Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Azita Rasti"'
Autor:
Cristina Parrado Fernandez, Sanja Juric, Maria Backlund, Märta Dahlström, Nather Madjid, Veronica Lidell, Azita Rasti, Johan Sandin, Gunnar Nordvall, Pontus Forsell
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 13, p 11159 (2023)
The introduction of anti-amyloid monoclonal antibodies against Alzheimer’s disease (AD) is of high importance. However, even though treated patients show very little amyloid pathology, there is only a modest effect on the rate of cognitive decline.
Externí odkaz:
https://doaj.org/article/58941829f36842439f2258929c51ee8b
Autor:
Sean G Rudd, Nikolaos Tsesmetzis, Kumar Sanjiv, Cynthia BJ Paulin, Lakshmi Sandhow, Juliane Kutzner, Ida Hed Myrberg, Sarah S Bunten, Hanna Axelsson, Si Min Zhang, Azita Rasti, Petri Mäkelä, Si'Ana A Coggins, Sijia Tao, Sharda Suman, Rui M Branca, Georgios Mermelekas, Elisée Wiita, Sun Lee, Julian Walfridsson, Raymond F Schinazi, Baek Kim, Janne Lehtiö, Georgios Z Rassidakis, Katja Pokrovskaja Tamm, Ulrika Warpman‐Berglund, Mats Heyman, Dan Grandér, Sören Lehmann, Thomas Lundbäck, Hong Qian, Jan‐Inge Henter, Torsten Schaller, Thomas Helleday, Nikolas Herold
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 3, Pp n/a-n/a (2020)
Abstract The deoxycytidine analogue cytarabine (ara‐C) remains the backbone treatment of acute myeloid leukaemia (AML) as well as other haematological and lymphoid malignancies, but must be combined with other chemotherapeutics to achieve cure. Yet
Externí odkaz:
https://doaj.org/article/ee94cd1a0d794c99b66c9335300d2f1e
Autor:
Xiangwei Hua, Kumar Sanjiv, Helge Gad, Therese Pham, Camilla Gokturk, Azita Rasti, Zhenjun Zhao, Kang He, Mingxuan Feng, Yunjin Zang, Jianjun Zhang, Qiang Xia, Thomas Helleday, Ulrika Warpman Berglund
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 11 (2019)
Background: Hepatocellular carcinoma (HCC) is the most common form of liver cancer and is generally caused by viral infections or consumption of mutagens, such as alcohol. While liver transplantation and hepatectomy is curative for some patients, man
Externí odkaz:
https://doaj.org/article/ea44fe1660bc4ebd9bd694a45f0ab9ba
Autor:
Forsell, Cristina Parrado Fernandez, Sanja Juric, Maria Backlund, Märta Dahlström, Nather Madjid, Veronica Lidell, Azita Rasti, Johan Sandin, Gunnar Nordvall, Pontus
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 13; Pages: 11159
The introduction of anti-amyloid monoclonal antibodies against Alzheimer’s disease (AD) is of high importance. However, even though treated patients show very little amyloid pathology, there is only a modest effect on the rate of cognitive decline.
