Výsledky vyhledávání - "Az Alddien Natfji"

Conjugation to PEG as a Strategy to Limit the Uptake of Drugs by the Placenta: Potential Applications for Drug Administration in Pregnancy

Autor: Gianfranco Pasut, Frances Beards, Francesca Greco, Abbie Dodd, Az Alddien Natfji, Antonella Grigoletto, Lewis Renshall, Lynda K. Harris, Helen M. I. Osborn, Angelos Evangelinos

Publikováno v: Molecular Pharmaceutics. 19:345-353

Here, we evaluated the feasibility of non-prodrug PEG-drug conjugates to decrease the accumulation of drugs within the placental tissues. The results showed that PEG was biocompatible with the human placenta with no alteration of the basal rate of pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2666a0c847581476cb6e3b341d4656e7
https://doi.org/10.1021/acs.molpharmaceut.1c00498

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Conjugation of haloperidol to PEG allows peripheral localisation of haloperidol and eliminates CNS extrapyramidal effects

Autor: Helen M. I. Osborn, Az Alddien Natfji, Vitaliy V. Khutoryanskiy, Dmitry O. Nikitin, Kimberly A. Watson, Rouslan I. Moustafine, I. I. Semina, Gary J. Stephens, Francesca Greco, Hong Lin

We have previously reported the synthesis of a poly(ethylene glycol)-haloperidol (PEG-haloperidol) conjugate that retained affinity for its target D2 receptor and was stable in simulated physiological conditions. We hypothesised that this polymer-dru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5a4821dc554e03e1428d3b1602017f8

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A 3D printed drug delivery implant formed from a dynamic supramolecular polyurethane formulation

Autor: Shaban A. Khaled, Clive J. Roberts, Ricky D. Wildman, M. I. Evangelista Barreiros, Elizabeth A. Clark, Wayne Hayes, Az Alddien Natfji, Lewis R. Hart, Sara Salimi, Francesca Greco, Y. Wu

© 2020 The Royal Society of Chemistry. Using a novel molecular design approach, we have prepared a thermo-responsive supramolecular polyurethane as a matrix material for use in drug eluting implants. The dynamic supramolecular polyurethane (SPU) is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::513c6a6eac724e0415baf9d69053ba8d

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Feasibility of polymer-drug conjugates for non-cancer applications

Autor: Helen M. I. Osborn, Francesca Greco, Az Alddien Natfji

Publikováno v: Current Opinion in Colloid & Interface Science. 31:51-66

Polymer-drug conjugates have been intensely studied in the context of improving cancer chemotherapy and yet the only polymer-drug conjugate on the market (Movantik®) has a different therapeutic application (relieving opioid-induced constipation). In

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edb778ab5c486f1929c1efb2b077672d
https://doi.org/10.1016/j.cocis.2017.07.004

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Parameters affecting the enhanced permeability and retention effect: the need for patient selection

Autor: Divyashree Ravishankar, Az Alddien Natfji, Francesca Greco, Helen M. I. Osborn

The enhanced permeability and retention (EPR) effect constitutes the rationale by which nanotechnologies selectively target drugs to tumors. Despite promising pre-clinical and clinical results, these technologies have, in our view, underachieved comp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e21041b6652e5edd31e42751a02834b

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