Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Azuma Kimura"'
Autor:
Tomoya Mori, Toshiro Takase, Kuan-Chun Lan, Junko Yamane, Cantas Alev, Azuma Kimura, Kenji Osafune, Jun K. Yamashita, Tatsuya Akutsu, Hiroaki Kitano, Wataru Fujibuchi
Publikováno v:
BMC Bioinformatics, Vol 24, Iss 1, Pp 1-27 (2023)
Abstract Background Bioinformatics capability to analyze spatio–temporal dynamics of gene expression is essential in understanding animal development. Animal cells are spatially organized as functional tissues where cellular gene expression data co
Externí odkaz:
https://doaj.org/article/c7beb770fa2146338f81cea694edbec4
Autor:
Ryo Ito, Azuma Kimura, Yurie Hirose, Yu Hatano, Atsushi Mima, Shin-Ichi Mae, Yamato Keidai, Toshihiro Nakamura, Junji Fujikura, Yohei Nishi, Akira Ohta, Taro Toyoda, Nobuya Inagaki, Kenji Osafune
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract For pluripotent stem cell (PSC)-based regenerative therapy against diabetes, the differentiation efficiency to pancreatic lineage cells needs to be improved based on the mechanistic understanding of pancreatic differentiation. Here, we aimed
Externí odkaz:
https://doaj.org/article/df2cb19d80214e9ca8bdf82af4846cfd
Publikováno v:
Stem Cell Research, Vol 24, Iss C, Pp 61-68 (2017)
While pancreatic islet transplantation achieves insulin independence in type 1 diabetes (T1D) patients, its widespread application is limited by donor tissue scarcity. Pancreatic progenitor cells (PPCs) give rise to all cell types in the pancreas dur
Externí odkaz:
https://doaj.org/article/a43bb141675744d4b06a3b0ac06b8ef1
Autor:
Taro Toyoda, Azuma Kimura, Hiromi Tanaka, Tomonaga Ameku, Atsushi Mima, Yurie Hirose, Masahiro Nakamura, Akira Watanabe, Kenji Osafune
Publikováno v:
Stem Cell Reports, Vol 9, Iss 2, Pp 419-428 (2017)
Summary: There has been increasing success with the generation of pancreatic cells from human induced pluripotent stem cells (hiPSCs); however, the molecular mechanisms of the differentiation remain elusive. The purpose of this study was to reveal no
Externí odkaz:
https://doaj.org/article/874b239179154c9fb6024d4fa134e059
Publikováno v:
Stem Cell Research, Vol 15, Iss 1, Pp 75-87 (2015)
Due to the limitation of current pharmacological therapeutic strategies, stem cell therapies have emerged as a viable option for treating many incurable neurological disorders. Specifically, human pluripotent stem cell (hPSC)-derived neural progenito
Externí odkaz:
https://doaj.org/article/c958d32df3d84fe19cc3b5a4b70232e2
Autor:
Yuta Tsujisaka, Takeshi Hatani, Chikako Okubo, Ryo Ito, Azuma Kimura, Megumi Narita, Kazuhisa Chonabayashi, Shunsuke Funakoshi, Antonio Lucena-Cacace, Taro Toyoda, Kenji Osafune, Takeshi Kimura, Hirohide Saito, Yoshinori Yoshida
Publikováno v:
Stem Cell Reports. 17:1772-1785
For regenerative cell therapies using pluripotent stem cell (PSC)-derived cells, large quantities of purified cells are required. Magnetic-activated cell sorting (MACS) is a powerful approach to collect target antigen-positive cells; however, it rema
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d878b522808a83c2f0cb1ff13713631e
https://doi.org/10.1016/j.stemcr.2022.05.003
https://doi.org/10.1016/j.stemcr.2022.05.003
Publikováno v:
Proceedings for Annual Meeting of The Japanese Pharmacological Society. 96:YIA02-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::363966da975b3d7a32d90df953591677
https://doi.org/10.1254/jpssuppl.96.0_yia02-1
https://doi.org/10.1254/jpssuppl.96.0_yia02-1
Publikováno v:
Journal of visualized experiments : JoVE. (145)
Human pluripotent stem cell (hPSC)-derived pancreatic cells are a promising cell source for regenerative medicine and a platform to study human developmental processes. Stepwise directed differentiation that recapitulates developmental processes is o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6c6f08c09eecf71f5ba63767a641a102
https://pubmed.ncbi.nlm.nih.gov/30985740
https://pubmed.ncbi.nlm.nih.gov/30985740
Publikováno v:
Journal of Visualized Experiments.
Human pluripotent stem cell (hPSC)-derived pancreatic cells are a promising cell source for regenerative medicine and a platform to study human developmental processes. Stepwise directed differentiation that recapitulates developmental processes is o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::882d507211905332e7b4014d794653e6
https://doi.org/10.3791/57641
https://doi.org/10.3791/57641
Publikováno v:
Cell Chemical Biology. 27:1561-1572.e7
The proliferation of human pancreatic progenitor cells (PPCs) is critical for developing cell therapies for diabetes. Here, using transcriptome analysis combined with small interfering RNA (siRNA) screening, we revealed that WNT7B is a downstream gro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f689c17e0c7c195d0662db3ae16dfe0
https://doi.org/10.1016/j.chembiol.2020.08.018
https://doi.org/10.1016/j.chembiol.2020.08.018