Zobrazeno 1 - 10
of 1 032
pro vyhledávání: '"Aziz Sancar"'
Publikováno v:
PLoS Genetics, Vol 20, Iss 7, p e1011365 (2024)
Bulky DNA adducts such as those induced by ultraviolet light are removed from the genomes of multicellular organisms by nucleotide excision repair, which occurs through two distinct mechanisms, global repair, requiring the DNA damage recognition-fact
Externí odkaz:
https://doaj.org/article/0e4d7f0ca5794a5b85b0fb41f21d3a8f
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Ultraviolet (UV) component of solar radiation impairs genome stability by inducing the formation of pyrimidine-pyrimidone (6-4) photoproducts [(6-4)PPs] in plant genomes. (6-4)PPs disrupt growth and development by interfering with transcript
Externí odkaz:
https://doaj.org/article/12a688202f2b47debdc57cbb77b969e9
Autor:
Yanchao Huang, Cem Azgari, Mengdie Yin, Yi-Ying Chiou, Laura A Lindsey-Boltz, Aziz Sancar, Jinchuan Hu, Ogun Adebali
Publikováno v:
PLoS Genetics, Vol 18, Iss 9, p e1010426 (2022)
Nucleotide excision repair is the primary repair mechanism that removes UV-induced DNA lesions in placentals. Unrepaired UV-induced lesions could result in mutations during DNA replication. Although the mutagenesis of pyrimidine dimers is reasonably
Externí odkaz:
https://doaj.org/article/fa5438d4960a4abcbfa118a51c87149a
Autor:
Umit Akkose, Veysel Ogulcan Kaya, Laura Lindsey-Boltz, Zeynep Karagoz, Adam D. Brown, Peter A. Larsen, Anne D. Yoder, Aziz Sancar, Ogun Adebali
Publikováno v:
BMC Genomics, Vol 22, Iss 1, Pp 1-13 (2021)
Abstract Background Nucleotide excision repair is the primary DNA repair mechanism that removes bulky DNA adducts such as UV-induced pyrimidine dimers. Correspondingly, genome-wide mapping of nucleotide excision repair with eXcision Repair sequencing
Externí odkaz:
https://doaj.org/article/6d7ecff62a1e4c39b71eb70efd7d8f16
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Cisplatin, a platinum chemotherapeutic agent, is widely used to treat several cancers. Here Yimit et al. revert to genome-wide approaches to map and analyze cisplatin damage formation and excision repair with single nucleotide resolution across diffe
Externí odkaz:
https://doaj.org/article/e8c9077bcabd4f6dbd5440dc994c0977
Autor:
Laura A. Lindsey-Boltz, Aziz Sancar
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
The mfd (mutation frequency decline) gene was identified by screening an auxotrophic Escherichia coli strain exposed to UV and held in a minimal medium before plating onto rich or minimal agar plates. It was found that, under these conditions, holdin
Externí odkaz:
https://doaj.org/article/9c61477203054b4ca15e20e660c0820c
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
The transcription-translation feedback loop (TTFL) is the core mechanism of the circadian rhythm. In mammalian cells, CLOCK-BMAL1 proteins activate the downstream genes by binding on the E-box sequence of the clock-controlled genes. Among these gene
Externí odkaz:
https://doaj.org/article/b4c03b5b2eec4afb9356e2d737528733
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
Plants use nucleotide excision repair to maintain genome integrity in response to damage caused by stresses such as UV radiation. Here Oztas et al. use genome-wide profiling to show that excision repair in Arabidopsis is strongly coupled to transcrip
Externí odkaz:
https://doaj.org/article/20ce9808d2ae4e69b9bccd3722398343
Autor:
Hagoon Jang, Gha Young Lee, Christopher P. Selby, Gung Lee, Yong Geun Jeon, Jae Ho Lee, Kenneth King Yip Cheng, Paul Titchenell, Morris J. Birnbaum, Aimin Xu, Aziz Sancar, Jae Bum Kim
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
The clock protein Cry regulates hepatic glucose metabolism. Here the authors show that SREBP1c, activated by insulin signalling after feeding, directly regulates Cry transcription at specific circadian time points, and that Cry represses hepatic gluc
Externí odkaz:
https://doaj.org/article/8d7c5bde883440f7b735e96aacbc548c
Multiple ATR-Chk1 pathway proteins preferentially associate with checkpoint-inducing DNA substrates.
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e22986 (2011)
The ATR-Chk1 DNA damage checkpoint pathway is a critical regulator of the cellular response to DNA damage and replication stress in human cells. The variety of environmental, chemotherapeutic, and carcinogenic agents that activate this signal transdu
Externí odkaz:
https://doaj.org/article/83aaec6ddeb14068a3c9959b24eb77e9