Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Aziz Ouach"'
Autor:
Agnes Chartier, Frédéric Buron, Liliana Boiaryna, Pakorn Tangpong, Aziz Ouach, Frederic Pin, Sylvain Routier, Denis Guilloteau, Emilie Bertrand, Jean-Bernard Deloye, Zuhal Gulhan, Nuno Rodrigues, Johnny Vercouillie, Guylène Page, Céline Mothes, Sophie Serrière, Nathalie Percina, Franck Suzenet, Sylvie Chalon
Publikováno v:
European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2019, 179, pp.449-469. ⟨10.1016/j.ejmech.2019.06.049⟩
European Journal of Medicinal Chemistry, 2019, 179, pp.449-469. ⟨10.1016/j.ejmech.2019.06.049⟩
European Journal of Medicinal Chemistry, Elsevier, 2019, 179, pp.449-469. ⟨10.1016/j.ejmech.2019.06.049⟩
European Journal of Medicinal Chemistry, 2019, 179, pp.449-469. ⟨10.1016/j.ejmech.2019.06.049⟩
In this paper we describe the design and synthesis of bis(Het)Aryl-1,2,3-triazole quinuclidine α7R ligands using an efficient three-step sequence including a Suzuki-Miyaura cross coupling reaction with commercially available and home-made boron deri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0914b3f04569040b60720ff93522728e
https://www.hal.inserm.fr/inserm-02458368
https://www.hal.inserm.fr/inserm-02458368
Autor:
Aziz, Ouach, Johnny, Vercouillie, Emilie, Bertrand, Nuno, Rodrigues, Frederic, Pin, Sophie, Serriere, Liliana, Boiaryna, Agnes, Chartier, Nathalie, Percina, Pakorn, Tangpong, Zuhal, Gulhan, Celine, Mothes, Jean-Bernard, Deloye, Denis, Guilloteau, Guylene, Page, Franck, Suzenet, Frederic, Buron, Sylvie, Chalon, Sylvain, Routier
Publikováno v:
European journal of medicinal chemistry. 179
In this paper we describe the design and synthesis of bis(Het)Aryl-1,2,3-triazole quinuclidine α7R ligands using an efficient three-step sequence including a Suzuki-Miyaura cross coupling reaction with commercially available and home-made boron deri
Autor:
Olivier Lozach, Myriam Ravache, Laurent Meijer, Sandrine Ruchaud, Pascal Bonnet, Mohamed Akssira, Yves Troin, Rémy Le Guével, Said Lazar, Aziz Ouach, Gérald Guillaumet, Christine Vala, Sylvain Routier, Stéphane Bourg, Christiane Guguen-Guillouzo, Rajâa Boulahjar
Publikováno v:
European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2016, 115, pp.311-325. ⟨10.1016/j.ejmech.2016.02.072⟩
European Journal of Medicinal Chemistry, 2016, 115, pp.311--325. ⟨10.1016/j.ejmech.2016.02.072⟩
European Journal of Medicinal Chemistry, Elsevier, 2016, 115, pp.311--325. ⟨10.1016/j.ejmech.2016.02.072⟩
European Journal of Medicinal Chemistry, Elsevier, 2016, 115, pp.311-325. ⟨10.1016/j.ejmech.2016.02.072⟩
European Journal of Medicinal Chemistry, 2016, 115, pp.311--325. ⟨10.1016/j.ejmech.2016.02.072⟩
European Journal of Medicinal Chemistry, Elsevier, 2016, 115, pp.311--325. ⟨10.1016/j.ejmech.2016.02.072⟩
International audience; An efficient synthetic strategy able to modulate the structure of the tetrahydropyridine isoindolone (Valmerin) skeleton was developed. A library of more than 30 novel final structures was generated. Biological activities on C
Publikováno v:
Synthesis. 2010:783-790
A new route to the first N-methyloxoarcyriaflavin was designed. The compound was obtained by a palladium-catalyzed Stille cross-coupling reaction, followed by an electrophilic cyclization onto a C-2 indolic position as a key step.
