Výsledky vyhledávání - "Azadeh Hassanzadeh"

Akademický článek

Development of a semi-automated MHC-associated peptide proteomics (MAPPs) method using streptavidin bead-based immunoaffinity capture and nano LC-MS/MS to support immunogenicity risk assessment in drug development

Autor: M. Violet Lee, Ola M. Saad, Sylvia Wong, Jason LaMar, Lynn Kamen, Ben Ordonia, Rachel Melendez, Azadeh Hassanzadeh, Shan Chung, Surinder Kaur

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

Major histocompatibility complex (MHC)-Associated Peptide Proteomics (MAPPs) is an ex vivo method used to assess the immunogenicity risk of biotherapeutics. MAPPs can identify potential T-cell epitopes within the biotherapeutic molecule. Using adalim

Externí odkaz: https://doaj.org/article/0bd769f29dfe4b1888748f001e7e2a9e

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Introducing dendritic cell antibody internalization as an immunogenicity risk assessment tool

Autor: Rachel Melendez, Benjamin Ordonia, Joyce Guerrero, Azadeh Hassanzadeh, Peter Tran, Justin Low, Manda Wong, Jochen Brumm, Shan Chung, Lynn Kamen

Publikováno v: Bioanalysis. 14:703-713

Aim: Immunogenicity risk assessment assays are powerful tools that assess the relative immunogenicity of potential biotherapeutics. We detail here the development of a novel assay that measures the degree of antibody internalization by antigen-presen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76eb2863a5e037d8c5e86185a51608d9
https://doi.org/10.4155/bio-2022-0024

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Dendritic cells treated with exogenous indoleamine 2,3-dioxygenase maintain an immature phenotype and suppress antigen-specific T cell proliferation

Autor: Benjamin G. Keselowsky, Mark A. Wallet, Azadeh Hassanzadeh, Maigan A. Brusko, Evelyn Bracho-Sanchez

Publikováno v: J Immunol Regen Med

Indoleamine 2,3-dioxygenase (IDO), an intracellular enzyme responsible for catalyzing the rate limiting step of tryptophan catabolism, plays a critical role in immune cell suppression and tolerance. Indoleamine 2,3-dioxygenase-mediated depletion of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56d6487f80db592765a26da7cb7652ce
https://doi.org/10.1016/j.regen.2019.100015

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Influence of Tyrphostin AG490 on the expression of diabetes-associated markers in human adipocytes

Autor: Rhonda M. Cooper-DeHoff, Abdoreza Davoodi-Semiromi, Martin Wabitsch, Mark A. Atkinson, Azadeh Hassanzadeh, Clive Wasserfall

Publikováno v: Immunogenetics. 65:83-90

Tyrosine kinase inhibitors (TKi) hold promise as a treatment for a variety of disorders ranging from those in oncology to diseases thought as immune mediated. Tyrphostin AG490 is a potent Jak-Stat TKi shown effective in the prevention of allograft tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5164c8baeb2e5b2071b397e7d6abe88b
https://doi.org/10.1007/s00251-012-0659-4

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Tyrphostin AG490 Agent Modestly but Significantly Prevents Onset of Type 1 in NOD Mouse; Implication of Immunologic and Metabolic Effects of a Jak-Stat Pathway Inhibitor

Autor: Andrew Droney, Clive Wasserfall, Mark A. Atkinson, Azadeh Hassanzadeh, Abdoreza Davoodi-Semiromi

Publikováno v: Journal of Clinical Immunology. 32:1038-1047

Previously, we have reported that the Jak-Stat signaling pathway is defective in NOD mice. In this study, prediabetic female NOD mice (4 weeks) were treated by intraperitoneal injection either with AG490 or DMSO three times per week for 4 consecutive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef1c4beff00b459893c0e1ddf62f67fc
https://doi.org/10.1007/s10875-012-9707-y

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