Risk assessment and transmission of fluoroquinolone resistance in drug-resistant pulmonary tuberculosis: a retrospective genomic epidemiology study

Autor: Vijayalakshmi Jawaharlal Nehru, Maria Jose Vandakunnel, Usharani Brammacharry, Venkateswari Ramachandra, Gunavathy Pradhabane, Balasundaram Revathi Mani, Azger Dusthackeer VN, Muthuraj Muthaiah

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)

Abstract Fluoroquinolone resistance is a major challenge in treating Multidrug-Resistant Tuberculosis globally. The GenoType MTBDRsl Ver 2.0, endorsed by the WHO, was used to characterize fluoroquinolone resistance. The fluoroquinolone resistance rat

Externí odkaz: https://doaj.org/article/279d15a4fa174c7bb54b336ed699a248

Risk assessment and transmission of fluoroquinolone resistance in drug-resistant pulmonary tuberculosis: a retrospective genomic epidemiology study.

Autor: Nehru, Vijayalakshmi Jawaharlal, Jose Vandakunnel, Maria, Brammacharry, Usharani, Ramachandra, Venkateswari, Pradhabane, Gunavathy, Mani, Balasundaram Revathi, VN, Azger Dusthackeer, Muthaiah, Muthuraj

Publikováno v: Scientific Reports; 8/24/2024, Vol. 14 Issue 1, p1-10, 10p

3,5-disubstituted pyridines with potent activity against drug-resistant Mycobacterium tuberculosis clinical isolates.

Autor: Sangu KG; Department of Natural Products & Medicinal Chemistry, CSIR - Indian Institute of Chemical Technology, Tarnaka, Hyderabad, 500 007, India.; Academy of Scientific & Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, 201 002, India., Azger Dusthackeer VN; Department of Bacteriology, National Institute for Research in Tuberculosis, Chennai, 600 031, India., Singh VK; Department of Natural Products & Medicinal Chemistry, CSIR - Indian Institute of Chemical Technology, Tarnaka, Hyderabad, 500 007, India., Maykalwar S; Department of Natural Products & Medicinal Chemistry, CSIR - Indian Institute of Chemical Technology, Tarnaka, Hyderabad, 500 007, India.; Academy of Scientific & Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, 201 002, India., Krishna EV; Academy of Scientific & Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, 201 002, India.; Department of Applied Biology, CSIR - Indian Institute of Chemical Technology, Tarnaka, Hyderabad, 500 007, India., Angayarkanni B; Department of Bacteriology, National Institute for Research in Tuberculosis, Chennai, 600 031, India., Maitra R; Department of Molecular Microbiology & Immunology, CSIR - Central Drug Research Institute, Sitapur Road, Janakipuram Extension, Lucknow, Uttar Pradesh, 226 031, India., Chopra S; Academy of Scientific & Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, 201 002, India.; Department of Molecular Microbiology & Immunology, CSIR - Central Drug Research Institute, Sitapur Road, Janakipuram Extension, Lucknow, Uttar Pradesh, 226 031, India., Misra S; Academy of Scientific & Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, 201 002, India.; Department of Applied Biology, CSIR - Indian Institute of Chemical Technology, Tarnaka, Hyderabad, 500 007, India., Rode HB; Department of Natural Products & Medicinal Chemistry, CSIR - Indian Institute of Chemical Technology, Tarnaka, Hyderabad, 500 007, India.; Academy of Scientific & Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, 201 002, India.

Publikováno v: Future medicinal chemistry [Future Med Chem] 2024 Oct 03, pp. 1-19. Date of Electronic Publication: 2024 Oct 03.

Insights on recent approaches in drug discovery strategies and untapped drug targets against drug resistance

Autor: Ramalingam Peraman, Sathish Kumar Sure, V. N. Azger Dusthackeer, Naresh Babu Chilamakuru, Padmanabha Reddy Yiragamreddy, Chiranjeevi Pokuri, Vinay Kumar Kutagulla, Santhivardhan Chinni

Publikováno v: Future Journal of Pharmaceutical Sciences, Vol 7, Iss 1, Pp 1-25 (2021)

Abstract Background Despite the various strategies undertaken in the clinical practice, the mortality rate due to antibiotic-resistant microbes has been markedly increasing worldwide. In addition to multidrug-resistant (MDR) microbes, the “ESKAPE�

Externí odkaz: https://doaj.org/article/c4c5d80db2a2449cb0d477fc3a6e0e11

Discovery of a highly potent novel rifampicin analog by preparing a hybrid of the precursors of the antibiotic drugs rifampicin and clofazimine

Autor: Pasupathy Saravanan, V. N. Azger Dusthackeer, R. S. Rajmani, B. Mahizhaveni, Christy R. Nirmal, Sam Ebenezer Rajadas, Neerupma Bhardwaj, C. Ponnuraja, Adhin Bhaskar, A. K. Hemanthkumar, Geetha Ramachandran, Srikanth P. Tripathy

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)

Abstract Tuberculosis (TB) is an infectious disease caused by the bacillus Mycobacterium tuberculosis (Mtb). The present work reports the design and synthesis of a hybrid of the precursors of rifampicin and clofazimine, which led to the discovery of

Externí odkaz: https://doaj.org/article/56b9adfff36d4fa4b354549045157315