Integrative genotyping of cancer and immune phenotypes by long-read sequencing

Autor: Livius Penter, Mehdi Borji, Adi Nagler, Haoxiang Lyu, Wesley S. Lu, Nicoletta Cieri, Katie Maurer, Giacomo Oliveira, Aziz M. Al’Khafaji, Kiran V. Garimella, Shuqiang Li, Donna S. Neuberg, Jerome Ritz, Robert J. Soiffer, Jacqueline S. Garcia, Kenneth J. Livak, Catherine J. Wu

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)

Abstract Single-cell transcriptomics has become the definitive method for classifying cell types and states, and can be augmented with genotype information to improve cell lineage identification. Due to constraints of short-read sequencing, current m

Externí odkaz: https://doaj.org/article/db7bcebda28b4a739047f63c97488177

Functionalized Lineage Tracing Can Enable the Development of Homogenization-Based Therapeutic Strategies in Cancer

Autor: Catherine Gutierrez, Caroline K. Vilas, Catherine J. Wu, Aziz M. Al’Khafaji

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

The therapeutic landscape across many cancers has dramatically improved since the introduction of potent targeted agents and immunotherapy. Nonetheless, success of these approaches is too often challenged by the emergence of therapeutic resistance, f

Externí odkaz: https://doaj.org/article/79c4ecbd456b4116944a02ea0e89a8c3

Multifunctional barcoding with ClonMapper enables high-resolution study of clonal dynamics during tumor evolution and treatment.

Autor: Gutierrez C; Harvard Medical School, Boston, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; These authors contributed equally: Catherine Gutierrez, Aziz M. Al'Khafaji, Eric Brenner., Al'Khafaji AM; Institute of Cellular and Molecular Biology, University of Texas at Austin, Austin, TX, USA.; Department of Biomedical Engineering, University of Texas at Austin, Austin, TX, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; These authors contributed equally: Catherine Gutierrez, Aziz M. Al'Khafaji, Eric Brenner., Brenner E; Institute of Cellular and Molecular Biology, University of Texas at Austin, Austin, TX, USA.; Department of Biomedical Engineering, University of Texas at Austin, Austin, TX, USA.; These authors contributed equally: Catherine Gutierrez, Aziz M. Al'Khafaji, Eric Brenner., Johnson KE; Department of Biomedical Engineering, University of Texas at Austin, Austin, TX, USA., Gohil SH; Harvard Medical School, Boston, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Academic Haematology, University College London, London, UK.; Department of Clinical Haematology, University College London Hospitals NHS Foundation Trust, London, UK., Lin Z; Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Harvard University, Cambridge, MA, USA., Knisbacher BA; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Durrett RE; Institute of Cellular and Molecular Biology, University of Texas at Austin, Austin, TX, USA.; Department of Biomedical Engineering, University of Texas at Austin, Austin, TX, USA., Li S; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Translational Immunogenomics Laboratory, Dana-Farber Cancer Institute, Boston, MA, USA., Parvin S; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Biran A; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Zhang W; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Rassenti L; Department of Medicine, University of California at San Diego Moores Cancer Center, La Jolla, CA, USA., Kipps TJ; Department of Medicine, University of California at San Diego Moores Cancer Center, La Jolla, CA, USA., Livak KJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Translational Immunogenomics Laboratory, Dana-Farber Cancer Institute, Boston, MA, USA., Neuberg D; Department of Data Sciences, Dana Farber Cancer Institute, Boston, MA, USA., Letai A; Harvard Medical School, Boston, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Getz G; Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA., Wu CJ; Harvard Medical School, Boston, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Brock A; Institute of Cellular and Molecular Biology, University of Texas at Austin, Austin, TX, USA.; Department of Biomedical Engineering, University of Texas at Austin, Austin, TX, USA.

Publikováno v: Nature cancer [Nat Cancer] 2021 Jul; Vol. 2 (7), pp. 758-772. Date of Electronic Publication: 2021 Jul 12.