Rapid erasure of hippocampal memory following inhibition of dentate gyrus granule cells

Autor: Noelia Madroñal, José M. Delgado-García, Azahara Fernández-Guizán, Jayanta Chatterjee, Maja Köhn, Camilla Mattucci, Apar Jain, Theodoros Tsetsenis, Anna Illarionova, Valery Grinevich, Cornelius T. Gross, Agnès Gruart

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)

Dentate gyrus (DG) is critical for memory formation in the hippocampus but its role in memory retrieval is unclear. Here, Gross and colleagues, show that granule cells in DG are not required for memory retrieval but for maintenance, and inhibiting th

Externí odkaz: https://doaj.org/article/13901a51755d460bbbcc7c6b45385d81

Expansion of NK cells and reduction of NKG2D expression in chronic lymphocytic leukemia. Correlation with progressive disease.

Autor: Leticia Huergo-Zapico, Andrea Acebes-Huerta, Ana Pilar Gonzalez-Rodriguez, Juan Contesti, Esther Gonzalez-García, Angel R Payer, Monica Villa-Alvarez, Azahara Fernández-Guizán, Alejandro López-Soto, Segundo Gonzalez

Publikováno v: PLoS ONE, Vol 9, Iss 10, p e108326 (2014)

The immune system may mediate anti-tumor responses in chronic lymphocytic leukemia (CLL) which may affect disease progression and survival. In this study, we analyzed the immune characteristics of 99 consecutive previously diagnosed CLL patients and

Externí odkaz: https://doaj.org/article/69ba20661a304827a80ee746d4ac0b53

Expression of ERp5 and GRP78 on the membrane of chronic lymphocytic leukemia cells: association with soluble MICA shedding

Autor: Ana P Gonzalez-Rodriguez, Juan Contesti, Segundo Gonzalez, Thomas Spies, Carlos López-Larrea, Andrea Acebes-Huerta, Veronika Groh, Azahara Fernández-Guizán, Juan R. de los Toyos, Esther G. González, Leticia Huergo-Zapico, Alejandro López-Soto

Publikováno v: Cancer Immunology, Immunotherapy. 61:1201-1210

MICA is a ligand of the activating receptor NKG2D, expressed by NK and T cells. MICA expression is induced in cancer cells favoring their elimination by the immune system; however, many advanced tumors shed soluble MICA (sMICA), which impairs NKG2D-m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f81f2e70c0f56fe18dffe4720420e168
https://doi.org/10.1007/s00262-011-1195-z

The activity of a novel mithramycin analog is related to its binding to DNA, cellular accumulation, and inhibition of Sp1-driven gene transcription

Autor: Sylvia Mansilla, Segundo Gonzalez, José Portugal, Francisco Morís, Luz Elena Núñez, Azahara Fernández-Guizán, Carolina Vizcaíno, Francisca Barceló

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

DIG-MSK (demycarosyl-3D-β-d-digitoxosyl-mithramycin SK) is a recently isolated compound of the mithramycin family of antitumor antibiotics, which includes mithramycin A (MTA) and mithramycin SK (MSK). Here, we present evidence that the binding of DI

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38ba60a283fc64f634ea1c74bdccec03
http://hdl.handle.net/10261/124432

Lenalidomide Induces Immunomodulation in Chronic Lymphocytic Leukemia and Enhances Antitumor Immune Responses Mediated by NK and CD4 T Cells

Autor: Segundo Gonzalez, Angel Ramirez Payer, Azahara Fernández-Guizán, Leticia Huergo-Zapico, Ana P Gonzalez-Rodriguez, Andrea Acebes-Huerta, Alejandro López-Soto

Publikováno v: BioMed Research International, Vol 2014 (2014)
Scopus
RUO. Repositorio Institucional de la Universidad de Oviedo
instname
BioMed Research International

Lenalidomide is an immunomodulatory drug with therapeutic activity in chronic lymphocytic leukemia (CLL). However, it has pleiotropic effects, and the mechanism of action responsible for its therapeutic activity has not been well defined yet. Herein,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2248ab248aa71a674957eb5abcaa984
https://doaj.org/article/e76001372e7846898ca6d75c09219f5e