Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Azadeh Khalili-Shirazi"'
Autor:
Madeleine Reilly, Iryna Benilova, Azadeh Khalili-Shirazi, Christian Schmidt, Parvin Ahmed, Daniel Yip, Parmjit S. Jat, John Collinge
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract There is an urgent need to develop disease-modifying therapies to treat neurodegenerative diseases which pose increasing challenges to global healthcare systems. Prion diseases, although rare, provide a paradigm to study neurodegenerative de
Externí odkaz:
https://doaj.org/article/6c3d427e537748449f547bcad8e6d4f9
Autor:
Simon Mead, Azadeh Khalili-Shirazi, Caroline Potter, Tzehow Mok, Akin Nihat, Harpreet Hyare, Stephanie Canning, Christian Schmidt, Tracy Campbell, Lee Darwent, Nicola Muirhead, Nicolette Ebsworth, Patrick Hextall, Madeleine Wakeling, Jacqueline Linehan, Vincenzo Libri, Bryan Williams, Zane Jaunmuktane, Sebastian Brandner, Peter Rudge, John Collinge
Publikováno v:
The Lancet Neurology. 21:342-354
Human prion diseases, including Creutzfeldt-Jakob disease (CJD), are rapidly progressive, invariably fatal neurodegenerative conditions with no effective therapies. Their pathogenesis involves the obligate recruitment of cellular prion protein (PrPWe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef45d09e5e880a72934907cbe6119c17
https://doi.org/10.1016/s1474-4422(22)00082-5
https://doi.org/10.1016/s1474-4422(22)00082-5
Publikováno v:
Biological psychiatry. 84(7)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b012a81ff1f599f34b755835e9f9907e
https://pubmed.ncbi.nlm.nih.gov/29752074
https://pubmed.ncbi.nlm.nih.gov/29752074
Autor:
Clare R. Trevitt, S. Samar Hasnain, Graham S. Jackson, Mark Batchelor, Sarah Cooper, Azadeh Khalili-Shirazi, Svetlana V. Antonyuk, T. Georgiou, Richard W. Strange, Samantha Jones, C. Fraser, Anthony R. Clarke, D. Sangar, John Collinge
Publikováno v:
Proceedings of the National Academy of Sciences. 106:2554-2558
Prion infection is characterized by the conversion of host cellular prion protein (PrP C ) into disease-related conformers (PrP Sc ) and can be arrested in vivo by passive immunization with anti-PrP monoclonal antibodies. Here, we show that the abili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0adb4546e17bbc1caebce9b0603496bb
https://doi.org/10.1073/pnas.0809170106
https://doi.org/10.1073/pnas.0809170106
Autor:
Sara Cohen-Krausz, Helen R. Saibil, MH Tattum, K Thumanu, Anthony R. Clarke, John Collinge, Azadeh Khalili-Shirazi, Elena V. Orlova, Graham S. Jackson, Christopher W. Wharton
Publikováno v:
Journal of Molecular Biology. 357:975-985
In prion diseases, the mammalian prion protein PrP is converted from a monomeric, mainly alpha-helical state into beta-rich amyloid fibrils. To examine the structure of the misfolded state, amyloid fibrils were grown from a beta form of recombinant m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82ee28c0d6e20db8be9ceb7c8fc3785d
https://doi.org/10.1016/j.jmb.2006.01.052
https://doi.org/10.1016/j.jmb.2006.01.052
Autor:
David J. Anstee, Gary Mallinson, Jacqueline M. Linehan, Linda Summers, Graham S. Jackson, Simon Hawke, Azadeh Khalili-Shirazi, John Collinge
Publikováno v:
Journal of General Virology. 86:2635-2644
Prion diseases involve conversion of host-encoded cellular prion protein (PrPC) to a disease-related isoform (PrPSc). Using recombinant humanβ-PrP, a panel of monoclonal antibodies was produced that efficiently immunoprecipitated native PrPScand rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d391e7440844784dbf9a0b7abc8a51b
https://doi.org/10.1099/vir.0.80375-0
https://doi.org/10.1099/vir.0.80375-0
Autor:
Anthony R. Clarke, John Collinge, Simon Hawke, Marco Londei, Azadeh Khalili-Shirazi, Graham S. Jackson, Sonia Quaratino, Linda Summers, Mourad Tayebi
Publikováno v:
The Journal of Immunology. 174:3256-3263
In prion diseases, such as variant Creutzfeldt-Jakob disease normal cellular prion protein (PrPC), a largely α-helical structure is converted to an abnormal conformational isoform (PrPSc) that shows an increase in β-sheet content. Similarly, the re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08de9d5eb26421f756108c4e5010b7c8
https://doi.org/10.4049/jimmunol.174.6.3256
https://doi.org/10.4049/jimmunol.174.6.3256
Autor:
Igor, Klyubin, Andrew J, Nicoll, Azadeh, Khalili-Shirazi, Michael, Farmer, Stephanie, Canning, Alexandra, Mably, Jacqueline, Linehan, Alexander, Brown, Madeleine, Wakeling, Sebastian, Brandner, Dominic M, Walsh, Michael J, Rowan, John, Collinge
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 34(18)
Alzheimer's disease (AD) is associated with pathological assembly states of amyloid-β protein (Aβ). Aβ-related synaptotoxicity can be blocked by anti-prion protein (PrP) antibodies, potentially allowing therapeutic targeting of this aspect of AD n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3f4f6e38e233bddd1bbc8c8fcb431be6
https://pubmed.ncbi.nlm.nih.gov/24790184
https://pubmed.ncbi.nlm.nih.gov/24790184
Autor:
Mark W. Lowdell, Anna K. Magnusson, Christian Landles, Azadeh Khalili-Shirazi, Thomas Möller, Michael R. Hayden, Mahmoud A. Pouladi, Edward J. Wild, Nayana Lahiri, Elsa Raibon, Richard V. Lee, Denis Soulet, Patrik Brundin, Ralph Andre, Caroline L. Benn, Maria Björkqvist, Sarah J. Tabrizi, Aurelio Silvestroni, Jenny Thiele, Gillian P. Bates, Ben Woodman, Blair R. Leavitt
Publikováno v:
The Journal of Experimental Medicine
Huntington's disease (HD) is an inherited neurodegenerative disorder characterized by both neurological and systemic abnormalities. We examined the peripheral immune system and found widespread evidence of innate immune activation detectable in plasm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b41b5f8985195323dfe3c53adadb6c62
https://pubmed.ncbi.nlm.nih.gov/18625748
https://pubmed.ncbi.nlm.nih.gov/18625748
Autor:
Azadeh Khalili-Shirazi, Patrik Brundin, Anna K. Magnusson, Aurelio Silvestroni, Sarah J. Tabrizi, Jenny Thiele, Mark W. Lowdell, Gillian P. Bates, Maria Björkqvist, Thomas Möller, Michael R. Hayden, Blair R. Leavitt, Ben Woodman, Denis Soulet, Ralph Andre, Christian Landles, Caroline L. Benn, Mahmoud A. Pouladi, Edward J. Wild
Publikováno v:
Alzheimer's & Dementia. 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e4b25b6aa77317b13c95ade50627b18
https://doi.org/10.1016/j.jalz.2008.05.1947
https://doi.org/10.1016/j.jalz.2008.05.1947