Zobrazeno 1 - 10 of 18 pro vyhledávání: '"Aziza A A Adam"'
1
Akademický článek
A practice-changing culture method relying on shaking substantially increases mitochondrial energy metabolism and functionality of human liver cell lines.
Autor: Aziza A A Adam, Vincent A van der Mark, Joanne M Donkers, Manon E Wildenberg, Ronald P J Oude Elferink, Robert A F M Chamuleau, Ruurdtje Hoekstra
Publikováno v: PLoS ONE, Vol 13, Iss 4, p e0193664 (2018)
Practice-changing culturing techniques of hepatocytes are highly required to increase their differentiation. Previously, we found that human liver cell lines HepaRG and C3A acquire higher functionality and increased mitochondrial biogenesis when cult
Externí odkaz: https://doaj.org/article/dda135b9f4ac477fa76ca8c842d09a26
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2
Akademický článek
Apoptotic Potential of Glucomoringin Isothiocyanate (GMG-ITC) Isolated from Moringa oleifera Lam Seeds on Human Prostate Cancer Cells (PC-3)
Autor: Nurul Ashikin Abd Karim, Aziza Hussein Bakheit Adam, Mohammed Sani Jaafaru, Yaya Rukayadi, Ahmad Faizal Abdull Razis
Publikováno v: Molecules, Vol 28, Iss 7, p 3214 (2023)
Inhibition of several protein pathways involved in cancer cell regulation is a necessary key in the discovery of cancer chemotherapy. Moringa oleifera Lam is often used in traditional medicine for the treatment of various illnesses. The plant contain
Externí odkaz: https://doaj.org/article/b4eb6e6c1ef2420c8de8ca1aa4bb1e9d
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3
Estrogen receptor alpha (ERα)–mediated coregulator binding and gene expression discriminates the toxic ERα agonist diethylstilbestrol (DES) from the endogenous ERα agonist 17β-estradiol (E2)
Autor: Ignacio Miro Estruch, Laura H.J. de Haan, Aziza Hussein Bakheit Adam, Jochem Louisse, Guido J. E. J. Hooiveld, Ivonne M.C.M. Rietjens
Publikováno v: Cell biology and toxicology, 36, 417-435
Cell Biology and Toxicology
Cell biology and toxicology 36 (2020)
Diethylstilbestrol (DES) is a synthetic estrogen and proven human teratogen and carcinogen reported to act via the estrogen receptor α (ERα). Since the endogenous ERα ligand 17β-estradiol (E2) does not show these adverse effects to a similar exte
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eee929827f519f22528090d1698165a4
https://doi.org/10.1007/s10565-020-09516-6
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4
Assessment of the in vitro developmental toxicity of diethylstilbestrol and estradiol in the zebrafish embryotoxicity test
Autor: Aziza Hussein Bakheit Adam, Lenny Kamelia, Jochem Louisse, Ivonne M.C.M. Rietjens, Laura H.J. de Haan
Publikováno v: Toxicology in Vitro 72 (2021)
Toxicology in Vitro, 72
The present study investigated the developmental toxicity of diethylstilbestrol (DES) in the zebrafish embryotoxicity test (ZET). This was done to investigate whether the ZET would better capture the developmental toxicity of DES than the embryonic s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64c2ef32d2d0f5cf3892850c3e881082
https://pubmed.ncbi.nlm.nih.gov/33429043
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5
Overexpression of the constitutive androstane receptor and shaken 3D-culturing increase biotransformation and oxidative phosphorylation and sensitivity to mitochondrial amiodarone toxicity of HepaRG cells
Autor: Vincent A. van der Mark, Aziza A. A. Adam, Ronald P.J. Oude Elferink, Ruurdtje Hoekstra, Jung-Chin Chang, Robert A. F. M. Chamuleau
Publikováno v: Toxicology and applied pharmacology, 399:115055. Academic Press Inc.