Autor:
Maurice Michel, Carlos Benítez-Buelga, Patricia A. Calvo, Bishoy M. F. Hanna, Oliver Mortusewicz, Geoffrey Masuyer, Jonathan Davies, Olov Wallner, Kumar Sanjiv, Julian J. Albers, Sergio Castañeda-Zegarra, Ann-Sofie Jemth, Torkild Visnes, Ana Sastre-Perona, Akhilesh N. Danda, Evert J. Homan, Karthick Marimuthu, Zhao Zhenjun, Celestine N. Chi, Antonio Sarno, Elisée Wiita, Catharina von Nicolai, Anna J. Komor, Varshni Rajagopal, Sarah Müller, Emily C. Hank, Marek Varga, Emma R. Scaletti, Monica Pandey, Stella Karsten, Hanne Haslene-Hox, Simon Loevenich, Petra Marttila, Azita Rasti, Kirill Mamonov, Florian Ortis, Fritz Schömberg, Olga Loseva, Josephine Stewart, Nicholas D’Arcy-Evans, Tobias Koolmeister, Martin Henriksson, Dana Michel, Ana de Ory, Lucia Acero, Oriol Calvete, Martin Scobie, Christian Hertweck, Ivan Vilotijevic, Christina Kalderén, Ana Osorio, Rosario Perona, Alexandra Stolz, Pål Stenmark, Ulrika Warpman Berglund, Miguel de Vega, Thomas Helleday
Publikováno v:
Science. 376:1471-1476
Oxidative DNA damage is recognized by 8-oxoguanine (8-oxoG) DNA glycosylase 1 (OGG1), which excises 8-oxoG, leaving a substrate for apurinic endonuclease 1 (APE1) and initiating repair. Here, we describe a small molecule (TH10785) that interacts with
Autor:
Ulrika Warpman Berglund, Thomas Helleday, Julian Walfridsson, Päivi Östling, Mathew J. Garnett, Kim Theilgaard-Mönch, Sören Lehmann, Teresa Sandvall, Olov Wallner, Martin Henriksson, Tobias Koolmeister, Martin Scobie, Torkild Visnes, Nona Struyf, Thea Kristin Våtsveen, Montserrat Estruch, Anders Centio, Stefanie Friedrich, Azita Rasti, Camilla Göktürk, Elisee Wiita, Helge Gad, Akhilesh Nagesh Danda, Brinton Seashore-Ludlow, Yaser Heshmati, Andreas Höglund, Ingrid Almlöf, Viktoriia Tsuber, Tom Erkers, Therese M. Pham, José Manuel Calderón-Montaño, Kumar Sanjiv
Supplementary figures and tables and material and methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1280d78da8fe2c0fa692e2c21f2cc0ef
https://doi.org/10.1158/0008-5472.22490525
https://doi.org/10.1158/0008-5472.22490525
Autor:
Ulrika Warpman Berglund, Thomas Helleday, Julian Walfridsson, Päivi Östling, Mathew J. Garnett, Kim Theilgaard-Mönch, Sören Lehmann, Teresa Sandvall, Olov Wallner, Martin Henriksson, Tobias Koolmeister, Martin Scobie, Torkild Visnes, Nona Struyf, Thea Kristin Våtsveen, Montserrat Estruch, Anders Centio, Stefanie Friedrich, Azita Rasti, Camilla Göktürk, Elisee Wiita, Helge Gad, Akhilesh Nagesh Danda, Brinton Seashore-Ludlow, Yaser Heshmati, Andreas Höglund, Ingrid Almlöf, Viktoriia Tsuber, Tom Erkers, Therese M. Pham, José Manuel Calderón-Montaño, Kumar Sanjiv
Acute myeloid leukemia (AML) is an aggressive hematologic malignancy, exhibiting high levels of reactive oxygen species (ROS). ROS levels have been suggested to drive leukemogenesis and is thus a potential novel target for treating AML. MTH1 prevents
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cc3a2e4a790d48cfedb4902184be996
https://doi.org/10.1158/0008-5472.c.6533174.v1
https://doi.org/10.1158/0008-5472.c.6533174.v1
Autor:
