Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Azmiri Sultana"'
Autor:
Clare Burn Aschner, Krithika Muthuraman, Iga Kucharska, Hong Cui, Katherine Prieto, Manoj S. Nair, Maple Wang, Yaoxing Huang, Natasha Christie-Holmes, Betty Poon, Jessica Lam, Azmiri Sultana, Robert Kozak, Samira Mubareka, John L. Rubinstein, Edurne Rujas, Bebhinn Treanor, David D. Ho, Arif Jetha, Jean-Philippe Julien
Publikováno v:
Science Translational Medicine. 15
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), has been responsible for a global pandemic. Monoclonal antibodies (mAbs) have been used as antiviral therapeutics; however, thes
Autor:
Clare Burn Aschner, Krithika Muthuraman, Iga Kucharska, Hong Cui, Katherine Prieto, Manoj S. Nair, Maple Wang, Yaoxing Huang, Natasha Christie-Holmes, Betty Poon, Jessica Lam, Azmiri Sultana, Robert Kozak, Samira Mubareka, John L. Rubinstein, Edurne Rujas, Bebhinn Treanor, David D. Ho, Arif Jetha, Jean-Philippe Julien
SARS-CoV-2, the causative agent of COVID-19, has been responsible for a global pandemic. Monoclonal antibodies have been used as antiviral therapeutics, but have been limited in efficacy by viral sequence variability in emerging variants of concern (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14dc25df953b04a4c984f67151d9ce47
https://doi.org/10.1101/2022.10.23.513379
https://doi.org/10.1101/2022.10.23.513379
Publikováno v:
Nature. 534:562-565
Fertilization is an essential biological process in sexual reproduction and comprises a series of molecular interactions between the sperm and egg. The fusion of the haploid spermatozoon and oocyte is the culminating event in mammalian fertilization,
Publikováno v:
Proceedings of the National Academy of Sciences. 104:6170-6175
Aclacinomycin (Acl) oxidoreductase (AknOx) catalyzes the last two steps in the biosynthesis of polyketide antibiotics of the Acl group, the oxidation of the terminal sugar moiety rhodinose to l -aculose. We present the crystal structure of AknOx with
Publikováno v:
Acta Crystallographica Section D Biological Crystallography. 63:149-159
The crystal structure of aclacinomycin oxidoreductase (AknOx), a tailoring enzyme involved in the biosynthesis of the polyketide antibiotic aclacinomycin, was determined to 1.65 A resolution by multiwavelength anomalous diffraction using data from se
Structure of the polyketide cyclase SnoaL reveals a novel mechanism for enzymatic aldol condensation
Autor:
Azmiri Sultana, Pauli Kallio, Jarmo Niemi, Pekka Mäntsälä, Ji-Shu Wang, Gunter Schneider, Anna Jansson
Publikováno v:
The EMBO Journal. 23:1911-1921
SnoaL belongs to a family of small polyketide cyclases, which catalyse ring closure steps in the biosynthesis of polyketide antibiotics produced in Streptomyces. Several of these antibiotics are among the most used anti-cancer drugs currently in use.
Publikováno v:
Nature communications
The human APOBEC3 family of DNA cytosine deaminases serves as a front-line intrinsic immune response to inhibit the replication of diverse retroviruses. APOBEC3F and APOBEC3G are the most potent factors against HIV-1. As a countermeasure, HIV-1 viral
Autor:
Sara R. Hanscom, Patrick Lall, Shun-ichiro Oda, Azmiri Sultana, Conor P. Horgan, Edward Franklin, Amir R. Khan, Mary W. McCaffrey
Publikováno v:
Biochimica et biophysica acta. 1834(12)
Rab small GTPases are the master regulators of intracellular trafficking in eukaryotes. They mediate spatial and temporal recruitment of effector proteins to distinct cellular compartments through GTP-induced changes in their conformation. Despite nu
Publikováno v:
FEBS letters. 585(22)
Rab GTPases localize to distinct sub-cellular compartments and regulate vesicle trafficking in eukaryotic cells. Yeast Rabs Ypt31/32 and Sec4 have 68% homology and bind to common interactors, yet play distinct roles in the transport of exocytic vesic
Publikováno v:
Journal of molecular biology. 357(1)
AknH is a small polyketide cyclase that catalyses the closure of the fourth carbon ring in aclacinomycin biosynthesis in Streptomyces galilaeus, converting aklanonic acid methyl ester to aklaviketone. The crystal structure analysis of this enzyme, in