Petasis/Diels–Alder/Cyclization Cascade Reactions for the Generation of Scaffolds with Multiple Stereogenic Centers and Orthogonal Handles for Library Production.

Autor: Flagstad, Thomas^1,2, Azevedo, Carlos M. G.^1,2, Min, Geanna^1,2, Willaume, Anthony³, Morgentin, Rémy³, Nielsen, Thomas E.^1,4,5 ten@sund.ku.dk, Clausen, Mads H.^1,2 mhc@kemi.dtu.dk

Publikováno v: European Journal of Organic Chemistry. 9/30/2018, Vol. 2018 Issue 36, p5023-5029. 7p.

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Generation of a Heteropolycyclic and sp3-Rich Scaffold for Library Synthesis from a Highly Diastereoselective Petasis/Diels–Alder and ROM–RCM Reaction Sequence

Autor: Flagstad, Thomas, Azevedo, Carlos M. G., Troelsen, Nikolaj S., Min, Geanna K., Macé, Yohan, Willaume, Anthony, Guilleux, Rachel, Velay, Mélanie, Bonnet, Karine, Morgentin, Remy, Nielsen, Thomas E., Clausen, Mads H.

Publikováno v: Flagstad, T, Azevedo, C M G, Troelsen, N S, Min, G K, Macé, Y, Willaume, A, Guilleux, R, Velay, M, Bonnet, K, Morgentin, R, Nielsen, T E & Clausen, M H 2019, ' Generation of a Heteropolycyclic and sp 3-Rich Scaffold for Library Synthesis from a Highly Diastereoselective Petasis/Diels–Alder and ROM–RCM Reaction Sequence ', European Journal of Organic Chemistry, vol. 2019, no. 5, pp. 1061-1076 . https://doi.org/10.1002/ejoc.201801551
Flagstad, T, Azevedo, C, Troelsen, N S, Min, G, Macé, Y, Willaume, A, Guilleux, R, Velay, M, Bonnet, K, Morgentin, R, Nielsen, T E & Clausen, M H 2019, ' Generation of a Heteropolycyclic and Sp 3-Rich Scaffold for Library Synthesis from a Highly Diastereoselective Petasis/DielsAlder and ROM-RCM Reaction Sequence ', European Journal of Organic Chemistry, vol. 2019, no. 5, pp. 1061-1076 . https://doi.org/10.1002/ejoc.201801551

Efficient access to diverse screening compounds with desirable, lead-like properties can be a bottleneck in early drug discovery and chemical biology. Herein we present an efficient, rapid route to three structurally distinct classes of compounds (A�

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https://curis.ku.dk/portal/da/publications/generation-of-a-heteropolycyclic-and-sp3rich-scaffold-for-library-synthesis-from-a-highly-diastereoselective-petasisdielsalder-and-romrcm-reaction-sequence(472ffe62-c777-4b1d-bb8c-9c609f3bbd36).html

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