Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Aziz, El Hage"'
Autor:
Aziz El Hage, Susana M. Cerritelli
Publikováno v:
Curr Genet
Cerritelli, S M & El Hage, A 2020, ' RNases H1 and H2 : Guardians of the stability of the nuclear genome when supply of dNTPs is limiting for DNA synthesis ', Current Genetics . https://doi.org/10.1007/s00294-020-01086-8
Cerritelli, S M & El Hage, A 2020, ' RNases H1 and H2 : Guardians of the stability of the nuclear genome when supply of dNTPs is limiting for DNA synthesis ', Current Genetics . https://doi.org/10.1007/s00294-020-01086-8
RNA/DNA hybrids are processed by RNases H1 and H2, while single ribonucleoside-monophosphates (rNMPs) embedded in genomic DNA are removed by the error-free, RNase H2-dependent ribonucleotide excision repair (RER) pathway. In the absence of RER, howev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b43de25fe2673accccdc3bb2f7ec748
https://doi.org/10.1007/s00294-020-01086-8
https://doi.org/10.1007/s00294-020-01086-8
Publikováno v:
PLoS Genetics, Vol 10, Iss 10, p e1004716 (2014)
During transcription, the nascent RNA can invade the DNA template, forming extended RNA-DNA duplexes (R-loops). Here we employ ChIP-seq in strains expressing or lacking RNase H to map targets of RNase H activity throughout the budding yeast genome. I
Externí odkaz:
https://doaj.org/article/7e8b045862bf44479bebd7e082246bab
Autor:
Sushma Sharma, Jaime Iranzo, Robert J. Crouch, Susana M. Cerritelli, Andrei Chabes, David Tollervey, Aziz El Hage
Publikováno v:
Cerritelli, S M, Iranzo, J, Sharma, S, Chabes, A, Crouch, R J, Tollervey, D & El hage, A 2020, ' High density of unrepaired genomic ribonucleotides leads to Topoisomerase 1-mediated severe growth defects in absence of ribonucleotide reductase ', Nucleic Acids Research . https://doi.org/10.1093/nar/gkaa103
Nucleic Acids Research
Nucleic Acids Research
Cellular levels of ribonucleoside triphosphates (rNTPs) are much higher than those of deoxyribonucleoside triphosphates (dNTPs), thereby influencing the frequency of incorporation of ribonucleoside monophosphates (rNMPs) by DNA polymerases (Pol) into
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39bf10ab9e1a3d11943d19b13e9b3921
https://www.pure.ed.ac.uk/ws/files/141999068/gkaa103.pdf
https://www.pure.ed.ac.uk/ws/files/141999068/gkaa103.pdf
Autor:
Aziz, El Hage, David, Tollervey
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1703
During transcription, the nascent transcript behind an elongating RNA polymerase (RNAP) can invade the DNA duplex and hybridize with the complementary DNA template strand, generating a three-stranded "R-loop" structure, composed of an RNA:DNA duplex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9eab1cf5242de60df5ffb5e625ba5a60
https://pubmed.ncbi.nlm.nih.gov/29177737
https://pubmed.ncbi.nlm.nih.gov/29177737
Autor:
David Tollervey, Aziz El Hage
Publikováno v:
Methods in Molecular Biology ISBN: 9781493974580
During transcription, the nascent transcript behind an elongating RNA polymerase (RNAP) can invade the DNA duplex and hybridize with the complementary DNA template strand, generating a three-stranded "R-loop" structure, composed of an RNA:DNA duplex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07a009f311321314c89e40b6e90ce07f
https://doi.org/10.1007/978-1-4939-7459-7_8
https://doi.org/10.1007/978-1-4939-7459-7_8
Autor:
Robert D. Hontz, Aziz El Hage, David Tollervey, Jeffrey S. Smith, M. Mitchell Smith, Tashima E. Lambert, Ann L. Beyer, Sarah L. French, Martha L. Sikes, Yvonne N. Osheim
Publikováno v:
French, S L, Sikes, M L, Hontz, R D, Osheim, Y N, Lambert, T E, El Hage, A, Smith, M M, Tollervey, D, Smith, J S & Beyer, A L 2011, ' Distinguishing the Roles of Topoisomerases I and II in Relief of Transcription-Induced Torsional Stress in Yeast rRNA Genes ', Molecular and Cellular Biology, vol. 31, no. 3, pp. 482-494 . https://doi.org/10.1128/MCB.00589-10
