Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Ayyappan K. Rajasekaran"'
Autor:
Ayyappan K. Rajasekaran, James M. Mullin, James M. Leatherman, Mansoor M. Ahmed, Anna E. Reeves, Jeffrey F. Harper, Susanne B. Nicholas, Charles Lassman, Anna Skay, Landon J. Inge, Cromwell E. Espineda, Daniel G. Wolle, Thu P. Huynh, Sigrid A. Rajasekaran
Epithelial-to-mesenchymal transition (EMT) is an important developmental process, participates in tissue repair, and occurs during pathologic processes of tumor invasiveness, metastasis, and tissue fibrosis. The molecular mechanisms leading to EMT ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39cbde3d69e62f7fe378d302e6466d92
https://doi.org/10.1158/1535-7163.c.6531620
https://doi.org/10.1158/1535-7163.c.6531620
Autor:
Ayyappan K. Rajasekaran, James M. Mullin, James M. Leatherman, Mansoor M. Ahmed, Anna E. Reeves, Jeffrey F. Harper, Susanne B. Nicholas, Charles Lassman, Anna Skay, Landon J. Inge, Cromwell E. Espineda, Daniel G. Wolle, Thu P. Huynh, Sigrid A. Rajasekaran
Supplementary Data from Na,K-ATPase Subunits as Markers for Epithelial-Mesenchymal Transition in Cancer and Fibrosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4174e6cb63ec9ca2d6f2d281a4faae66
https://doi.org/10.1158/1535-7163.22484855.v1
https://doi.org/10.1158/1535-7163.22484855.v1
Autor:
Justin M David, Ayyappan K Rajasekaran
Publikováno v:
Journal of Kidney Cancer and VHL, Vol 2, Iss 1, Pp 15-24 (2015)
Gramicidin A (GA) is a channel-forming ionophore that renders biological membranes permeable to specific cations which disrupts cellular ionic homeostasis. It is a well-known antibiotic, however it’s potential as a therapeutic agent for cancer has
Externí odkaz:
https://doaj.org/article/096d49ce252f4fa1bebe858a352c1264
Autor:
Thu P Huynh, Sonali P Barwe, Seung J Lee, Ryan McSpadden, Omar E Franco, Simon W Hayward, Robert Damoiseaux, Stephen S Grubbs, Nicholas J Petrelli, Ayyappan K Rajasekaran
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0122442 (2015)
Glucocorticoids are commonly used as palliative or chemotherapeutic clinical agents for treatment of a variety of cancers. Although steroid treatment is beneficial, the mechanisms by which steroids improve outcome in cancer patients are not well unde
Externí odkaz:
https://doaj.org/article/a8ce098a8e1c4231a254c1dbbadf5d65
Autor:
Valerie B Sampson, Justin M David, Isabel Puig, Pratima U Patil, Antonio García de Herreros, George V Thomas, Ayyappan K Rajasekaran
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e102041 (2014)
The Wilms' tumor transcription factor (WT1) was originally classified as a tumor suppressor, but it is now known to also be associated with cancer progression and poor prognosis in several malignancies. WT1 plays an essential role in orchestrating a
Externí odkaz:
https://doaj.org/article/8a27e95e53fb435b9cf8c27ece0ae5cb
Autor:
Xinqiao Jia, Samuel L. Scinto, David L. Burris, He Zhang, Aidan B. Zerdoum, A.C. Moore, Shuang Liu, Han Zhang, Ayyappan K. Rajasekaran, Liang Gong, Joseph M. Fox
Publikováno v:
Biomaterials. 180:24-35
Fibrous proteins found in the natural extracellular matrix (ECM) function as host substrates for migration and growth of endogenous cells during wound healing and tissue repair processes. Although various fibrous scaffolds have been developed to reca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d2c6b27551e782ee361e05a7c6d273d
https://doi.org/10.1016/j.biomaterials.2018.06.042
https://doi.org/10.1016/j.biomaterials.2018.06.042
Autor:
Kevin T. Dicker, Ying Hao, Joseph M. Fox, Ayyappan K. Rajasekaran, Aidan B. Zerdoum, Xinqiao Jia, Anitha Ravikrishnan, He Zhang, Eric W. Fowler, Jiyeon Song, Yi Li
Publikováno v:
ACS Applied Materials & Interfaces. 10:26016-26027
Chemical modification of engineered microenvironments surrounding living cells represents a means for directing cellular behaviors through cell-matrix interactions. Presented here is a temporally controlled method for modulating the properties of bio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f7e1569d3523088187200a6559e19e3
https://doi.org/10.1021/acsami.8b07632
https://doi.org/10.1021/acsami.8b07632
Publikováno v:
Biomacromolecules. 17:3750-3760
Toward the goal of establishing physiologically relevant in vitro tumor models, we synthesized and characterized a biomimetic hydrogel using thiolated hyaluronic acid (HA-SH) and an acrylated copolymer carrying multiple copies of cell adhesive peptid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab5adb036f36fe45aac838a254c74264
https://doi.org/10.1021/acs.biomac.6b01266
https://doi.org/10.1021/acs.biomac.6b01266
Autor:
Robert W. Mason, Xinqiao Jia, Vinu Krishnan, Adam E. Snook, Dakota J Kelly, Xian Xu, Ayyappan K. Rajasekaran, Scott A. Waldman
Publikováno v:
Molecular Pharmaceutics. 12:2101-2111
Nanomedicine has advanced to clinical trials for adult cancer therapy. However, the field is still in its infancy for treatment of childhood malignancies such as acute lymphoblastic leukemia (ALL). Nanotherapy offers multiple advantages over conventi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5af5baa9f71718372844cdd0735812b
https://doi.org/10.1021/acs.molpharmaceut.5b00071
https://doi.org/10.1021/acs.molpharmaceut.5b00071
Publikováno v:
Molecular Cancer Therapeutics. 12:2296-2307
Ionophores are lipid-soluble organic molecules that disrupt cellular transmembrane potential by rendering biologic membranes permeable to specific ions. They include mobile-carriers that complex with metal cations and channel-formers that insert into
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::817a3f4e5562b99a737ec5e11968f77e
https://doi.org/10.1158/1535-7163.mct-13-0445
https://doi.org/10.1158/1535-7163.mct-13-0445