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Akademický článek

Targeting DNA damage repair mechanism by using RAD50-silencing siRNA nanoparticles to enhance radiotherapy in triple negative breast cancer

Autor: Abdulmottaleb E. Zetrini, Azhar Z. Abbasi, Chunsheng He, HoYin Lip, Ibrahim Alradwan, Andrew M. Rauth, Jeffrey T. Henderson, Xiao Yu Wu

Publikováno v: Materials Today Bio, Vol 28, Iss , Pp 101206- (2024)

Radiotherapy (RT) is one of major therapeutic modalities in combating breast cancer. In RT, ionizing radiation is employed to induce DNA double-strand breaks (DSBs) as a primary mechanism that causes cancer cell death. However, the induced DNA damage

Externí odkaz: https://doaj.org/article/a1dd332717db491980efe1b81f3e2f43

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Akademický článek

Biocompatible and bioactivable terpolymer-lipid-MnO2 Nanoparticle-based MRI contrast agent for improving tumor detection and delineation

Autor: Tin-Yo C. Yen, Azhar Z. Abbasi, Chungsheng He, Ho-Yin Lip, Elliya Park, Mohammad A. Amini, Hibret A. Adissu, Warren Foltz, Andrew M. Rauth, Jeffrey Henderson, Xiao Yu Wu

Publikováno v: Materials Today Bio, Vol 25, Iss , Pp 100954- (2024)

Early and precise detection of solid tumor cancers is critical for improving therapeutic outcomes. In this regard, magnetic resonance imaging (MRI) has become a useful tool for tumor diagnosis and image-guided therapy. However, its effectiveness is l

Externí odkaz: https://doaj.org/article/e33623b17de342aa9ae9a5225a2f51c7

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Akademický článek

Brain‐Penetrating and Disease Site‐Targeting Manganese Dioxide‐Polymer‐Lipid Hybrid Nanoparticles Remodel Microenvironment of Alzheimer's Disease by Regulating Multiple Pathological Pathways

Autor: Elliya Park, Lily Yi Li, Chunsheng He, Azhar Z. Abbasi, Taksim Ahmed, Warren D. Foltz, Regan O'Flaherty, Maham Zain, Robert P. Bonin, Andrew M. Rauth, Paul E. Fraser, Jeffrey T. Henderson, Xiao Yu Wu

Publikováno v: Advanced Science, Vol 10, Iss 12, Pp n/a-n/a (2023)

Abstract Finding effective disease‐modifying treatment for Alzheimer's disease remains challenging due to an array of factors contributing to the loss of neural function. The current study demonstrates a new strategy, using multitargeted bioactive

Externí odkaz: https://doaj.org/article/00664533c62e4fa0a99ec8433353bc08

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Akademický článek

Remodeling Tumor Immune Microenvironment by Using Polymer-Lipid-Manganese Dioxide Nanoparticles with Radiation Therapy to Boost Immune Response of Castration-Resistant Prostate Cancer

Autor: Abdulmottaleb E. Zetrini, HoYin Lip, Azhar Z. Abbasi, Ibrahim Alradwan, Taksim Ahmed, Chunsheng He, Jeffrey T. Henderson, Andrew M. Rauth, Xiao Yu Wu

Publikováno v: Research, Vol 6 (2023)

Despite substantial progress in the treatment of castration-resistant prostate cancer (CRPC), including radiation therapy and immunotherapy alone or in combination, the response to treatment remains poor due to the hypoxic and immunosuppressive natur

Externí odkaz: https://doaj.org/article/3768f06c7e5c44c0bc4140403e9cb270

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Akademický článek

Oxidation levels of North American over-the-counter n-3 (omega-3) supplements and the influence of supplement formulation and delivery form on evaluating oxidative safety

Autor: Stefan A. Jackowski, Azhar Z. Alvi, Abdur Mirajkar, Zahabia Imani, Yuliya Gamalevych, Nisar A. Shaikh, George Jackowski

Publikováno v: Journal of Nutritional Science, Vol 4 (2015)

The aim of the present study was to evaluate the oxidation status of North American n-3 (omega-3) PUFA nutritional supplements commercially available in Canada and evaluate the influence of product formulation and delivery form on oxidative safety. A

Externí odkaz: https://doaj.org/article/df19d34cd1d64083829ad63a1837ffdd

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