To better understand the role of topoisomerase activity in relieving transcription-induced supercoiling, yeast genes encoding rRNA were visualized in cells deficient for either or both of the two major topoisomerases. In the absence of both topoisome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b4e1371892ccafbdddf262b184008dc
https://doi.org/10.1128/mcb.00589-10
https://doi.org/10.1128/mcb.00589-10
Autor:
Michael P. Rout, Marlene Oeffinger, Angelica Ferguson, David Tollervey, Daniel Zenklusen, Robert H. Singer, Brian T. Chait, Aziz El Hage, Karen E Wei
Publikováno v:
Oeffinger, M, Zenklusen, D, Ferguson, A, Wei, K E, El Hage, A, Tollervey, D, Chait, B T, Singer, R H & Rout, M P 2009, ' Rrp17p Is a Eukaryotic Exonuclease Required for 5 ' End Processing of Pre-60S Ribosomal RNA ', Molecular Cell, vol. 36, no. 5, pp. 768-781 . https://doi.org/10.1016/j.molcel.2009.11.011
Molecular Cell
Molecular Cell
Summary Ribosomal processing requires a series of endo- and exonucleolytic steps for the production of mature ribosomes, of which most have been described. To ensure ribosome synthesis, 3′ end formation of rRNA uses multiple nucleases acting in par
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57ba4fc041e144933e0c6d2811d917bf
Trf4 targets ncRNAs from telomeric and rDNA spacer regions and functions in rDNA copy number control
Publikováno v:
The EMBO Journal
Houseley, J, Kotovic, K, El Hage, A & Tollervey, D 2007, ' Trf4 targets ncRNAs from telomeric and rDNA spacer regions and functions in rDNA copy number control ', EMBO Journal, vol. 26, no. 24, pp. 4996-5006 . https://doi.org/10.1038/sj.emboj.7601921
Houseley, J, Kotovic, K, El Hage, A & Tollervey, D 2007, ' Trf4 targets ncRNAs from telomeric and rDNA spacer regions and functions in rDNA copy number control ', EMBO Journal, vol. 26, no. 24, pp. 4996-5006 . https://doi.org/10.1038/sj.emboj.7601921
Trf4 is the poly(A) polymerase component of TRAMP4, which stimulates nuclear RNA degradation by the exosome. We report that in Saccharomyces cerevisiae strains lacking Trf4, cryptic transcripts are detected from regions of repressed chromatin at telo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fdffe6efd67908282eb354fcc311448
http://europepmc.org/articles/PMC2080816
http://europepmc.org/articles/PMC2080816
Autor:
Jean-Hervé Alix, Aziz El Hage
Publikováno v:
Molecular Microbiology. 51:189-201
Escherichia coli dnaK-ts mutants are defective in the late stages of ribosome biogenesis at high temperature. Here, we show that the 21S, 32S and 45S ribosomal particles that accumulate in the dnaK756-ts mutant at 44 degrees C contain unprocessed for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5acd2baf70ec2aa0448b3c6cdaf37977
https://doi.org/10.1046/j.1365-2958.2003.03813.x
https://doi.org/10.1046/j.1365-2958.2003.03813.x
Publikováno v:
El Hage, A, Webb, S, Kerr, A & Tollervey, D 2014, ' Genome-Wide Distribution of RNA-DNA Hybrids Identifies RNase H Targets in tRNA Genes, Retrotransposons and Mitochondria ', PLoS Genetics, vol. 10, no. 10, e1004716 . https://doi.org/10.1371/journal.pgen.1004716
PLoS Genetics
PLoS Genetics, Vol 10, Iss 10, p e1004716 (2014)
PLoS Genetics
PLoS Genetics, Vol 10, Iss 10, p e1004716 (2014)
During transcription, the nascent RNA can invade the DNA template, forming extended RNA-DNA duplexes (R-loops). Here we employ ChIP-seq in strains expressing or lacking RNase H to map targets of RNase H activity throughout the budding yeast genome. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f2dd24ac2c3ac5b7259b0353603bb62
https://hdl.handle.net/20.500.11820/c39a316e-d7bf-4244-9b19-13f7a3d528ad
https://hdl.handle.net/20.500.11820/c39a316e-d7bf-4244-9b19-13f7a3d528ad