Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Azimic acid"'
Publikováno v:
Tetrahedron: Asymmetry. 20:1181-1184
Herein we report a concise enantioselective synthesis of (+)-azimic acid starting from (5S,6S)-6-methyl-5-benzyloxy-2-piperidinone 8a, which was prepared from protected (S)-3-hydroxyglutarimide 6 according to a method recently disclosed in our labora
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a649835f28d3a92c8f7be9e43b52fb2
https://doi.org/10.1016/j.tetasy.2009.04.008
https://doi.org/10.1016/j.tetasy.2009.04.008
Publikováno v:
Organic Letters. 5:3839-3842
[reaction: see text] The enantioselective total syntheses of (+)-azimine and (+)-carpaine have been developed, starting with (S)-1,2,4-butanetriol as a single source of chirality. The key common feature in these syntheses involves stereoselective int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::928e9fda8e4813e85efcdacb7e497201
https://doi.org/10.1021/ol030088w
https://doi.org/10.1021/ol030088w
Autor:
Apurba Datta, Kothakonda Kiran Kumar
Publikováno v:
Tetrahedron. 55:13899-13906
An efficient synthesis of enantiopure (+)-azimic acid has been developed, utilizing easily available amino acid L-alanine as a chiral pool starting material.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cdab8bf881a68051ea95d385a5907724
https://doi.org/10.1016/s0040-4020(99)00848-0
https://doi.org/10.1016/s0040-4020(99)00848-0
Publikováno v:
Tetrahedron. 54:15589-15606
A combination of 1, 3-dipolar cycloaddition of Z-nitrones to the chiral dipolarophile and subsequent ring transformation of the resulting adducts to the piperidinols has provided a new practical synthesis of 2, 6-disubstituted 3-piperidinol alkaloids
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17d78ee17ad6358e778acda0b31ea8ba
https://doi.org/10.1016/s0040-4020(98)01012-6
https://doi.org/10.1016/s0040-4020(98)01012-6
Autor:
Zhi-Hui Lu, Wei-Shan Zhou
Publikováno v:
Tetrahedron. 49:4659-4664
A new concise stereoselective total synthesis of (+)-azimic acid, which is the immediate precursor of macrocyclic dilactone azimine, has been achieved in eleven steps from (2S,6S)-6-hydroxy-2-methyl-N-tosyl-Δ4-piperidone-3 (5) with a high overall yi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6530e884e05165c8b698a1004a64b401
https://doi.org/10.1016/s0040-4020(01)81294-1
https://doi.org/10.1016/s0040-4020(01)81294-1
Autor:
Wei-Shan Zhou, Zhi-Hui Lu
Publikováno v:
ChemInform. 24
A new concise stereoselective total synthesis of (+)-azimic acid, which is the immediate precursor of macrocyclic dilactone azimine, has been achieved in eleven steps from (2S,6S)-6-hydroxy-2-methyl-N-tosyl-Δ4-piperidone-3 (5) with a high overall yi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c0bc17cdefcae43ca9ad8e64598badd
https://doi.org/10.1002/chin.199341277
https://doi.org/10.1002/chin.199341277
Publikováno v:
ChemInform. 27
A combination of 1, 3-dipolar cycloaddition of Z-nitrone (2) to the chiral dipolarophile (3) and subsequent ring transformation of the resulting adducts (4 and 6) to piperidinol (17) has provided a new practical synthesis of 2, 3, 6-trisubstituted pi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93e842ae405e05761115bce4b9f7cf61
https://doi.org/10.1002/chin.199647231
https://doi.org/10.1002/chin.199647231
Publikováno v:
ChemInform. 30
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb732b6fbfb1e3ce86c99ec6e61eaf61
https://doi.org/10.1002/chin.199918202
https://doi.org/10.1002/chin.199918202
Autor:
Kothakonda Kiran Kumar, Apurba Datta
Publikováno v:
ChemInform. 31
An efficient synthesis of enantiopure (+)-azimic acid has been developed, utilizing easily available amino acid L-alanine as a chiral pool starting material.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93b87db11c19e0e6094e480938ee92cf
https://doi.org/10.1002/chin.200009203
https://doi.org/10.1002/chin.200009203
Publikováno v:
ChemInform. 34
Reduction of the enantiopure β-amino esters 10 provides the γ-amnio alcohol 11, which is condensed with 2,4-pentadione to afford 12. Stepwise cyclization of 12 produced the cyclic enamine 13, which is hydrogenated to deliver all cis-2,3,6-trisubsti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8379b56ce75228c3661e74d4566e62b9
https://doi.org/10.1002/chin.200333204
https://doi.org/10.1002/chin.200333204