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Results of a curtailed randomized controlled trial, evaluating the efficacy and safety of azimilide in patients with implantable cardioverter-defibrillators: The SHIELD-2 trial

Autor: David B. Bharucha, Paul Dorian, Victoria M. Robinson, Kenneth W. Mahaffey, Peter R. Kowey

Publikováno v: American Heart Journal. 185:43-51

BACKGROUND: Frequent hospital attendances in patients with implantable cardioverter-defibrillators (ICDs) result in significant morbidity and health care costs. Current drugs to reduce ICD shocks and hospital visits have limited efficacy and consider

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Anti-arrhythmic drug therapy in implantable cardioverter-defibrillator recipients

Autor: Vidal Essebag, Prithwish Banerjee, Vincenzo Russo, Riccardo Proietti, Ahmed AlTurki, Tarvinder Dhanjal

Implantable cardioverter-defibrillators (ICDs) have revolutionized the primary and secondary prevention of patients with ventricular arrhythmias. However, the adverse effects of appropriate or inappropriate shocks may require the adjunctive use of an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::107e2bdff331128c203ebfe8f8dd526f
http://hdl.handle.net/11577/3300164

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Azimilide Reduces Emergency Department Visits and Hospitalizations in Patients With an Implantable Cardioverter-Defibrillator in a Placebo-Controlled Clinical Trial

Autor: Peter R. Kowey, Paul Dorian, Craig M. Pratt, Stefan H. Hohnloser, Jose Brum, Preston Dunnmon, Hussein R. Al-Khalidi, Michael J. Holroyde

Publikováno v: Journal of the American College of Cardiology. 52(13):1076-1083

ObjectivesThe goal of this study was to determine whether azimilide, as compared with placebo, will reduce the number of emergency department (ED) visits and hospitalizations caused by arrhythmias or cardiac events in patients with an implantable car

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Electrophysiological effects of azimilide in an in vitro model of simulated-ischemia and reperfusion in guinea-pig ventricular myocardium

Autor: Pierre Ducouret, Laurent Sallé, Joffrey Ducroq, Clément Tabourel, René Rouet, Paolo Emilio Puddu, Jean-Louis Gérard

Publikováno v: European Journal of Pharmacology. 518:165-174

There are few investigations on azimilide effects during ischemia/reperfusion. We have therefore investigated low concentrations of azimilide (0.1 and 0.5 micromol/l) versus Controls on action potential parameters and occurrence of repetitive respons

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https://doi.org/10.1016/j.ejphar.2005.06.014

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Azimilide dihydrochloride: a new class III anti-arrhythmic agent

Autor: Rajjit Abrol, Richard L. Page

Publikováno v: Expert Opinion on Investigational Drugs. 9:2705-2715

Azimilide dihydrochloride (Stedicor) is a new class III anti-arrhythmic agent that is being developed by ProctorGamble to treat supraventricular and ventricular arrhythmias. Development of this agent is being undertaken due to the high prevalence of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2141d719377f54e81d2b92e5212c9496
https://doi.org/10.1517/13543784.9.11.2705

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Role of Antiarrhythmic Drugs: Frequent Implantable Cardioverter-Defibrillator Shocks, Risk of Proarrhythmia, and New Drug Therapy

Autor: Gan-Xin Yan, Peter R. Kowey, Christopher Droogan, Chinmay Patel

Publikováno v: Heart Failure Clinics. 7:195-205

The implantable cardioverter-defibrillator (ICD) is the standard of care in patients with ischemic and nonischemic cardiomyopathy who are at high risk for arrhythmic events and sudden cardiac death. Although an ICD saves life, ICD shocks are emotiona

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https://doi.org/10.1016/j.hfc.2010.12.003

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Effects of Berberine Derivate CPU 86017 on IKur Currents and Experimental Atrial Fibrillation

Autor: Xiang Guo, Yue-Miao Yin, Chun-Lin Chen, Yi-Qun Tang, De-Zai Dai, Minhui Wang, Shu-Juan Sun

Publikováno v: Chinese Journal of Natural Medicines. 8:212-217

Aim Compared with azimilide, the present study was designed to observe the anti-atrial fibrillation (AF) effects of CPU 86017, a berberine derivative, and explore its possible ion-channel mechanism. Methods The effects of CPU 86017 on ultra-rapid del

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https://doi.org/10.3724/sp.j.1009.2010.00212

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Inhibitory Effect of Azimilide on Na+/Ca2+ Exchange Current in Guinea-Pig Cardiac Myocytes

Autor: Junko Kimura, Yasuhide Watanabe

Publikováno v: Journal of Pharmacological Sciences, Vol 114, Iss 1, Pp 111-114 (2010)

We examined the effect of azimilide, a class III antiarrhythmic drug, on Na+/Ca2+ exchange current (INCX) in guinea-pig cardiac single ventricular cells. External application of azimilide suppressed bi-directional INCX in a concentration-dependent ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c10c232d05efc0dae4ac3ff0051d7c0d
http://www.sciencedirect.com/science/article/pii/S1347861319308874

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