The liver cell line HepaRG is one of the preferred sources of human hepatocytes for in vitro applications. However, mitochondrial energy metabolism is relatively low, which affects hepatic functionality and sensitivity to hepatotoxins. Culturing in a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adf35c552b5d892608f89306eed2c438
https://pubmed.ncbi.nlm.nih.gov/32428594
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6
Studying the role of estrogen receptor alpha in the developmental toxicity of diethylstilbestrol using alternative testing strategies
Autor: Aziza Hussein Bakheit Adam
Diethylstilbestrol (DES) is a synthetic estrogen that has been used between the 1940s and 1970s by pregnant women to prevent miscarriages and premature delivery by stimulating the synthesis of estrogen and progesterone in the placenta. However, use o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a942d32924105052b846f9de0f3c111
https://research.wur.nl/en/publications/studying-the-role-of-estrogen-receptor-alpha-in-the-developmental
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7
Improved oxygenation dramatically alters metabolism and gene expression in cultured primary mouse hepatocytes
Autor: Emy Luiza Ishii-Iwamoto, Arthur J. Verhoeven, Ruurdtje Hoekstra, Eduardo H. Gilglioni, Simei Go, Ronald P.J. Oude Elferink, Aziza A. A. Adam, Jung-Chin Chang, Suzanne Duijst
Publikováno v: Hepatology Communications
Hepatology communications, 2(3), 299-312. Wiley-Blackwell Publishing Ltd
Primary hepatocyte culture is an important in vitro system for the study of liver functions. In vivo, hepatocytes have high oxidative metabolism. However, oxygen supply by means of diffusion in in vitro static cultures is much less than that by blood
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26cb61dc8957ff9e546ebed1790b0634
http://europepmc.org/articles/PMC5831026
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8
HepaRG-Progenitor Cell Derived Hepatocytes Cultured in Bioartificial Livers Are Protected from Healthy- and Acute Liver Failure-Plasma Induced Toxicity
Autor: Ronald P.J. Oude Elferink, Thomas M. van Gulik, Vincent A. van der Mark, Philipp Treskes, Robert A. F. M. Chamuleau, Martien van Wenum, Aziza A. A. Adam, Aldo Jongejan, Ruurdtje Hoekstra, Perry D. Moerland
Publikováno v: Cellular Physiology and Biochemistry, Vol 48, Iss 5, Pp 2189-2204 (2018)
Cellular physiology and biochemistry, 48(5), 2189-2204. S. Karger AG
Background/Aims: For applicability of cell-based therapies aimed at the treatment of liver failure, such as bioartificial livers (BALs) and hepatocyte transplantation, it is essential that the applied hepatocytes tolerate exposure to the patient plas
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d74ae72275fa9dbad0975e70e79bf0f9
https://doi.org/10.1159/000492560
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9
Genome-wide expression profiling reveals increased stability and mitochondrial energy metabolism of the human liver cell line HepaRG-CAR
Autor: Robert A. F. M. Chamuleau, Ruurdtje Hoekstra, Perry D. Moerland, Ronald P.J. Oude Elferink, Aziza A. A. Adam, Vincent A. van der Mark, Aldo Jongejan
Publikováno v: Cytotechnology
Cytotechnology, 72(3), 377-395. Springer Netherlands
Human liver cell line HepaRG is a well-known source of human hepatocyte-like cells which, however, displays limited biotransformation and a tendency to transform after 20 passages. The new HepaRG-CAR cell line overexpressing constitutive androstane r
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::629b27b5076a4a0f28ddf96766f5c695
https://pubmed.ncbi.nlm.nih.gov/32130581
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10
The in vivo developmental toxicity of diethylstilbestrol (DES) in rat evaluated by an alternative testing strategy
Autor: Laura H.J. de Haan, Aziza Hussein Bakheit Adam, Ivonne M.C.M. Rietjens, Mengying Zhang, Jochem Louisse, Bennard van Ravenzwaay
Publikováno v: Archives of Toxicology 93 (2019) 7
Archives of Toxicology, 93(7), 2021-2033
In the present study, we evaluated an alternative testing strategy to quantitatively predict the in vivo developmental toxicity of the synthetic hormone diethylstilbestrol (DES). To this end, a physiologically based kinetic (PBK) model was defined th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aa72f6caee1f2b650d882cd0f895689
https://research.wur.nl/en/publications/the-in-vivo-developmental-toxicity-of-diethylstilbestrol-des-in-r
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