Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Azriel Schmidt"'
Autor:
Azriel Schmidt, Michael Chisamore, Carlo J. Gambone, Gregory Michael Dillon, Stephen E. Alves, Matthew Baran, Sean Riley, Michael A. Gentile, Osvaldo A. Flores, Hilary A. Wilkinson
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 163:88-97
The androgen receptor (AR) is a member of the nuclear hormone receptor super family of transcription factors. Androgens play an essential role in the development, growth, and maintenance of male sex organs, as well as the musculoskeletal and central
Autor:
William J. Ray, Chang Bai, Stephen E. Alves, Tara E. Cusick, Brenda L Pennypacker, Evan E. Opas, Michael J. Chisamore, Carlo J. Gambone, Damien Ferraro, David J. Bettoun, Azriel Schmidt, Hilary A. Wilkinson, Angela Scafonas, Michael A. Gentile, Osvaldo A. Flores, Paul Hodor, Meissner Robert S, James J. Perkins
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 143:29-39
Prostate cancer (PCa) initially responds to inhibition of androgen receptor (AR) signaling, but inevitably progresses to hormone ablation-resistant disease. Much effort is focused on optimizing this androgen deprivation strategy by improving hormone
Autor:
Pascale V. Nantermet, Thomayant Prueksaritanont, William J. Ray, James J. Perkins, Chih-Tai Leu, Fang Chen, Azriel Schmidt, Mark E. Duggan, Viera Kasparcova, Sharon Adamski, Donald B. Kimmel, Leonard P. Freedman, SuJane Rutledge, T. Cusick, Brenda L Pennypacker, George D. Hartman, Jiabing Wang, P. Masarachia, Meissner Robert S, Shun-ichi Harada, Paul Hodor, Robert L. Vogel, Chang Bai, Hai-Zhuan Zhang, Sheila McElwee-Witmer, Helen J. Mitchell, Michael A. Gentile, Evan E. Opas, Angela Scafonas, Yuntae Kim
Publikováno v:
Journal of Biological Chemistry. 285:17054-17064
Selective androgen receptor modulators (SARMs) are androgen receptor (AR) ligands that induce anabolism while having reduced effects in reproductive tissues. In various experimental contexts SARMs fully activate, partially activate, or even antagoniz
Publikováno v:
Journal of Bone and Mineral Research. 8:403-414
Recent findings suggest that the vitronectin receptor, a member of the integrin family, plays an important role in the attachment of osteoclasts to bone matrix. We report here the localization by in situ hybridization of the mRNA for the alpha and be
Autor:
Soumya P. Sahoo, Donald B. Kimmel, P. Masarachia, Pascale V. Nantermet, Meissner Robert S, Fang Chen, William J. Ray, Dwight A. Towler, Shun Ichi Harada, Chang Bai, Angela Scafonas, Mark E. Duggan, Brenda L Pennypacker, Su Jane Rutledge, Azriel Schmidt, Gideon A. Rodan, Sheila McElwee-Witmer, Robert L. Vogel, Michael A. Gentile, George D. Hartman, Yuntae Kim
Publikováno v:
Journal of Biological Chemistry. 284:36367-36376
Androgen replacement therapy is a promising strategy for the treatment of frailty; however, androgens pose risks for unwanted effects including virilization and hypertrophy of reproductive organs. Selective Androgen Receptor Modulators (SARMs) retain
Autor:
Gideon A. Rodan, Dwight A. Towler, Azriel Schmidt, Elizabeth T. Birzin, Pascale V. Nantermet, Evan E. Opas, James M. Schaeffer, Hilary A. Wilkinson, Lawrence F. Colwell, Robert R. Wilkening, Angela Scafonas
Publikováno v:
Maturitas. 64:46-51
Objective To test the role of ERβ in the control of estrogen-dependent thermoregulation in rats. Methods Test the ability of an ERβ-selective ligand to suppress the elevation in basal rat tail skin temperature (TST) caused by ovariectomy (OVX). Res
Autor:
Hai Z. Zhang, Sheila McElwee-Witmer, Azriel Schmidt, Mark E. Duggan, William J. Ray, Chih-Tai Leu, Chang Bai, Pascale V. Nantermet, Donald B. Kimmel, William P. Dankulich, Thomayant Prueksaritanont, Fang Chen, Robert L. Vogel, Michael A. Gentile, Meissner Robert S, George D. Hartman, Helen J. Mitchell
Publikováno v:
Journal of Medicinal Chemistry. 52:4578-4581
A novel series of 16-substituted-4-azasteroids has been identified as potential tissue-selective androgen receptor modulators. These ligands display potent hAR binding and agonist activity, low virilizing potential, and good pharmacokinetic profiles
Publikováno v:
Maturitas. 53:210-216
Objective Estrogen is the most effective treatment for preventing the vasomotor symptoms in women. The ability of estrogen to control tail skin temperature (TST) in rats is used as an animal model for the studies of estrogens on menopausal hot flushe
Autor:
Azriel Schmidt, Chang Bai, Angela Scafonas, Carlo J. Gambone, Su Jane Rutledge, Leonard P. Freedman, Sheila McElwee-Witmer, Robert L. Vogel, Paul Hodor, Oliver Chen, David J. Bettoun
Publikováno v:
Journal of Biological Chemistry. 280:38898-38901
Signaling by androgens and interferons (IFN) plays an important role in prostate cancer initiation and progression. Using microarray analysis, we describe here a functional cross-talk between dihydrotestosterone and interferon signaling. Glutathione
Autor:
Azriel Schmidt, John E. Fisher, Alfred A. Reszka, Leonard P. Freedman, Shun-ichi Harada, Marina Mojena, Consuelo Tudela Moreno, Elizabeth T. Birzin, Kristin Knecht, Hilary A. Wilkinson, Fang Chen
Publikováno v:
Endocrinology. 146:4568-4576
Dehydroepiandrosterone (DHEA) exhibits peak adrenal secretion in the fetus at term and around age 30 yr in the adult. Levels then progressively decline, which is associated with decreased levels of testosterone, dihydrotestosterone, and estrogen in p