Autor:
Jean-Bernard Deloye, Zuhal Gulhan, Frederic Pin, Denis Guilloteau, Emilie Bertrand, Céline Mothes, Sylvie Chalon, Sylvain Routier, Johnny Vercouillie, Franck Suzenet, Aziz Ouach
Publikováno v:
European journal of medicinal chemistry. 107
We report here the synthesis of a large library of 1,2,3-triazole derivatives which were in vitro tested as α7 nAchR ligands. The SAR study revealed that several crucial factors are involved in the affinity of these compounds for α7 nAchR such as a
Autor:
Gérald Guillaumet, Olivier Lozach, Pascal Bonnet, Said Lazar, Rajâa Boulahjar, Laurent Meijer, Aziz Ouach, Yves Troin, Mohamed Akssira, Christiane Guguen-Guillouzo, Rémy Le Guével, Sylvain Routier, Stéphane Bourg
Publikováno v:
European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, 2015, 101, pp.274-287. ⟨10.1016/j.ejmech.2015.06.046⟩
European Journal of Medicinal Chemistry, Elsevier, 2015, 101, pp.274-287. ⟨10.1016/j.ejmech.2015.06.046⟩
European Journal of Medicinal Chemistry, 2015, 101, pp.274-287. ⟨10.1016/j.ejmech.2015.06.046⟩
European Journal of Medicinal Chemistry, Elsevier, 2015, 101, pp.274-287. ⟨10.1016/j.ejmech.2015.06.046⟩
International audience; An efficient synthetic strategy was developed to modulate the structure of the tetrahydropyridine isoindolone (Valmerin) skeleton. A library of more than 30 novel final structures was generated. Biological activities on CDK5 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de4a3bb5564bf92227f62f4aed8fb848
https://hal.science/hal-01212495
https://hal.science/hal-01212495
Autor:
Gabrielle Chicheri, Zuhal Gulhan, Jean-Bernard Deloye, Stéphane Massip, Aziz Ouach, Franck Suzenet, Sylvie Chalon, Denis Guilloteau, Sylvie Mavel, Frederic Pin, Johnny Vercouillie, Christian Jarry, Sylvain Routier
Publikováno v:
European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, 2014, 82, pp.214-224. ⟨10.1016/j.ejmech.2014.04.057⟩
European Journal of Medicinal Chemistry, Elsevier, 2014, 82, pp.214-224. ⟨10.1016/j.ejmech.2014.04.057⟩
European Journal of Medicinal Chemistry, 2014, 82, pp.214-224. ⟨10.1016/j.ejmech.2014.04.057⟩
European Journal of Medicinal Chemistry, Elsevier, 2014, 82, pp.214-224. ⟨10.1016/j.ejmech.2014.04.057⟩
International audience; In this report, we describe the synthesis of a novel library of $\alpha$7 nAChR ligands based on the modulationof the quinuclidine, quinazoline and tropane moieties. Spirane derivatives were newly synthesized understereo speci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53f999d4ba2617e34d99961b07ff8c1f
https://univ-tours.hal.science/hal-01826403
https://univ-tours.hal.science/hal-01826403
Autor:
Aziz Ouach, Thibauld Oullier, Christiane Guguen-Guillouzo, Sylvain Routier, Rajâa Boulahjar, Gérald Guillaumet, Olivier Lozach, Laurent Meijer, Said Lazar, Chiurato Matteo, Stéphane Bourg, Myriam Ravache, Mohamed Akssira, Séverine Marionneau, Rémy Le Guével, Yves Troin
Publikováno v:
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2012, 55 (22), pp.9589-9606. ⟨10.1021/jm3008536⟩
Journal of Medicinal Chemistry, American Chemical Society, 2012, 55, pp.9589-9606
Journal of Medicinal Chemistry, 2012, 55, pp.9589-9606
Journal of Medicinal Chemistry, 2012, 55 (22), pp.9589-9606. ⟨10.1021/jm3008536⟩
Journal of Medicinal Chemistry, American Chemical Society, 2012, 55 (22), pp.9589-9606. ⟨10.1021/jm3008536⟩
Journal of Medicinal Chemistry, American Chemical Society, 2012, 55, pp.9589-9606
Journal of Medicinal Chemistry, 2012, 55, pp.9589-9606
Journal of Medicinal Chemistry, 2012, 55 (22), pp.9589-9606. ⟨10.1021/jm3008536⟩
International audience; The development of CDK and GSK3 inhibitors has been regarded as a potential therapeutic approach, and a substantial number of diverse structures have been reported to inhibit CDKs and GSK-3β in recent years. Only a few molecu
Publikováno v:
ChemInform. 42
Stereocontrolled Tsuji—Trost reaction of various γ-borylated allylic acetates is achieved using malonate, β-ketoester, 3-diketone, cyanoacetate or a cyclic ketoester as nucleophiles.
Publikováno v:
Organic letters. 13(15)
Three-carbon highly functionalized γ-borylated allylic acetates underwent a regio- and stereocontrolled Tsuji-Trost reaction in the presence of palladium complexes. An ipso substitution of the acetate with complete stereoretention of the chiral cent