents, we synthesized a series of novel 2-[omega-(thioureido)alkyl]- and 2-[omega-(cyanoguanidino)alkyl]-3(2H)-pyridazinone derivatives. All target compounds were evaluated for gastric antisecretory act
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65c3b4fce24652f04833a2c93e334629
https://doi.org/10.1021/jm00357a012
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3
Pituitary-adrenocortical stimulation and anti-inflammatory actions of 4-ethoxy-2-methyl-5-morpholino-3(2H)-pyridazinone (M73101)
Autor: Makoto Sato, Azuma Yamaguchi, Mikiko Kataoka
Publikováno v: Journal of Pharmacobio-Dynamics. 4:649-655
We investigated the mechanism of the elevation of serum corticosterone level by 4-ethoxy-2-methyl-5-morpholino-3(2H)-pyridazinone (M73101) and its participation in the anti-inflammatory action. M73101 when given to rats intraperitoneally at doses of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b8697f41bf9717a584fa5e00df0ad39
https://doi.org/10.1248/bpb1978.4.649
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4
Systemic responses to adjuvant arthritic rats and effects of anti-inflammatory drugs
Autor: Azuma Yamaguchi
Publikováno v: Folia Pharmacologica Japonica. 73:379-399
ラットadjuvant関節炎モデルを用いて抗炎症効果を評価する際に，その指標として局所の炎症反応と共に，炎症の進展に伴って現われる種々の全身性反応を用いる意義について検討し，次
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fd5034b8fd63f560ecd5a7a5eb1f0222
https://doi.org/10.1254/fpj.73.379
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6
Studies on the infusion speed and acute toxicity of amino acid solutions in rats
Autor: Azuma Yamaguchi, Tamotsu Fukuda, Hisayuki Tanizawa, Mikiko Kataoka
Publikováno v: Folia Pharmacologica Japonica. 74:589-595
Relationships between the infusion speed and lethal dose of several amino acid solutions of various concentrations were studied in male Sprague Dawley rats. When the amino acid solutions were continuously infused at various speeds, a functional relat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b4c0102b87d58c775d58d0fd369f3c19
https://doi.org/10.1254/fpj.74.589
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