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Akademický článek

De novo design of miniprotein antagonists of cytokine storm inducers

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)

Abstract Cytokine release syndrome (CRS), commonly known as cytokine storm, is an acute systemic inflammatory response that is a significant global health threat. Interleukin-6 (IL-6) and interleukin-1 (IL-1) are key pro-inflammatory cytokines involv

Externí odkaz: https://doaj.org/article/5f93a3f590e5444ea2f8d8872b6aedb3

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Akademický článek

Improving de novo protein binder design with deep learning

Autor: Nathaniel R. Bennett, Brian Coventry, Inna Goreshnik, Buwei Huang, Aza Allen, Dionne Vafeados, Ying Po Peng, Justas Dauparas, Minkyung Baek, Lance Stewart, Frank DiMaio, Steven De Munck, Savvas N. Savvides, David Baker

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-9 (2023)

Abstract Recently it has become possible to de novo design high affinity protein binding proteins from target structural information alone. There is, however, considerable room for improvement as the overall design success rate is low. Here, we explo

Externí odkaz: https://doaj.org/article/279adbbdbddf4e41bbd9f4a899f986cf

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Improving de novo Protein Binder Design with Deep Learning

Autor: Nathaniel Bennett, Brian Coventry, Inna Goreshnik, Buwei Huang, Aza Allen, Dionne Vafeados, Ying Po Peng, Justas Dauparas, Minkyung Baek, Lance Stewart, Frank DiMaio, Steven De Munck, Savvas N. Savvides, David Baker

We explore the improvement of energy-based protein binder design using deep learning. We find that using AlphaFold2 or RoseTTAFold to assess the probability that a designed sequence adopts the designed monomer structure, and the probability that this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::67ef1ed5128106ab6a3f74277fb56334
https://doi.org/10.1101/2022.06.15.495993

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