Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Azra Blazevic"'
Autor:
Richard F. Silver, Mei Xia, Chad E. Storer, Jessica R. Jarvela, Michelle C. Moyer, Azra Blazevic, David A. Stoeckel, Erin K. Rakey, Jan M. Tennant, Johannes B. Goll, Richard D. Head, Daniel F. Hoft
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Tuberculosis remains an international health threat partly because of limited protection from pulmonary tuberculosis provided by standard intradermal vaccination with Bacillus of Calmette and Guérin (BCG); this may reflect the inability of
Externí odkaz:
https://doaj.org/article/f8f84a0fa65143f59a7acea80e7cee39
Autor:
Zachary K. Sagawa, Cristina Goman, Aude Frevol, Azra Blazevic, Janice Tennant, Bridget Fisher, Tracey Day, Stephen Jackson, Franck Lemiale, Leon Toussaint, Irene Kalisz, Joe Jiang, Lisa Ondrejcek, Raodoh Mohamath, Julie Vergara, Alan Lew, Anna Marie Beckmann, Corey Casper, Daniel F. Hoft, Christopher B. Fox
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Here the authors present results from a randomized, double-blinded Phase 1 clinical trial, testing a thermostable presentation of a clinical-stage adjuvanted subunit tuberculosis vaccine candidate. The vaccine candidate is safe and well tolerated, an
Externí odkaz:
https://doaj.org/article/0416e608bded4e49acce0289f6385372
Autor:
Christopher S. Eickhoff, Krystal A. Meza, Frances E. Terry, Chase G. Colbert, Azra Blazevic, Andres H. Gutiérrez, E. Taylor Stone, James D. Brien, Amelia K. Pinto, Hana M. El Sahly, Mark J. Mulligan, Nadine Rouphael, Maria L. Alcaide, Kay M. Tomashek, Chris Focht, William D. Martin, Leonard Moise, Anne S. De Groot, Daniel F. Hoft
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Zika virus (ZIKV) is a flavivirus primarily transmitted by Aedes species mosquitoes, first discovered in Africa in 1947, that disseminated through Southeast Asia and the Pacific Islands in the 2000s. The first ZIKV infections in the Americas were ide
Externí odkaz:
https://doaj.org/article/ab83e318f0cb4dbabe18cdf845f5b0cf
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionTuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) infection is a serious threat to human health. Vaccination with BCG prevents the development of the most severe forms of TB disease in infants and was recently shown to prevent
Externí odkaz:
https://doaj.org/article/ce73115f6151483389d0adc2853bc04a
Autor:
Johannes B. Goll, Steven E. Bosinger, Travis L. Jensen, Hasse Walum, Tyler Grimes, Gregory K. Tharp, Muktha S. Natrajan, Azra Blazevic, Richard D. Head, Casey E. Gelber, Kristen J. Steenbergen, Nirav B. Patel, Patrick Sanz, Nadine G. Rouphael, Evan J. Anderson, Mark J. Mulligan, Daniel F. Hoft
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/cfd74444a3174492acd623dd7d76e410
Autor:
Johannes B. Goll, Steven E. Bosinger, Travis L. Jensen, Hasse Walum, Tyler Grimes, Gregory K. Tharp, Muktha S. Natrajan, Azra Blazevic, Richard D. Head, Casey E. Gelber, Kristen J. Steenbergen, Nirav B. Patel, Patrick Sanz, Nadine G. Rouphael, Evan J. Anderson, Mark J. Mulligan, Daniel F. Hoft
Publikováno v:
Frontiers in Immunology, Vol 13 (2023)
IntroductionOver the last decade, the field of systems vaccinology has emerged, in which high throughput transcriptomics and other omics assays are used to probe changes of the innate and adaptive immune system in response to vaccination. The goal of
Externí odkaz:
https://doaj.org/article/109bbbaa3ceb45f799889d376b12096c
Autor:
Daniel F. Hoft, Azra Blazevic, Asmir Selimovic, Aldin Turan, Jan Tennant, Getahun Abate, John Fulkerson, Daniel E. Zak, Robert Walker, Bruce McClain, Jerry Sadoff, Judy Scott, Barbara Shepherd, Jasur Ishmukhamedov, David A. Hokey, Veerabadran Dheenadhayalan, Smitha Shankar, Lynn Amon, Garnet Navarro, Rebecca Podyminogin, Alan Aderem, Lew Barker, Michael Brennan, Robert S. Wallis, Anne A. Gershon, Michael D. Gershon, Sharon Steinberg
Publikováno v:
EBioMedicine, Vol 7, Iss C, Pp 278-286 (2016)
Background: We report a first-in-human trial evaluating safety and immunogenicity of a recombinant BCG, AERAS-422, over-expressing TB antigens Ag85A, Ag85B, and Rv3407 and expressing mutant perfringolysin. Methods: This was a randomized, double-blind
Externí odkaz:
https://doaj.org/article/247fad6c17484ca8917acc90c57cd726
Autor:
Charles T Spencer, Getahun Abate, Isaac G Sakala, Mei Xia, Steven M Truscott, Christopher S Eickhoff, Rebecca Linn, Azra Blazevic, Sunil S Metkar, Guangyong Peng, Christopher J Froelich, Daniel F Hoft
Publikováno v:
PLoS Pathogens, Vol 9, Iss 1, p e1003119 (2013)
Human γ(9)δ(2) T cells potently inhibit pathogenic microbes, including intracellular mycobacteria, but the key inhibitory mechanism(s) involved have not been identified. We report a novel mechanism involving the inhibition of intracellular mycobact
Externí odkaz:
https://doaj.org/article/7e461b845d7349aa8572e4c47139d982
Autor:
Christopher S Eickhoff, Jose R Vasconcelos, Nicole L Sullivan, Azra Blazevic, Oscar Bruna-Romero, Mauricio M Rodrigues, Daniel F Hoft
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 5, Iss 3, p e983 (2011)
Immunization of mice with the Trypanosoma cruzi trans-sialidase (TS) gene using plasmid DNA, adenoviral vector, and CpG-adjuvanted protein delivery has proven highly immunogenic and provides protection against acute lethal challenge. However, long-te
Externí odkaz:
https://doaj.org/article/b81d04eacb3e431bb120f261d2a1246c
Autor:
Johannes B. Goll, Steven E. Bosinger, Travis L. Jensen, Hasse Walum, Tyler Grimes, Gregory D. Tharp, Muktha S Natrajan, Azra Blazevic, Rich Head, Casey E. Gelber, Nirav B. Patel, Patrick Sanz, Nadine G. Rouphael, Evan J. Anderson, Mark J. Mulligan, Daniel F Hoft
Over the last decade, the field of systems vaccinology has emerged, in which high throughput transcriptomics and other omics assays are used to probe changes of the innate and adaptive immune system in response to vaccination. RNA-Seq technology has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a235e981a75fdfc1dc62619012d871b7
https://doi.org/10.1101/2022.06.23.497396
https://doi.org/10.1101/2022.06.23.497396