Elucidating the mitochondrial proteome of Toxoplasma gondii reveals the presence of a divergent cytochrome c oxidase

Autor: Azadeh Seidi, Linden S Muellner-Wong, Esther Rajendran, Edwin T Tjhin, Laura F Dagley, Vincent YT Aw, Pierre Faou, Andrew I Webb, Christopher J Tonkin, Giel G van Dooren

Publikováno v: eLife, Vol 7 (2018)

The mitochondrion of apicomplexan parasites is critical for parasite survival, although the full complement of proteins that localize to this organelle has not been defined. Here we undertake two independent approaches to elucidate the mitochondrial

Externí odkaz: https://doaj.org/article/3594533da5ab4d4a81fd7f949f455500

A key cytosolic iron–sulfur cluster synthesis protein localizes to the mitochondrion of Toxoplasma gondii

Autor: Yi Tong Vincent Aw, Melanie Rug, F Victor Makota, Jenni A. Hayward, Azadeh Seidi, Jiwon Lee, Giel G. van Dooren

Publikováno v: Molecular Microbiology. 115:968-985

Iron-sulfur (Fe-S) clusters are prosthetic groups on proteins that function in a range of enzymatic and electron transfer reactions. Fe-S cluster synthesis is essential for the survival of all eukaryotes. Independent Fe-S cluster biosynthesis pathway

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d0942a2e588d6d387c001158cec6927
https://doi.org/10.1111/mmi.14651

Benchmarking single cell RNA-sequencing analysis pipelines using mixture control experiments

Autor: Luyi, Tian, Xueyi, Dong, Saskia, Freytag, Kim-Anh, Lê Cao, Shian, Su, Abolfazl, JalalAbadi, Daniela, Amann-Zalcenstein, Tom S, Weber, Azadeh, Seidi, Jafar S, Jabbari, Shalin H, Naik, Matthew E, Ritchie

Publikováno v: Nature methods. 16(6)

Single cell RNA-sequencing (scRNA-seq) technology has undergone rapid development in recent years, leading to an explosion in the number of tailored data analysis methods. However, the current lack of gold-standard benchmark datasets makes it difficu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4e7dbbadf16c6da01f92c87d9aaa265e
https://pubmed.ncbi.nlm.nih.gov/31133762

Identification of a divergent cytochrome c oxidase complex in the mitochondrial proteome of Toxoplasma gondii

Autor: Linden Muellner-Wong, Vincent Yt Aw, Erick T. Tjhin, Giel G. van Dooren, Christopher J. Tonkin, Andrew I. Webb, Azadeh Seidi, Laura F. Dagley, Esther Rajendran

The mitochondrion of apicomplexan parasites is critical for parasite survival, although the full complement of proteins that localize to this organelle has not been defined. Here we undertake two independent approaches to elucidate the mitochondrial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ab4f8865a0707381fb56305e4190af4
https://doi.org/10.1101/320184

Legionella pneumophila Strain 130b Evades Macrophage Cell Death Independent of the Effector SidF in the Absence of Flagellin

Autor: James E Vince, Qingqing Han, Gilu Abraham, Richard A. Flavell, Azadeh Seidi, Adam Vogrin, Seth L. Masters, Stéphane Hunot, Gerald W. Dorn, Mary Speir, Thomas Naderer

Publikováno v: Frontiers in Cellular and Infection Microbiology
Frontiers in Cellular and Infection Microbiology, 2017, 7, pp.35. ⟨10.3389/fcimb.2017.00035⟩
Frontiers in Cellular and Infection Microbiology, Frontiers, 2017, 7, pp.35. ⟨10.3389/fcimb.2017.00035⟩

International audience; The human pathogen Legionella pneumophila must evade host cell death signaling to enable replication in lung macrophages and to cause disease. After bacterial growth, however, L. pneumophila is thought to induce apoptosis duri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fa4e7bb08449462513a50ed675eaf61