Výsledky vyhledávání - "Azali Ahamada-Himidi"

Inhibition of secretory phospholipase A. 1-Design, synthesis and structure–activity relationship studies starting from 4-tetradecyloxybenzamidine to obtain specific inhibitors of group II sPLAs

Autor: Nadia Meddad-Bel Habich, Jean-Edouard Ombetta, Aazdine Lamouri, Françoise Heymans, Léon Assogba, Azali Ahamada-Himidi, Chang-Zhi Dong, Jean-Jacques Godfroid, Darina Aoun, Jack Huet, Latifa Boukli, Carine Mounier

Publikováno v: European Journal of Medicinal Chemistry. 40:850-861

Starting from 4-tetradecyloxybenzamidine ( PMS815 ), a non-specific inhibitor of GI and GII PLA 2 s, we report in this work the discovery of the specificity through design, synthesis and structure–activity relationships studies of different kinds o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::344bd152866c9acc1617d8c4905d47c3
https://doi.org/10.1016/j.ejmech.2005.03.027

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Molecular Modeling, Design, and Synthesis of Less Lipophilic Derivatives of 3-(4-Tetradecyloxybenzyl)-4H-1,2,4-oxadiazol-5-one (PMS1062) Specific for Group II Enzyme

Autor: Stéphanie Plocki, Darina Aoun, Azali Ahamada-Himidi, Fernanda Tavarès-Camarinha, Chang-Zhi Dong, France Massicot, Jack Huet, Sylvie Adolphe-Pierre, François Chau, Jean-Jacques Godfroid, Nohad Gresh, Jean Edouard Ombetta, Françoise Heymans

Publikováno v: European Journal of Organic Chemistry. 2005:2747-2757

3-(4-Tetradecyloxybenzyl)-4H-1,2,4-oxadiazol-5-one (PMS1062 or I) can probably act as a PLA2-II inhibitor on the acute inflammation model, but its highly lipophilic character could prevent it from being biodistributed effectively. In this work, based

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2907849bd2cff3ea49fcf945e4a99b0d
https://doi.org/10.1002/ejoc.200400541

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Inhibition of secretory phospholipase A2. 2-Synthesis and structure-activity relationship studies of 4,5-dihydro-3-(4-tetradecyloxybenzyl)-1,2,4-4H-oxadiazol-5-one (PMS1062) derivatives specific for group II enzyme

Autor: Chang-Zhi Dong, Azali Ahamada-Himidi, Stéphanie Plocki, Darina Aoun, Mohamed Touaibia, Nadia Meddad-Bel Habich, Jack Huet, Catherine Redeuilh, Jean-Edouard Ombetta, Jean-Jacques Godfroid, France Massicot, Françoise Heymans

Publikováno v: Bioorganicmedicinal chemistry. 13(6)

We have recently reported the discovery of a series of specific inhibitors of human group IIA phospholipase A2 (hGIIA PLA2) to display promising in vitro and in vivo properties. Here we describe the influence of different structural modifications on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbc2d4dbf8f1c4c30b4b98483d28af17
https://pubmed.ncbi.nlm.nih.gov/15727853

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Inhibition of secretory phospholipase A2. 1-design, synthesis and structure-activity relationship studies starting from 4-tetradecyloxybenzamidine to obtain specific inhibitors of group II sPLA2s

Autor: Léon, Assogba, Azali, Ahamada-Himidi, Nadia Meddad-Bel, Habich, Darina, Aoun, Latifa, Boukli, France, Massicot, Carine M, Mounier, Jack, Huet, Aazdine, Lamouri, Jean-Edouard, Ombetta, Jean-Jacques, Godfroid, Chang-Zhi, Dong, Françoise, Heymans

Publikováno v: European journal of medicinal chemistry. 40(9)

Starting from 4-tetradecyloxybenzamidine (PMS815), a non-specific inhibitor of GI and GII PLA2s, we report in this work the discovery of the specificity through design, synthesis and structure-activity relationships studies of different kinds of PMS8

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1edcdf0284fbf1f3b71ae814047d773b
https://pubmed.ncbi.nlm.nih.gov/16084626

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Akademický článek

Molecular Modeling, Design, and Synthesis of Less Lipophilic Derivatives of 3-(4-Tetradecyloxybenzyl)-4H-1,2,4-oxadiazol-5-one (PMS1062) Specific for Group II EnzymeInhibition of Secretory Phospholipases A2, 3. Part 2: C. Z. Dong et al., Bioorg. Med. Chem. 2005, 13, 19892007.

Autor: Stphanie Plocki, Darina Aoun, Azali Ahamada-Himidi, Fernanda Tavars-Camarinha, Chang-Zhi Dong, France Massicot, Jack Huet, Sylvie Adolphe-Pierre, Franois Chau, Jean-Jacques Godfroid, Nohad Gresh, Jean Edouard Ombetta, Franoise Heymans

Publikováno v: European Journal of Organic Chemistry; Jul2005, Vol. 2005 Issue 13, p2747-2757, 11p

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