Fragment-Based Identification of a Locus in the Sec7 Domain of Arno for the Design of Protein-Protein Interaction Inhibitors

Autor: Romain Trouillard, François Hoh, Jad Rouhana, Alain Chavanieu, Yvan Boublik, André Padilla, Corinne Henriquet, Martine Pugnière, Sebastien Estaran, Aziz Kerkour, Jean Martinez

Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2013, 56 (8497−8511), epub ahead of print. ⟨10.1021/jm4009357⟩

International audience; By virtual screening using a fragment-based drug design (FBDD) approach, 33 fragments were selected within small pockets around interaction hot spots on the Sec7 surface of the nucleotide exchange factor Arno, and then their a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31662dc539a3675f1eebc4a2f9081aef
https://hal.archives-ouvertes.fr/hal-00905451