Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Aziz Cayli"'
Autor:
Gizem Celebi Torabfam, Abuzer Alp Yetisgin, Cem Erdem, Aziz Cayli, Ozlem Kutlu, Sibel Cetinel
Publikováno v:
Cytotechnology. 74:635-655
Lentivirus and adeno-associated viruses are invaluable tools for biotechnology applications due to their genetic material delivery abilities both in vitro and in vivo. However, their large-scale productions with Good Manufacturing Practices yield low
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::769d5bb11c6ffd56a83104c5407ed1df
https://doi.org/10.1007/s10616-022-00551-1
https://doi.org/10.1007/s10616-022-00551-1
Publikováno v:
Biotechnology and Bioengineering. 65:192-200
The glycosylation of pharmaglycoproteins from recombinant cell lines can be affected by an uncontrolled accumulation of ammonium in the medium. Glucosamine-6-phosphate isomerase (GPI) has been proposed as the key enzyme responsible for elevating the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7b903cbe60df30eff0eefa5421d7b4e
https://doi.org/10.1002/(sici)1097-0290(19991020)65:2<192::aid-bit9>3.0.co
https://doi.org/10.1002/(sici)1097-0290(19991020)65:2<192::aid-bit9>3.0.co
Publikováno v:
New Developments and New Applications in Animal Cell Technology ISBN: 0792350162
Glucosamine-6-phosphate isomerase has been identified as the ammonium accepting enzyme resulting in an elevated UDPGNAc content under high ammonium concentrations. GPI was efficiently inhibited using two different strategies: The addition of mannose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20c2590e25d1234cc36a533824a44274
https://doi.org/10.1007/0-306-46860-3_28
https://doi.org/10.1007/0-306-46860-3_28
Autor:
Aziz Cayli, Alexandra Baer, Hansjörg Hauser, Roland Schucht, Wolfgang Krömer, Kristina Nehlsen, Dagmar Wirth, L. Gama-Norton
Publikováno v:
BMC Biotechnology
BMC Biotechnology, Vol 9, Iss 1, p 100 (2009)
BMC Biotechnology, Vol 9, Iss 1, p 100 (2009)
Background Recombinant protein expression in mammalian cells is mostly achieved by stable integration of transgenes into the chromosomal DNA of established cell lines. The chromosomal surroundings have strong influences on the expression of transgene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67a2610888bb674a14c64cb45328d274
http://europepmc.org/articles/PMC2804664
http://europepmc.org/articles/PMC2804664