Impairment of Nrf2 signaling in the hippocampus of P301S tauopathy mice model aligns with the cognitive impairment and the associated neuroinflammation

Autor: Ahmed Sabry Mohamed, Mahmoud ElKaffas, Karim Metwally, Mahmoud Abdelfattah, Eslam Ashraf Elsery, Ahmed Elshazly, Hossam Eldin Gomaa, Aziza Alsayed, Sara El-Desouky, Randa El-Gamal, Sara Elfarrash

Publikováno v: Journal of Inflammation, Vol 21, Iss 1, Pp 1-13 (2024)

Abstract Mice transgenic for human P301S tau protein exhibit many characteristics of the human tauopathies, including the formation of abundant hyperphoshorylated tau filaments, the associated neuroinflammation and disease phenotype. However, the exa

Externí odkaz: https://doaj.org/article/35b57d7b780347238496da07da4d1c55

A Novel Animal Model Prepared by Blocking (FOXRED1 gene) for neuro-toxicological studies of Leigh Syndrome

Autor: Wael Mohamed Yousef Mohamed, Mahmoud El-Hussiny, Emad Fekry, Sara El-Desouky, Mohamed Salama, Yasmeen M. Taalab, Abdelrahman Moustafa, Aziza Alsayed

Publikováno v: Mansoura Journal of Forensic Medicine and Clinical Toxicology. 27:77-86

Leigh syndrome (LS) is one of the most puzzling mitochondrial disorders, which is also known as subacute necrotizing encephalopathy. It has an incidence of 1 in 77,000 live births worldwide with poor prognosis. Currently, there is a poor understandin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::268bb6be62be240fcfaf57bd87bebca4
https://doi.org/10.21608/mjfmct.2019.46714

Dual mTORC1/mTORC2 blocker as a possible therapy for tauopathy in cellular model

Autor: Ahmed G. Omran, Wael Mohamed Yousef Mohamed, Mahmoud El-Hussiny, Aziza Alsayed, Ramy Ashry, Alshimaa Magdy, Mohamed Salama

Publikováno v: Metabolic Brain Disease. 33:583-587

Tauopathy comprises a group of disorders caused by abnormal aggregates of tau protein. In these disorders phosphorylated tau protein tends to accumulate inside neuronal cells (soma) instead of the normal axonal distribution of tau. A suggested therap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f22f767b0ffee74daea2335f7227768
https://doi.org/10.1007/s11011-017-0137-7

siRNA Blocking of Mammalian Target of Rapamycin (mTOR) Attenuates Pathology in Annonacin-Induced Tauopathy in Mice

Autor: Khaled Magdy, Mohamed Youssef, Wael Mohamed Yousef Mohamed, Osama Shabka, Mahmoud El-Hussiny, Mohamed Salama, Sabry A. El-Khodery, Mohamed A. Sobh, Emad Fekry, Sara El-Desouky, Aziza Alsayed

Publikováno v: Neurotoxicity research. 35(4)

Tauopathy is a pathological hallmark of many neurodegenerative diseases. It is characterized by abnormal aggregates of pathological phosphotau and somatodendritic redistribution. One suggested strategy for treating tauopathy is to stimulate autophagy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b33a21daf3c464025804469f1553608d
https://pubmed.ncbi.nlm.nih.gov/30362086

Long term study of protective mechanisms of human adipose derived mesenchymal stem cells on cisplatin induced kidney injury in Sprague-Dawley rats

Autor: Mohamed-Ahmed Sobh, Hussein Sheashaa, Aziza Alsayed, Sara El-Dusoky, Fatma Elhusseini, Nahla Anber, Mohamed-Ahdy Saad, Doaa M. Elghannam, Mohamed A. Sobh, Hassan Abdel-Ghaffar

Publikováno v: Scopus-Elsevier
Journal of Stem Cells & Regenerative Medicine
Journal of Stem Cells and Regenerative Medicine, Vol 12, Iss 1, Pp 36-48 (2016)
Publons

Background/Aims: Long-term evaluation of cisplatin induced nephrotoxicity and the probable renal protective activities of stem cells are lacking up until now. We evaluated the early and long-term role of human adipose derived mesenchymal stem cells (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::359319cbb4114498b228c2bd6910598c
http://www.scopus.com/inward/record.url?eid=2-s2.0-84973103430&partnerID=MN8TOARS