Nadilly Bonagas, Nina M. S. Gustafsson, Martin Henriksson, Petra Marttila, Robert Gustafsson, Elisée Wiita, Sanjay Borhade, Alanna C. Green, Karl S. A. Vallin, Antonio Sarno, Richard Svensson, Camilla Göktürk, Therese Pham, Ann-Sofie Jemth, Olga Loseva, Victoria Cookson, Nicole Kiweler, Lars Sandberg, Azita Rasti, Judith E. Unterlass, Martin Haraldsson, Yasmin Andersson, Emma R. Scaletti, Christoffer Bengtsson, Cynthia B. J. Paulin, Kumar Sanjiv, Eldar Abdurakhmanov, Linda Pudelko, Ben Kunz, Matthieu Desroses, Petar Iliev, Katarina Färnegårdh, Andreas Krämer, Neeraj Garg, Maurice Michel, Sara Häggblad, Malin Jarvius, Christina Kalderén, Amanda Bögedahl Jensen, Ingrid Almlöf, Stella Karsten, Si Min Zhang, Maria Häggblad, Anders Eriksson, Jianping Liu, Björn Glinghammar, Natalia Nekhotiaeva, Fredrik Klingegård, Tobias Koolmeister, Ulf Martens, Sabin Llona-Minguez, Ruth Moulson, Helena Nordström, Vendela Parrow, Leif Dahllund, Birger Sjöberg, Irene L. Vargas, Duy Duc Vo, Johan Wannberg, Stefan Knapp, Hans E. Krokan, Per I. Arvidsson, Martin Scobie, Johannes Meiser, Pål Stenmark, Ulrika Warpman Berglund, Evert J. Homan, Thomas Helleday
Publikováno v:
Nature Cancer
The folate metabolism enzyme MTHFD2 (methylenetetrahydrofolate dehydrogenase/cyclohydrolase) is consistently overexpressed in cancer but its roles are not fully characterized, and current candidate inhibitors have limited potency for clinical develop
Autor:
Nicholas C.K. Valerie, Kumar Sanjiv, Oliver Mortusewicz, Si Min Zhang, Azita Rasti, Marie-France Langelier, Daniel Rehling, Adam Throup, Matthieu Desroses, Prasad Wakchaure, Ingrid Almlöf, Seher Alam, Johan Boström, Luka Bevc, Pål Stenmark, John M. Pascal, Thomas Helleday, Brent D.G. Page, Mikael Altun
Cellular target engagement technologies are reforming drug discovery by enabling quantification of intracellular drug binding; however, concomitant assessment of drug-associated phenotypes has proven challenging. We have developed cellular target eng
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f650866e5c8606bb3761b58216ad109
https://doi.org/10.1101/2022.09.19.505646
https://doi.org/10.1101/2022.09.19.505646
Autor:
Nadilly Bonagas, Nina Gustafsson, Martin Henriksson, Petra Marttila, Robert Gustafsson, Elisée Wiita, Sanjay Borhade, Alanna Green, Karl Vallin, Antonio Sarno, Richard Svensson, Camilla Göktürk, Therese Pham, Ann-Sofie Jemth, Olga Loseva, Victoria Cookson, Nicole Kiweler, Lars Sandberg, Azita Rasti, Judith Unterlass, Martin Haraldsson, Yasmin Andersson, Emma Scaletti, Christoffer Bengtsson, Cynthia Paulin, Kumar Sanjiv, Eldar Abdurakhmanov, Linda Pudelko, Ben Kunz, Matthieu Desroses, Petar Iliev, Katarina Färnegårdh, Andreas Krämer, Neeraj Garg, Maurice Michel, Sara Häggblad, Malin Jarvius, Christina Kalderén, Amanda Bögedahl Jensen, Ingrid Almlöf, Stella Karsten, Si Min Zhang, Maria Häggblad, Anders Eriksson, Jianping Liu, Björn Glinghammar, Natalia Nekhotiaeva, Fredrik Klingegård, Tobias Koolmeister, Ulf Martens, Sabin Llona-Minguez, Ruth Moulson, Helena Nordström, Vendela Parrow, Leif Dahllund, Birger Sjöberg, Irene Vargas, Duy Duc Vo, Johan Wannberg, Stefan Knapp, Hans Krokan, Per Arvidsson, Martin Scobie, Johannes Meiser, Pål Stenmark, Ulrika Warpman Berglund, Evert Homan, Thomas Helleday
Supplementary methods for the article "Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress".
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::032514cb5181fdda8fdfefd73848c5d0
https://doi.org/10.21203/rs.3.pex-1730/v1
https://doi.org/10.21203/rs.3.pex-1730/v1